Clinical trials: Stratification
Pancreatic Ductal Adenocarcinoma (PDAC)
Metabolomic and Immune-Microbiome Profiling for Unresectable Pancreatic Cancer
Brief Summary The goal of this observational study is to identify biomarkers and develop a personalised treatment stratification model for patients with unresectable pancreatic ductal adenocarcinoma (PDAC) in Taiwan.
- Trial name
- NCT07036978
- Testing
- Collecting biospecimens
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Chang Gung Memorial Hospital
Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance
PERSEUS is an academic, investigator-initiated, multicenter observational registry of adults with acute pulmonary embolism (PE), promoted by Azienda Ospedaliero-Universitaria Careggi (Florence, Italy).
- Conditions
- Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension, Right Ventricular Dysfunction, Pulmonary Embolism (PE)
- Trial name
- PERSEUS (NCT07855679)
- Testing
- Routine clinical care (no study intervention)
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Lung Cancer - Non Small Cell
RaFIST: A Radiomics-Based Tool for Intratumoral Fibrosis Stratification in Non-Small Cell Lung Cancer
Patients with suspected Lung cancer who underwent contrast-enhanced CT and pathological examinations at Center 1 between January 2011 and January 2020 and Center 2 between September 2017 and Januray 2020 were eligible for…
- Trial name
- NCT06908005
- Testing
- CT radiomic analysis, Fibrosis assessment
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Jinling Hospital, China
Penicillin Allergy
Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting
Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic.
- Trial name
- NCT03702283
- Testing
- Penicillin Allergic Risk Stratification Best Practice Alert
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Surgical Site Infection (SSI), Central Nervous System Tumor
A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery
1. Study Background For patients undergoing brain or spinal tumor surgery, postoperative surgical wound infection (known as "surgical site infection," SSI) is a recognized risk.
- Trial name
- NCT07378683
- Testing
- ML-Based Enhanced Intervention Package for SSI Prevention, Standard Postoperative Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ming Yang
Aortic Stenosis
Assessment of Myocardial Tissue Damage in Aortic Stenosis
Aortic stenosis (AS) is the most common valve disease in the United States and most common indication for valve replacement surgery. Anatomical and hemodynamic severity of AS is insufficient for elucidating patients' prognosis.
- Trial name
- NCT02101619
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Mayo Clinic
Elective Valvular Cardiac Surgery
Plasma Biomarkers in Cardiac Valve Surgery
The level of four biomarkers will be measured in the patients' plasma after induction of anaesthesia. There biomarkers are NT-ProBNP, ST2, Galectin-3 and GDF-15.
- Trial name
- NCT02641665
- Testing
- Cardiac valve surgery
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University of Liege
Non Ischemic Cardiomyopathy
Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in Heart Failure Patients Requiring Cardiac Resynchronisation Therapy
This randomized study aimed to compare the efficacy of LBBP without defibrillator vs biventricular pacing with defibrillator (BiV-ICD/CRT-D) in patients with LB-NICM and left ventricular ejection fraction (LVEF) ≤35% risk…
- Trial name
- MADURAI CRT (NCT07791407)
- Testing
- left bundle branch pacing, Biventricular pacing with defibrillator
- Where
- India
- Volunteers
- 114 people
- Sponsor
- Velammal Medical College Hospital and Research Institute
Non-severe Pulmonary Embolism, Pulmonary Embolism
Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study
The objective of the study is to evaluate the prognostic performance of the chair lift test in the initial assessment of the severity of non-severe pulmonary embolism in hospitalized patients, in comparison with the current…
- Conditions
- Non-severe Pulmonary Embolism, Pulmonary Embolism, Non-high-risk Pulmonary Embolism, Pulmonary Embolism Acute
- Trial name
- SIT-EP (NCT06166329)
- Testing
- chair lift test
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Rouen
Histologically Confirmed Metastatic or Locally Advanced Breast Cancer With no Radical Topical Treatment Available, If There is Liver Metastasis, Which the Researcher Believes Will be Difficult to Evaluate the Response Accurately With Bone Metastasis or CT
FDG PET-CT in Advanced Breast Cancer
This study is a prospective cohort study comparing metabolic response evaluation by F-18 FDG PET-CT versus conventional imaging for outcome stratification in patients with advanced breast cancer receiving first-line systemic…
- Trial name
- PET-000 (NCT07173868)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Hodgkin Lymphoma
HD16 for Early Stage Hodgkin Lymphoma
This study is designed to test the non-inferiority of the experimental arm compared to the standard arm in terms of Progression free survival (PFS).
