Clinical trials: Stratification
Barrett's Esophagus, Esophageal Adenocarcinoma
A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer
This study serves, in part, to prepare for a future large cohort study. The goal of the study is: 1. The collection of various tissue samples (blood, biopsies and "esophageal brushes") and their analysis. 2.
- Trial name
- Endeavor-1 (NCT06523374)
- Testing
- Endoscopic brush cytology
- Where
- 9 sites in Belgium, Denmark and 4 more
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Hepatecellular Carcinoma, Hepatectomy
AI-Based Prediction of HCC Recurrence Patterns After Resection (APAR)
This observational study aims to validate a deep learning model for predicting aggressive recurrence patterns in patients with early-stage liver cancer (HCC) after surgery.
- Trial name
- NCT07062380
- Testing
- Curative liver resection, Real-world multimodal therapy
- Where
- China
- Volunteers
- 353 people
- Sponsor
- Tongji Hospital
Chronic Obstructive Pulmonary Disease
Clinical And Social Characteristics and Demographics in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a condition resulting from environmentally induced lung damage e.g. cigarette smoking and air pollution which, over time, causes individuals to suffer from symptoms including…
- Trial name
- CASCADE (NCT02882165)
- Testing
- Medical review
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Southampton
Coronary Artery Disease
Plaque Stratification Using Ccta in Coronary ARtery Disease (PoSTCARD)
Develop time-to-event prediction and plaque phenotype classification models for patients with known or suspected coronary artery disease.
- Trial name
- PoSTCARD (NCT04439643)
- Testing
- vascuCAP
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Elucid Bioimaging Inc.
Coronary Artery Bypass
A Retrospective Analysis of the Predictive Potential of Pre-operative
Roughly thirty percent of people that undergo open heart surgery get an abnormal heart beat afterwards known as atrial fibrillation (AF).
- Trial name
- NCT00321282
- Testing
- Atrial Fibrillation
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Emory University
Endometrial Cancer
Immunotolerance in Endometrial Cancer and at the Maternal-fetal Interface: Immunological Profiling of the Tumor Microenvironment in Risk Stratification of Recurrence
This pilot/exploratory study will be configured as a non-retro-prospective study interventional on endometrial tissue samples taken from surgically treated patients at the Regina Elena National Cancer Institute, IRE - IFO and…
- Trial name
- NCT06250010
- Testing
- tissue samples (healthy and tumor taken from the same patient) and tissue samples (decidualized endometrium and trophoblast taken from it patient)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Regina Elena Cancer Institute
Oropharyngeal Squamous Cell Cancer
Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer
Investigators will determine whether a treatment paradigm of up-front neck dissection, to more accurately pathologically stage patients, minimizing the number of treatment modalities in patients with low risk oropharyngeal…
- Trial name
- NCT02784288
- Testing
- Neck Dissection, Standard-of-Care (SOC) Transoral Surgery of Primary Site, SOC Radiation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan Rogel Cancer Center
Chest Pain
Rapid Diagnosis of Patients With Chest Pain During the Covid-19 Outbreak (My-ABCDE)
During the outbreak of COVID-19, among patients with chest tightness and chest pain as the main symptoms in major medical institutions in Shanghai, China, the past medical history and rapid testing were used to quickly identify…
- Trial name
- My-ABCDE (NCT05394038)
- Testing
- None，observational study.
- Where
- China
- Volunteers
- 2,218 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Breast Cancer
Prospective Validation Trial of Circulating Tumor Cells (CTCs) in Women With Metastatic Breast Cancer
Primary Objectives: 1. To validate the prognostic significance of circulating tumor cells (CTCs) in patients with newly diagnosed metastatic breast cancer (MBC). 2.
- Trial name
- NCT00493350
- Testing
- Blood Sample
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- M.D. Anderson Cancer Center
Heart Failure, Cardiovascular Risk Factors
Determining Efficacy of an Artificial Intelligence-based System for Heart Failure Detection Through Interpretation of Electrocardiograms (DECISION)
The DECISION trial aims to evaluate the efficacy of an artificial intelligence (AI)-powered system, Willem™, for improving the detection of heart failure (HF) in primary care settings by interpreting electrocardiograms (ECGs).
- Trial name
- DECISION (NCT07113223)
- Testing
- Willem™ platform ECG assessment
- Where
- 5 sites in Spain, Sweden
- Volunteers
- 1,968 people
- Sponsor
- Idoven 1903 S.L.
Pulmonary Embolism
Risk Stratification for Patients Presenting With Acute Pulmonary Embolism (PE)
Hypothesis: Increases in CRP, trop T, and BNP values will correlate significantly with right heart failure on echocardiogram and with mortality, ICU stay, hospital stay, and escalations in care. 1.
