Clinical trials: Stratification
Angina (Stable), Chest Pain Atypical Syndrome
The Use of Artificial Intelligence-Enhanced Electrocardiograms in the Chest Pain Clinic to Risk Stratify Patients, Provide Rapid Reassurance and Enable a Low-Cost Clinical Pathway
Our current pathway for investigating patients with chest pain differs depending on if the pain is cardiac sounding or not. National guidelines advise us that patients with non-cardiac chest pain do not need further tests beyond…
- Trial name
- NCT07757425
- Testing
- AI-ECG
- Where
- 2 sites in United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- Jamil Mayet
Prostate Cancer, Gleason Score
Dual-tracer PET Radiomics for Prostate Cancer Stratification
This single-center retrospective study aims to develop an interpretable radiomics model based on dual-tracer PET/CT to preoperatively predict the postoperative pathological Gleason grade group in treatment-naïve prostate cancer…
- Conditions
- Prostate Cancer, Gleason Score, PET/CT, Radiomics
- Trial name
- NCT07655648
- Testing
- PET/CT with Gallium-68 labeled PSMA and RM26
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Atherosclerosis, Cardiovascular Diseases
Carotid Intraplaque Neovascularization Combined With Stress Echo
The root cause of heart attacks and strokes is atherosclerosis, the hardening and thickening of blood vessels due to the presence of "plaque" which is a build-up of fat and cholesterol in the walls of vessels.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- CIRCE (NCT05416385)
- Testing
- Carotid Contrast Enhanced Ultrasound
- Where
- 6 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- Dr. Amer Johri
Sepsis, Septic Shock
Multicenter Symphony IL-6 Monitoring Sepsis ICU Validation Study
The primary objective of this study is to validate a pre-defined IL-6 concentration cutoff that predicts 28-day mortality in patients who are admitted or are intended to be admitted to the ICU diagnosed with sepsis or septic…
- Trial name
- SYMON II (NCT06654895)
- Where
- 5 sites in United States
- Volunteers
- 700 people
- Sponsor
- Bluejay Diagnostics, Inc.
Colorectal Cancer, Anaesthesia
Cardiopulmonary Exercise Testing and Preoperative Risk Stratification
The investigators would like to evaluate the use of cardiopulmonary exercise tests (CPX) in guiding the care pathway of patients undergoing colorectal operations.
- Conditions
- Colorectal Cancer, Anaesthesia, Critical Illness
- Trial name
- NCT00737828
- Testing
- Perioperative care pathway guided by CPX results
- Where
- 3 sites in United Kingdom
- Volunteers
- 228 people
- Sponsor
- University College London Hospitals
Myocarditis, Heart Failure
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
Magnetic properties of myocardial tissue change in the presence of disease. This is detectable in the change of rate of magnetic relaxation, and measurable by T1 and T2 mapping using cardiovascular magnetic resonance (CMR).
- Conditions
- Myocarditis, Heart Failure, Myocardial Fibrosis, Vascular Inflammation
- Trial name
- IMPReSSION (NCT04444128)
- Testing
- Cardiac Imaging
- Where
- Germany
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Pulmonary Disease
The Role of Endothelial Function Test in Risk Stratification for Early and Late Complications After Pulmonary Embolism
The aim of this study is to investigate the association between endothelial dysfunction, measured by RHI as assessed by the peripheral arterial tonometry method, and PE complications defined as re-event of PE or DVT, systemic…
- Trial name
- NCT03149471
- Testing
- Endothelial dysfunction test
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Prevention of Thromboembolic Events
Study to Assess the Safety, Tolerability, Effects on the Body, Absorption, Distribution and Elimination of 25 mg BAY2433334 in Renal Impairment Including Renal Replacement Therapy ("Dialysis")
BAY2433334 is under clinical development for prevention of complications in diseases such as heart attack, irregular heart beat or stroke which can arise by formation of blood clots elsewhere in the body and travels through the…
- Trial name
- NCT04510987
- Testing
- BAY2433334 single dose in treatment groups 1-4 and 6 as well as on the dialysis free day of treatment 5, BAY2433334 on dialysis treatment day
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Bayer
Breast Neoplasms, Artificial Intelligence (AI)
Non-Contrast Breast MRI Diagnosis and Risk Stratification Using DWI-Generated Synthetic Contrast Enhancement
This study is conducted under the ethics-approved project titled "Artificial Intelligence Solution for Simplifying the Diagnostic Workflow of Breast MRI''.The goal of this observational study is to develop an integrated breast…
- Conditions
- Breast Neoplasms, Artificial Intelligence (AI), Magnetic Resonance Imaging (MRI), Diffusion Magnetic Resonance Imaging
- Trial name
- NCT07598084
- Testing
- Non-contrast breast MRI diagnostic model
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Platelet Function Tests, Predictive Value of Tests
Risk Stratification Post TAVI Using TEG
Transcatheter aortic valve implantation (TAVI) has become the standard of care in elderly patients at increased risk for surgical aortic valve replacement . However, the optimal antithrombotic strategy post TAVI is still unclear.