- Trial name
- HD16 (NCT00736320)
- Testing
- ABVD (Adriamycin, Bleomycin, Vincristine, Dacarbazine), 20 Gy IFRT (Involved Field Radiotherapy)
- Where
- Germany
- Volunteers
- 1,150 people
- Sponsor
- University of Cologne
Type 2 Diabetes, Diabetes Related Complications
Time-In-Range Based Risk Stratification of Type 2 Diabetes Microvascular Complications
The goal of this observational study is to learn about the role of Time-in-Range to stratify the risk of micro vascular complications in adults with type 2 diabetes. The main questions it aims to answer are: 1.
- Conditions
- Type 2 Diabetes, Diabetes Related Complications, Diabetes; Retinopathy (Manifestation), Diabetes; Neuropathy, Polyneuropathy (Manifestation)
- Trial name
- TRACK2 (NCT05787990)
- Testing
- Diabetes Microvascular Complication Tests
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Singapore General Hospital
Opioid Use, Post Operative Pain
Assessment of the Development of Postoperative Persistent Postoperative Pain
During the postoperative period, it is possible to observe the development of acute pain, which lasts no longer than a week after surgery.
- Conditions
- Opioid Use, Post Operative Pain, Chronic Pain
- Trial name
- NCT05370924
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Endometrial Cancer
Advancing Risk Stratification in Endometrial Cancer
The DaPHNE study is an observational, ambispective, multicenter study designed to evaluate whether the integration of circulating tumor DNA (ctDNA) and plasma proteomic profiling with the 2023 FIGO staging system improves…
- Trial name
- DaPHNE (NCT07746024)
- Testing
- Liquid Biopsy
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Differentiated Thyroid Carcinoma, Papillary Thyroid Carcinoma
Bethesda Classification and Risk Stratification in Differentiated Thyroid Carcinoma
This observational study aims to evaluate the relationship between preoperative Bethesda classification of fine-needle aspiration cytology and postoperative American Thyroid Association (ATA) risk stratification in patients with…
- Conditions
- Differentiated Thyroid Carcinoma, Papillary Thyroid Carcinoma, Follicular Thyroid Carcinoma
- Trial name
- NCT07858097
- Volunteers
- 100 people
- Sponsor
- Assiut University
Indeterminate Pulmonary Nodules, Lung Metastases
AI & Radiomics for Stratification of Lung Nodules After Radically Treated Cancer
This study will assess the utility of radiomics and artificial intelligence approaches to new lung nodules in patients who have undergone radical treatment for a previous cancer.
- Conditions
- Indeterminate Pulmonary Nodules, Lung Metastases, Second Primary Cancer, Lung Cancer
- Trial name
- AI-SONAR (NCT05375591)
- Testing
- Non-Interventional Study
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Acute Myeloid Leukemia
Validation Study of a New Cytokine-based Dynamic Stratification Based on FLt3 Ligand Plasma Concentration Kinetic Profile and IL-6 Concentration During Induction of Acute Myeloid Leukemia
The investigators have recently demonstrated the strong impact in terms of survivals of Fms-like tyrosine kinase 3 ligand (FL) levels evaluated during intensive induction in acute myeloid leukemia (AML) patients.
- Trial name
- FLAMVAL (NCT04641910)
- Testing
- No intervention
- Where
- 25 sites in France
- Volunteers
- 201 people
- Sponsor
- Nantes University Hospital
Heart Failure
Risk Stratification Via HF-QRS and Fibrosis Biomarkers in Heart Failure
This study aims to evaluate whether high-frequency QRS (HF-QRS) signal parameters and circulating myocardial fibrosis biomarkers (such as PIIINP, Galectin-3, and sST2) can improve risk stratification in patients with chronic…
- Trial name
- STRIVE (NCT06959186)
- Volunteers
- 1,500 people
- Sponsor
- The First Affiliated Hospital of Bengbu Medical University
Low Back Pain
Risk Stratification in Primary Care Combined With Stratified-specific Physical Therapy Care for Low Back Pain
This study aims to examine patient outcomes following risk stratification for low back pain in Family Medicine combined with either matched physical therapy (PT - i.e., stratified-specific PT) treatments or current treatment in…
- Trial name
- NCT03065894
- Testing
- Matched Physical Therapy Intervention, Current Care in Family Medicine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Vermont Medical Center