Clinical trials: Stratification
Colorectal Cancer
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC
The current study will compare the blood expression level of lncRNA NNT-AS1 and hsa-miR-485-5p, as well as heat shock protein 90 (HSP90) serum levels in both healthy and CRC Egyptian patients' cohort peripheral blood samples.
- Trial name
- NCT06531902
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bladder Cancer, Bladder Cancer Recurrence
Multiplex Mutation Detection Using Mass Spectrometry in Bladder Cancer
Bladder cancer is a highly heterogeneous malignancy characterized by frequent genetic alterations that are closely associated with disease progression, recurrence risk, and treatment response.
- Conditions
- Bladder Cancer, Bladder Cancer Recurrence, Adjuvant Therapy for Bladder Cancer, Progression of Bladder Cancer
- Trial name
- NCT07424560
- Testing
- Multiplex Mutation Detection System for Bladder Cancer (Nucleic Acid Mass Spectrometry)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Zhilong Dong
Stroke, Cardiac Disease
Multifactorial Risk Stratification in Stroke Patients With Cardiac Disease
Prospective registry for multifactorial risk factor assessment, enrolling consecutive ischemic stroke/transient ischemic attack patients with structural, inflammatory, or arrhythmogenic cardiac disease, who are admitted to our…
- Trial name
- NCT04352790
- Volunteers
- 878 people
- Sponsor
- University Hospital Tuebingen
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Tuberculosis, Lower Resp Tract Infection
Triage UltraSound in Tb Endemic Regions
In Sub-Saharan Africa, lower respiratory tract infections (LRTIs) and tuberculosis (TB) jointly are the leading cause of overall mortality.
- Conditions
- Tuberculosis, Lower Resp Tract Infection, Pneumonia
- Trial name
- TrUST (NCT05423847)
- Testing
- POCUS
- Where
- 3 sites in Benin, Mali and 1 more
- Volunteers
- 504 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Prostate Cancer
Prolaris Enhanced Risk Stratification - an ecONomic and clinicAL Evaluation
One in 8 men will be diagnosed with prostate cancer during their lifetime. The majority of men diagnosed with prostate cancer have early stage disease, which can be managed in a variety of ways, ranging from monitoring to…
- Trial name
- PERSONAL (NCT03851211)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Hematuria
Study on Risk Assessment for Patients With Microscopic Hematuria (Non-Visible Blood in Urine) Using a Urine Marker Test
The goal of this clinical study is to learn how well a urine test called Xpert® Bladder Cancer Detect (Xpert BC-D) can help doctors assess the risk of bladder cancer in people with non-visible blood in their urine (microscopic…
- Trial name
- UroDetect III (NCT07307300)
- Where
- Germany
- Volunteers
- 1,475 people
- Sponsor
- Christian Bolenz
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
HEM-SURVIVE: Structuralized Follow-up for Childhood Hematological Malignancy Survivors
This study aims to construct a structuralized follow-up model for survivors of childhood hematological malignancies in China. Using a multicenter prospective cohort design, it will identify the burden and risk factors of late…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Lymphoma, Leukemia
- Trial name
- NCT07483749
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Chronic Obstructive Pulmonary Disease
Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease
Maximal consumption of oxygen (VO2max) during exercise is used in patients with chronic obstructive pulmonary disease (COPD) to stratify perioperative risk.
- Trial name
- NCT01294033
- Testing
- Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Myocardial Infarction (AMI)
Risk Stratification After Acute Myocardial Infarction With Cardiac MRI
Given the existing controversy regarding the appropriate determination time for placement of implantable cardioverter-defibrillator (ICD) in patients at risk for sudden cardiac death (SCD) following acute myocardial infarction…
- Trial name
- CR-2280 (NCT03725826)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Montefiore Medical Center
Non-ischemic Cardiomyopathy
Sudden Death Stratification
Sudden cardiac death (SCD) risk stratification is a challenge in non-ischemic cardiomyopathy (NICM). The underlying mechanism of monomorphic ventricular tachycardia (VT) is mostly scar related.