- Conditions
- Platelet Function Tests, Predictive Value of Tests, Thrombelastography, Cardiovascular Diseases
- Trial name
- RISTRATAVI (NCT03649594)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Torben Pottgiesser
Pulmonary Embolism (Diagnosis), Venous Thromboembolism (VTE)
3D-EIT for Diagnosis and Monitoring of Pulmonary Embolism
This prospective observational study aims to validate three-dimensional electrical impedance tomography (3D-EIT) as a non-invasive bedside tool for the diagnosis and longitudinal monitoring of pulmonary embolism (PE).
- Trial name
- TIDE-PE (NCT07560293)
- Volunteers
- 115 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Local Cancer
Prognostic Relevance of Coagulation Activation in RIsk Assessment and Stratification
Carcinogenesis and coagulation activation are closely related processes. In a previous study of coagulation activation in stage I-IIA breast cancer patients, we developed a prognostic model that includes coagulation activation…
- Trial name
- ARIAS (NCT05806632)
- Testing
- Prognostic model
- Where
- 3 sites in Italy
- Volunteers
- 108 people
- Sponsor
- Regina Elena Cancer Institute
Acute Coronary Syndrome, Non-ST-Elevation Myocardial Infarction
Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)
The purpose of this project is to examine the effectiveness of computed tomographic angiography (CTA) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
- Conditions
- Acute Coronary Syndrome, Non-ST-Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT00449826
- Testing
- Computed Tomographic Angiography
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Covid19
Risk Stratification of Patients With Suspected COVID-19 Presenting to the ED
This project is an unfunded collaboration of approximately 30 emergency departments across Europe led by the EUSEM research network.
- Trial name
- EUROCOV (NCT04682093)
- Where
- 5 sites in Croatia, Finland and 3 more
- Volunteers
- 8,000 people
- Sponsor
- European Society for Emergency Medicine (EUSEM) Research Network
Chest Pain, Emergencies
RCT aiTriage Chest Pain Risk Stratification
Chest pain is one of the most common reasons people visit the Emergency Department (ED). While most cases are not serious, a small number may lead to life-threatening heart problems, known as Major Adverse Cardiac Events (MACE).
- Trial name
- NCT07074808
- Testing
- aiTriage risk score
- Where
- 2 sites in Singapore
- Volunteers
- 1,120 people
- Sponsor
- Singapore General Hospital
Rare Cancers, Multiomics
Molecularly Aided Stratification for Tumor Eradication Research
NCT/DKFZ/DKTK MASTER is a prospective, continuously recruiting, multicenter observational study for biology-guided stratification of adults with rare cancers, including rare subtypes of common entities, using comprehensive…
- Trial name
- NCT-MASTER (NCT05852522)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- German Cancer Research Center
Breast Cancer
Breast Cancer Liquid Biopsy Stratification
Breast cancer is the most common cancer in Austrian women. Estimation of prognosis and treatment strategies is increasingly being dependent on stratification of tumors into different entities or classes.
- Trial name
- BALIBISTRA (NCT03992521)
- Testing
- Nucleosome positioning
- Where
- Austria
- Volunteers
- 59 people
- Sponsor
- Medical University of Graz
Hepatocellular Carcinoma (HCC)
STRATHEP: AI-Driven Treatment Stratification for Advanced Hepatocellular Carcinoma
STRATHEP develops and validates a multimodal AI model to predict treatment response in advanced hepatocellular carcinoma. By integrating digital pathology and MRI radiomics, the project identifies patients likely to benefit from…
- Trial name
- STRATHEP (NCT07863258)
- Where
- 5 sites in Belgium
- Volunteers
- 280 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fatty Liver, NAFLD - Non-Alcoholic Fatty Liver Disease
Detecting Liver Fibrosis in Patients At-risk
The project will establish a research cohort (called STELIR; STEatotisk Liver-risk In Rogaland) based on a biobank with an associated health register.
- Conditions
- Fatty Liver, NAFLD - Non-Alcoholic Fatty Liver Disease, Nash, MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
- Trial name
- STELIR (NCT07775638)
- Testing
- Routine study procedure
- Where
- Norway
- Volunteers
- 1,200 people
- Sponsor
- Helse Stavanger HF
Aortic Stenosis
CMR-AI and Outcomes in AS
Background \& Aims: Artificial Intelligence (AI) in cardiac magnetic resonance (CMR) imaging has previously been shown to provide highly reproducible and accurate measures of myocardial structure and function, outperforming…
- Trial name
- NCT06128876
- Where
- 7 sites in Austria, Belgium and 4 more
- Volunteers
- 1,500 people
- Sponsor
- Medical University of Vienna