- Trial name
- NCT00562042
- Volunteers
- 28 people
- Sponsor
- Walter Reed Army Medical Center
Lung Diseases, Obstructive, Postoperative Complications
Preoperative Self-assessment for Cardio-pulmonary Risk Stratification
This prospective study intends to development and validation a patient self-assessment questionnaire. The aim of the self-assessment, by questionnaire, is to estimate the risk of postoperative pulmonary complications (PPC).
- Conditions
- Lung Diseases, Obstructive, Postoperative Complications, Cardiac Event
- Trial name
- PRESELECT (NCT04156594)
- Where
- Germany
- Volunteers
- 5,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertension, Cost Effectiveness
Cost-effectiveness of RAMP-HT for Patients With Uncontrolled Hypertension in Hong Kong
Hypertension (HT) is an important risk factor for stroke, coronary heart disease (CHD), heart failure and renal diseases, and the leading risk factor of global disease burden.
- Trial name
- NCT03301194
- Testing
- RAMP-HT
- Where
- Hong Kong
- Volunteers
- 158,322 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Papillary Thyroid Carcinoma, Recurrence Free Survival
Clinicopathological Predictors of Recurrence in Papillary Thyroid Carcinoma
The goal of this observational study is to identify demographic and clinicopathological factors associated with disease recurrence in adults with histologically confirmed papillary thyroid carcinoma (PTC) who achieved an initial…
- Trial name
- NCT07695974
- Where
- Italy
- Volunteers
- 1,113 people
- Sponsor
- University of Roma La Sapienza
Infection Viral, Infection, Hospital
Early Risk Stratification of Patient Hospitalized for SARS-CoV2 Infection: Critical COVID-19 France CCF
The COVID-19 pandemic of SARS CoV2 (Severe Acute Respiratory Syndrome, COVID-19) infection, which is currently evolving in France, raises many questions about the clinical and biological profile of infected hospitalized patients.
- Conditions
- Infection Viral, Infection, Hospital, COVID
- Trial name
- CCF (NCT04344327)
- Where
- 23 sites in France
- Volunteers
- 2,878 people
- Sponsor
- French Cardiology Society
Post-Concussion Syndrome
Post Concussion Symptoms Risk Stratification Tool
Patients with Persisting Concussion Symptoms (PCS) have a multitude of different symptoms. Some patients are at risk of prolonged symptoms but currently there is no tool to assist in identifying patients at high risk.
- Trial name
- NCT05664620
- Testing
- Risk Stratification Tool
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University Health Network, Toronto
Breast Neoplasms, Breast Reconstruction
DIEP-MDS for Risk Stratification of Flap Vascular Compromise and Failure in Breast Reconstruction
This multicenter retrospective observational study will develop and validate a CTA-based quantitative risk score-the DIEP Morphological Deviation Score (DIEP-MDS)-to estimate the risk of flap-related vascular compromise and flap…
- Conditions
- Breast Neoplasms, Breast Reconstruction, Postoperative Complications
- Trial name
- DIEP-MDS (NCT07761390)
- Where
- 20 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Zhuliling
Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis
Stratification and Treatment in Early Psychosis Study - PROMOTE
The purpose of this trial is: To investigate whether cannabidiol (CBD), compared to placebo, can reduce the severity of attenuated psychotic symptoms in individuals at clinical high risk for psychosis.
- Conditions
- Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis, Clinical High Risk for Developing Psychosis
- Trial name
- STEP-PROMOTE (NCT07434973)
- Testing
- Cannabidiol (CBD)
- Where
- 19 sites in Austria, Canada and 8 more
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Lung Neoplasms
Risk Stratification of Patients Using the Lung Cancer Biomarker Panel in China
The purpose of this study is to verify clinical utility of a simple blood test comprising of four protein- based markers for risk stratification of patients presenting symptoms related to lung cancer.
- Trial name
- LCBP (NCT01928836)
- Where
- 6 sites in China
- Volunteers
- 764 people
- Sponsor
- Bai Chunxue
Chronic Obstructive Pulmonary Disease, Asthma
Evaluation of ST2 and IL-33 in Patients Presenting to the Emergency Department With Trouble Breathing
Trouble breathing (dyspnea) is a nonspecific symptom associated with many diseases such as chronic obstructive pulmonary disease (lung disorder in which the flow of air to the lungs is blocked), asthma, pneumonia, pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Pulmonary Embolism, Pneumonia
- Trial name
- NCT00707811
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- The Cleveland Clinic