- Trial name
- NCT04607265
- Testing
- Cardiac MRI
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Skin Cancer
Stratification of Cutaneous Squamous Cell Carcinomas According to Its Transcriptomic, Metabolic and Inflammatory Characteristics
A collection of biological samples (skin) will be created to meet the objectives. Skin biopsies will be taken (excluding on face and fold), in accordance with standard practice.
- Trial name
- StratiKA (NCT06476964)
- Testing
- skin biopsies
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
Pulmonary Hypertension Due to Lung Diseases
Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients
Chronic lung diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension.
- Trial name
- NCT07498244
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Multiple Myeloma
Rationale for Cytogenetic Risk Stratification by Imaging Flow Cytometry in Multiple Myeloma
A pioneer study demonstrated a proof of concept for IS-FISH with the new ISX technology. This state of the art technology has been recently acquired by the CHU of Amiens.
- Trial name
- CIF-PM (NCT03983486)
- Testing
- Imaging flow cytometry in multiple myeloma
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bowel Preparation Before Colonoscopy
Improved Bowel Preparation Method for Colonoscopy Based on Different Risk Stratification
The purpose of this study is to evaluate the efficacy of polyethylene glycol（PEG） combined with lactulose for bowel preparation before colonoscopy in low-risk patients and high-risk patients.
- Trial name
- NCT04582942
- Testing
- PEG, PEG+lactulose
- Where
- China
- Volunteers
- 2,028 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Crohn Disease
Study of Factors and Mechanisms Influencing the Effects of Treatments in Crohn's Disease
The course of Crohn's disease (CD) varies considerably between patients, but reliable prognostic markers are not available in clinical practice.
- Trial name
- NCT04135027
- Testing
- no interventions
- Where
- 4 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heart Failure
RISK Stratification Using a Combination of Cardiac Troponin T and Brain Natriuretic Peptide in Patients Receiving CRT-D
The purpose of the study is to identify if the combined use of cardiac troponin enzyme (cTnT) and brain natriuretic peptide (BNP) can predict Heart Failure (HF)improvement and all-cause mortality in patients implanted with…
- Trial name
- RISK (NCT00453622)
- Testing
- Cardiac Resynchronization Therapy-Defibrillator
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Abbott Medical Devices
Emergencies, Heart Diseases
Evaluate the Predictive Impact of the MEESSI Score
Our primary purpose is to assess MEESSI score in predicting mortality and readmission of patients managed for acute heart failure (AHF) in Emergency Department.
- Trial name
- MEESSI (NCT05340972)
- Testing
- MEESSI score
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Cardiovascular Diseases
PLATELET TISSUE FACTOR AS BIOMARKER OF THROMBOTIC RISK IN CORONARY ARTERY DISEASE PATIENTS (TRIT-ONE)
Enhancing thrombotic risk stratification in patients with coronary artery disease (CAD) is crucial for the prevention and management of cardiovascular disease.
- Trial name
- TRIT-ONE (NCT06919731)
- Testing
- whole blood flow cytometry analisys
- Volunteers
- 600 people
- Sponsor
- Centro Cardiologico Monzino
Metastatic Colorectal Cancer
Evaluation of Trastuzumab in Combination With Lapatinib or Pertuzumab in Combination With Trastuzumab-Emtansine to Treat Patients With HER2-positive Metastatic Colorectal Cancer
This is a Phase II multi-center 2-sequential cohorts trial, designed to assess the objective response rate of two anti HER2 combination in advanced disease CRC patients harbouring an amplified HER2 tumor assessed according to…
- Trial name
- HERACLES (NCT03225937)
- Testing
- Trastuzumab, Lapatinib, Pertuzumab, trastuzumab-emtansine
- Where
- 7 sites in Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia