Clinical trials: Stratification
Acute Myeloid Leukemia
Validation Study of a New Cytokine-based Dynamic Stratification Based on FLt3 Ligand Plasma Concentration Kinetic Profile and IL-6 Concentration During Induction of Acute Myeloid Leukemia
The investigators have recently demonstrated the strong impact in terms of survivals of Fms-like tyrosine kinase 3 ligand (FL) levels evaluated during intensive induction in acute myeloid leukemia (AML) patients.
- Trial name
- FLAMVAL (NCT04641910)
- Testing
- No intervention
- Where
- 25 sites in France
- Volunteers
- 201 people
- Sponsor
- Nantes University Hospital
Lung Cancer
Efficacy Study of a Selective Chest Wall Restriction Belt in Postoperative of Lung Resection
The objective of this study is to evaluate the efficacy of a new medical device in post-surgery of lung resection. The principle of this new device is based on selective chest wall restriction.
- Trial name
- CTS-POP (NCT04369118)
- Testing
- Conventional follow-up, Conventional follow-up+chest wall restriction belt
- Where
- 3 sites in France
- Volunteers
- 94 people
- Sponsor
- University Hospital, Grenoble
Heart Failure
Prospective Study With AMI Patients Undergoing PCI
CardioSAVE is a prospective 12-month controlled longitudinal study for the validation of a novel predictive model and a diagnostic tool, for the risk stratification of AMI patients undergoing PCI, with a one year follow-up.
- Trial name
- CardioSAVE (NCT03038360)
- Where
- Germany
- Volunteers
- 620 people
- Sponsor
- Firalis SA
Prediabetes, Health Communication
Study EHR Risk Stratification Tools
This study evaluates whether adding machine learning-based risk information to electronic health record (EHR) lab result messages helps older adults better understand their risk of developing diabetes and influences their…
- Conditions
- Prediabetes, Health Communication, Patient Comprehension
- Trial name
- NCT06995378
- Testing
- Hemoglobin A1c Lab Result Communication Tool
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of California, Los Angeles
Coronary Artery Disease, Genetic Predisposition to Disease
Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal Women
The investigators propose to genotype males and females at age 40 years and older, who are asymptomatic and without known heart disease (N=2000).
- Trial name
- NCT05169840
- Testing
- Genetic Risk Score for Coronary Artery Disease
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Breast Cancer
Prospective Validation Trial of Circulating Tumor Cells (CTCs) in Women With Metastatic Breast Cancer
Primary Objectives: 1. To validate the prognostic significance of circulating tumor cells (CTCs) in patients with newly diagnosed metastatic breast cancer (MBC). 2.
- Trial name
- NCT00493350
- Testing
- Blood Sample
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- M.D. Anderson Cancer Center
Coronary Heart Disease, Anemia
The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors…
- Conditions
- Coronary Heart Disease, Anemia, Bronchial Asthma, Stroke
- Trial name
- STOPRISK (NCT03945968)
- Where
- 38 sites in Russia
- Volunteers
- 16,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Acute Respiratory Distress Syndrome
Quantitative Computed Tomography for Mortality Risk Stratification in ARDS
Acute respiratory distress syndrome remains a deadly disease with hospital mortality remaining between 40 to 50%. ARDS mortality risk factors have been identified from patient history, common clinical and biological variables in…
- Trial name
- CT4ARDS-2 (NCT06113276)
- Testing
- Low dose computed tomography to evaluate biomechanical parameters in the lung
- Where
- 4 sites in France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon
Foot Ulcer, Diabetic
Reliability of a Diabetic Foot Ulcer Risk Stratification and Referral Algorithm
The main objective of this research study is to validate the St Joseph's Health Care Harmonized Foot Ulcer Assessment and Stratification tool using inter-rater reliability technique to determine if the score would consistently be…
- Trial name
- NCT03370237
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Thoracic Aortic Aneurysm (TAA)
Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors.
The aim of this observational study is to define the behavioural and cardiovascular risk factor profiles of patients with genetic aortopathies.
