Clinical trials: Stratification
Osteosarcoma
ABCB1/P-glycoprotein Expression Influence on Non-metastatic Osteosarcoma of the Extremities
Post-authorization, observational, multicenter and prospective study in patients between 2 and 30 years old diagnosed with non-metastatic high-grade osteosarcoma of the extremities.
- Trial name
- NCT04383288
- Where
- 17 sites in Spain
- Volunteers
- 115 people
- Sponsor
- Grupo Espanol de Investigacion en Sarcomas
Advanced Colorectal Cancer
Identification of New Patient Stratification Tools in MSS RAS mt mCRC
This is a translational, multicentre and multinational study. The aim of this study is to identify new patient stratification tools in microsatellite stable RAS mutant metastatic Colorectal Cancer
- Trial name
- COLOSSUS (NCT03699111)
- Where
- 10 sites in Germany, Ireland and 1 more
- Volunteers
- 29 people
- Sponsor
- Cancer Trials Ireland
Surgery, Cardiovascular
BNP Evaluation Before Surgery Study: an Observational Study of Natriuretic Peptide Levels Prior to Surgery.
A prospective, multi-centre, observational study of preoperative natriuretic peptide testing for patients undergoing non-cardiac surgery conducted over four weeks.
- Trial name
- EPIC-2 (NCT04114032)
- Where
- South Africa
- Volunteers
- 174 people
- Sponsor
- University of Cape Town
Covid19, Cardiovascular Risk Factor
Cardiovascular Risk Stratification in Covid-19
This retrospective double-cohort study seeks to: 1. Describe the cardiovascular manifestations and electrophysiological (EP) substrate in COVID-19 infection and their association with clinical outcomes; and 2.
- Trial name
- CaVaR-Co19 (NCT04555187)
- Where
- United States
- Volunteers
- 1,355 people
- Sponsor
- Oregon Health and Science University
Brugada Syndrome, Cardiac Arrest
Feasibility of Improving Risk Stratification in Brugada Syndrome
Feasibility of Improving Risk Stratification in Brugada Syndrome (BrS), retrospective cohort study To study the reproducibility and specificity of V-CoS for activation heterogeneities predisposing to VT/VF in a larger series of…
- Conditions
- Brugada Syndrome, Cardiac Arrest, Athletes Heart, Atrial Fibrillation
- Trial name
- FIRST-BrS (NCT03992677)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Vulvar Cancer
STRatIfication of Vulvar Squamous Cell Carcinoma by HPV and p53 Status to Guide Excision
Vulvar cancer affects the external genitalia of women. This type of cancer is uncommon, arising mostly in older women and has been neglected in research and clinical trials.
- Trial name
- STRIVE (NCT05576831)
- Testing
- Re-excision
- Where
- Canada
- Volunteers
- 249 people
- Sponsor
- British Columbia Cancer Agency
Early Warning Score, Risk Stratification
Individual Early Warning Score (I-EWS)
Early Warning Score (EWS) is a clinical scoring system used in hospitals in Denmark and internationally to systematically observe admitted patients using a standardised response algorithm.
- Trial name
- NCT03690128
- Testing
- I-EWS with incorporated clinical assessment (Trigger Tool), Standard EWS - Control (Trigger Tool)
- Where
- 8 sites in Denmark
- Volunteers
- 150,000 people
- Sponsor
- Herlev Hospital
Infection
NEWS2+Procalcitonin Association in Patients With Infection and Its Significance in Oncological Patients
This observational study aims to evaluate the prognostic significance of the combination of a clinical score (specifically, a score obtained through the measurement of multiple parameters such as blood pressure, body temperature…
- Trial name
- NCT06761118
- Where
- Italy
- Volunteers
- 1,041 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Cancer
Prospective Validation Trial of Circulating Tumor Cells (CTCs) in Women With Metastatic Breast Cancer
Primary Objectives: 1. To validate the prognostic significance of circulating tumor cells (CTCs) in patients with newly diagnosed metastatic breast cancer (MBC). 2.
- Trial name
- NCT00493350
- Testing
- Blood Sample
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Pulmonary Embolism
HOME-PE2 : Home Treatment Versus Hospitalization in Patients With Acute Pulmonary Embolism, no Clinical Severity Criteria, and Either Right Ventricular Dysfunction or Elevated Troponin: a Randomized Controlled Trial
This study (HOME-PE2) is a multicenter, randomized controlled trial comparing home treatment versus hospitalization in patients with acute pulmonary embolism (PE) who have no clinical severity criteria according to the Hestia…
- Trial name
- HOME-PE2 (NCT07506291)
- Testing
- Home treatment, Hospitalization
- Where
- 18 sites in France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Angers
Pancreatic Ductal Adenocarcinoma (PDAC)
Metabolomic and Immune-Microbiome Profiling for Unresectable Pancreatic Cancer
Brief Summary The goal of this observational study is to identify biomarkers and develop a personalised treatment stratification model for patients with unresectable pancreatic ductal adenocarcinoma (PDAC) in Taiwan.
- Trial name
- NCT07036978
- Testing
- Collecting biospecimens
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Chang Gung Memorial Hospital
Heart Failure
Prospective Study With AMI Patients Undergoing PCI
CardioSAVE is a prospective 12-month controlled longitudinal study for the validation of a novel predictive model and a diagnostic tool, for the risk stratification of AMI patients undergoing PCI, with a one year follow-up.
- Trial name
- CardioSAVE (NCT03038360)
- Where
- Germany
- Volunteers
- 620 people
- Sponsor
- Firalis SA
Primary Prevention of Cardiovascular Disease
Polygenic Risk Score for Optimizing Primary Prevention in Intermediate-Risk Populations
The goal of this clinical trial is to determine whether incorporating a polygenic risk score (PRS) can optimize primary cardiovascular disease prevention in individuals with intermediate cardiovascular risk.
- Trial name
- PERSONAL (NCT07039123)
- Testing
- Polygenic Risk Score for Coronary Artery Disease (PRS-CAD), Standardized Risk Communication Tool (SCORE2)
- Where
- 2 sites in Switzerland
- Volunteers
- 205 people
- Sponsor
- University of Bern
Breast Cancer
Tumor Integrating Gut Microbiota in bREast Cancer
Study on patients undergoing surgery for breast cancer. Objective: to characterize the intratumoral microbiota and integrate these findings with clinicopathologic data, the estrobolome, and gut microbiota, with analyses…
- Trial name
- TIGER-BC (NCT07253168)
- Testing
- Surgery for breast cancer
- Volunteers
- 240 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pancreatic Ductal Adenocarcinoma
A Screening Program to Improve the Early Detection of Sporadic Pancreatic Cancer in Individuals With a High-Risk of Developing Pancreatic Cancer
This clinical trial studies a new screening program to improve the early detection of sporadic pancreatic cancer in individuals with a high risk of developing pancreatic cancer.
- Trial name
- AI-PACED (NCT07324096)
- Testing
- Biospecimen Collection, Computed Tomography with Contrast, Electronic Health Record Review
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Depression
The ISLAND Study: InSuLa Assessed Needs for Depression
While there are many effective options for treating a major depressive episode, there are no clinical markers that predict the likelihood of remission with an initial trial of either an antidepressant medication or psychotherapy.
- Trial name
- ISLAND (NCT02137369)
- Testing
- Selective serotonin re-uptake inhibitor, Cognitive Behavioral Therapy, Combination treatment (SSRI + CBT)
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Emory University
Acute Myeloid Leukemia
This Study Aims to Improve the Stratification of Patients With Acute Myeloid Leukemia to Enable More Personalized and Effective Treatments, and to Identify and Functionally Validate, at the Single-cell Level, Biomarkers That Can Predict Response to Venetoclax.
The current classification of acute myeloid leukemias (AML) includes more than 20 different diseases, grouped based on their distinctive genomic characteristics, which reflect substantial heterogeneity.
- Trial name
- AMANITA (NCT07874100)
- Testing
- Bulk genotyping of AML samples at diagnosis and relapse, scRNA analysis at diagnosis, scRNAseq and genotyping analysis at day 28 after therapy, spatial transcriptomic analysis at day 0 and 28
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Non ST Segment Elevation Acute Coronary Syndrome
Differential Diagnosis and Risk Stratification in Patients With Suspected NSTEACS
To evaluate possibilities of rapid differential diagnosis and risk stratification in patients urgently admitted to the CCU with a suspected acute coronary syndrome without persistent ST-segment elevation (NSTEACS).
- Trial name
- NCT04400500
- Testing
- Approaches to differential diagnosis and risk stratification
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- National Research Center for Preventive Medicine
Syncope
Improving Syncope Risk Stratification in Older Adults
Syncope (temporary loss of consciousness) is a frequent reason for an emergency department (ED) visit among older adults. The current ED evaluation of syncope frequently leads to hospitalization, results in low diagnostic yield…
- Trial name
- SRS (NCT01802398)
- Where
- 10 sites in United States
- Volunteers
- 3,707 people
- Sponsor
- University of Pennsylvania
Acute Myocardial Infarction
Right Ventricular Damage in Cardiovascular Magnetic Resonance
The purpose of this study is to determine the predictors of right ventricular damage (RVD) assessed by wall motion abnormalities, edema, myocardial salvage and delayed enhancement (DE)cardiac magnetic resonance imaging in acute…
- Trial name
- NCT01359306
- Volunteers
- 524 people
- Sponsor
- University of Leipzig