- Trial name
- PROM-1 (NCT07391293)
- Testing
- Journey to diagnosis, Quality of life, functional health and well-being, Awareness and self-esteem, acceptance of the condition
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- IRCCS Policlinico S. Donato
Myopia
AI-Stratified Myopia Control for Children in Remote Areas
This cluster-randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of an artificial intelligence-based, risk-stratified, tiered intervention model for childhood myopia prevention and control in…
- Trial name
- NCT07825428
- Testing
- Routine Screening and Referral, AI-Guided Tiered Management
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
COVID-19
CoronaWatch - Early Detection of Cardiovascular Risks in COVID-19 Via SmartWatch
In December 2019, a new viral disease called COVID-19 emerged. It is caused by the new corona virus SARS-CoV-2. It was initially described in the chinese city of Wuhan.
- Trial name
- CoronaWatch (NCT04376853)
- Testing
- Apple Watch Series 5
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg
Transient Ischemic Attack (TIA)
Canadian TIA Score Versus ABCD2 Score in Risk Stratification of Transient Ischemic Attack (TIA)
This study aims to evaluate the superiority of a clinical score (Canadian TIA score) compared to the currently more widely used score in clinical practice (ABCD2 score) in stratifying the risk of stroke or carotid…
- Trial name
- NCT06718075
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Carotid Artery Stenosis
Stratification of Patient With Carotid Disease
Introduction: Taxinomisis trial is part of the Taxinomisis project. The concept of the Taxinomisis project is to stratify carotid artery disease relying on new modern data corresponding to contemporary patients based on…
- Trial name
- TAXINOMISIS (NCT03495830)
- Testing
- Carotid endarterectomy
- Where
- 4 sites in Germany, Netherlands and 2 more
- Volunteers
- 270 people
- Sponsor
- University of Belgrade
Heart Failure
A Trial to Learn How Safe Vericiguat (BAY1021189) is and the Way the Body Absorbs, Distributes and Gets Rid of Vericiguat in Participants With Kidney Disease and in Age-, Weight- and Gender-matched Healthy Participants
Vericiguat (BAY1021189) is under development to treat heart failure, a condition in in which the heart has trouble pumping blood through the body.
- Trial name
- NCT04722484
- Testing
- Vericiguat (BAY1021189)
- Where
- Germany
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Bayer
Copd Exacerbation Acute, Readmission
Identification of Patients Admitted With COPD Exacerbations and Predicting Readmission Risk Using Machine Learning
Patients with Chronic Obstructive Pulmonary Disease (COPD) who are admitted to hospital are at high risk of readmission. While therapies have improved and there are evidence-based guidelines to reduce readmissions, there are…
- Conditions
- Copd Exacerbation Acute, Readmission, Machine Learning, Natural Language Processing
- Trial name
- NCT04192175
- Where
- Canada
- Volunteers
- 65,000 people
- Sponsor
- University Health Network, Toronto
Cardiovascular Diseases
Precision Medicine Study on Cardiovascular Disease (PRECISE)
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model.
- Trial name
- PRECISE (NCT04434911)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Type 2 Diabetes, Coronary Heart Disease
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
PREMAP invites residents of the Eloisa region (South Savo, Finland) turning 45, 50, or 55 years of age in 2026 to undergo a blood-based NMR metabolomics risk assessment for five interlinked cardio-renal-metabolic conditions (type…
- Conditions
- Type 2 Diabetes, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Disease
- Trial name
- PREMAP (NCT07820800)
- Testing
- Digital health interventions
- Where
- Finland
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Early-Stage Breast Cancer, Neoadjuvant Therapy
COGNITION: Genomics-Guided Precision Oncology in Early High-Risk Breast Cancer
The COGNITION diagnostic platform elucidates the biomarker profile of neoadjuvant chemotherapy-resistant residual bulk tumors in high risk early breast cancer patients.
- Trial name
- COGNITION (NCT05906407)
- Testing
- Genomic Profiling / Sequencing
- Where
- 12 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German Cancer Research Center
Lung; Node, Adenocarcinoma of Lung
Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung Cancer
This study is an observational study of blood and tissue biomarkers. Investigators plan to evaluate the accuracy of lung cancer biomarkers found in the blood in determining if a lung nodule is cancer or benign.
- Trial name
- NCT05665504
- Testing
- DetermaRX
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute