Clinical trials: Stratification
Coronary Artery Disease, Myocardial Infarction
Myocardial Infarction Genes (MI-GENES) Study
This study is being done to better understand how genetic information might improve assessment of heart attack risk.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Genomic Risk Communication
- Trial name
- MI-GENES (NCT01936675)
- Testing
- Genetic Risk Score
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colorectal Cancer, Stage III Colon Cancer
Prognostic Value of the Immunoscore® Colon Test for Disease Free Survival Stratification in Stage III Patients Under Oxaliplatin Treatment
The primary objective is to validate that the Immunoscore® test (IS0 to IS4) is able to identify patients with high risk (IS 0-1) of relapse or death whichever occurs first among Stage III patients under oxaliplatin-based…
- Trial name
- NCT03422601
- Testing
- Immunoscore test
- Where
- France
- Volunteers
- 1,122 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Thyroid Nodule
The Diagnostic Value of Shear Wave Elastography
Background: The main goal when diagnosing thyroid nodules, is to differentiate the few malignant from the overwhelming background of benign nodules.
- Trial name
- NCT02150772
- Testing
- Shear Wave Elastography (SWE)
- Where
- Denmark
- Volunteers
- 308 people
- Sponsor
- University of Aarhus
Pulmonary Arterial Hypertension (PAH), Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Incorporating the Venous Excess Ultrasound Score (VExUS Score) Into Contemporary Haemodynamic Risk Assessment in Pulmonary Arterial Hypertension: The INVEXUS-PAH Study
This prospective observational study aims to evaluate the relationship between the Venous Excess Ultrasound Score (VEXUS) and the ESC/ERS 2022 simplified four-strata risk assessment model in adult patients with World Health…
- Trial name
- INVEXUS-PAH (NCT07266012)
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Istanbul University - Cerrahpasa
Sepsis in ED Patients
REDS SCORE VERSUS qSOFA SCORE to Predict Mortality in Patients With Suspected Sepsis
Our goal in this work is to compare the predictive accuracy of the REDS score versus qSOFA in identifying in-hospital mortality among ED patients with suspected sepsis and improving outcomes in ED patients.
- Trial name
- NCT07271329
- Testing
- Sphygmomanometer
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Sudden Cardiac Death
Prospective Study to Identify Patients at Risk of Dangerous Ventricular Arrhythmias
The purpose of this study is to determine how well the device predicts susceptability to potentially lethal ventricular arrhythmias.
- Trial name
- HIP (NCT00562757)
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 320 people
- Sponsor
- Harbinger Medical, Inc.
Cervix Cancer, HPV Testing
Screening Triage and Risk Stratification
To investigate the performance of cytology, extended genotyping, p16/Ki67 dual stain cytology, DNA methylation and viral load as triage markers in post-menopausal HPV-screen-positive women aged 50-64 years in the organized…
- Conditions
- Cervix Cancer, HPV Testing, Postmenopausal Women
- Trial name
- I-share (NCT05727228)
- Testing
- cytology, p16/ki67 dual stain cytology (DS), extended genotyping, DNA methylation, viral load,
- Where
- Denmark
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Heart Failure
RISK Stratification Using a Combination of Cardiac Troponin T and Brain Natriuretic Peptide in Patients Receiving CRT-D
The purpose of the study is to identify if the combined use of cardiac troponin enzyme (cTnT) and brain natriuretic peptide (BNP) can predict Heart Failure (HF)improvement and all-cause mortality in patients implanted with…
- Trial name
- RISK (NCT00453622)
- Testing
- Cardiac Resynchronization Therapy-Defibrillator
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Diastolic
Multimodality Imaging in the Screening, Diagnosis and Risk StratifictiON of HFpEF
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04603404
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Indeterminate Pulmonary Nodules, Lung Metastases
AI & Radiomics for Stratification of Lung Nodules After Radically Treated Cancer
This study will assess the utility of radiomics and artificial intelligence approaches to new lung nodules in patients who have undergone radical treatment for a previous cancer.
- Conditions
- Indeterminate Pulmonary Nodules, Lung Metastases, Second Primary Cancer, Lung Cancer
- Trial name
- AI-SONAR (NCT05375591)
- Testing
- Non-Interventional Study
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Cancer-associated Thrombosis
Development of a Risk Stratification Score for Recurrent Venous Thromboembolism and Treatment-related Clinically Relevant Bleeding in Patients With Cancer-associated Thrombosis
The objective of this study is to prospectively develop a risk assessment model (RAM) that accurately identifies anticoagulated cancer-associated thrombosis (CAT) patients at low- and high-risk of recurrent venous thromboembolism…
- Trial name
- CAN-CATCH (NCT06894576)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Ottawa Hospital Research Institute
Non-Alcoholic Fatty Liver Disease
FCI Effectiveness in NAFLD Stratification
The goal of this pilot study is exploring whether field-cycling imaging may be able to detect characteristics of liver disease in patients with different degree of non-alcoholic fatty liver disease (NAFLD) that could be important…
- Trial name
- FIELDS (NCT05827432)
- Testing
- Field-cycling imaging (FCI)
- Where
- United Kingdom
- Sponsor
- NHS Grampian
Punctate White Matter Lesions, Neurodevelopmental Outcomes
MRI-Based Neurodevelopmental Risk Stratification in Infants With White Matter Injury
The goal of this observational study is to develop and evaluate an MRI-based assessment system for predicting neurodevelopmental outcomes in infants with punctate white matter lesions (PWML).
- Conditions
- Punctate White Matter Lesions, Neurodevelopmental Outcomes, Preterm Infants
- Trial name
- NCT07860749
- Where
- 10 sites in China
- Volunteers
- 260 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coronary Artery Disease
Plaque Stratification Using Ccta in Coronary ARtery Disease (PoSTCARD)
Develop time-to-event prediction and plaque phenotype classification models for patients with known or suspected coronary artery disease.
- Trial name
- PoSTCARD (NCT04439643)
- Testing
- vascuCAP
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Elucid Bioimaging Inc.
Pulmonary Embolism
Genetic Markers of Patients With History of Pulmonary Embolism Post Total Joint Arthroplasty
This study seeks to uncover potential genetic determinants of pulmonary embolism (PE). Our translational goal is to ultimately identify certain genetic markers that will allow us to stratify patients in terms of their PE risk…
- Trial name
- NCT03275610
- Testing
- Blood sample
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California
Preventive Cardiology, Respiration Disorders
"ADEN Platform: Pilot Clinical Validation for Chronic Disease Risk Stratification in Colombia"
This protocol describes a 90-day prospective pilot study designed to validate the capacity of the ADEN clinical intelligence platform to stratify early chronic disease risk across six priority public health profiles in Colombia.
- Conditions
- Preventive Cardiology, Respiration Disorders, Oncologic Disease, Autoimmune
- Trial name
- VALIDATES (NCT07727915)
- Testing
- Molecular Target
- Where
- Colombia
- Volunteers
- 120 people
- Sponsor
- Unidad de Investigación Genética Molecular
Angina (Stable), Chest Pain Atypical Syndrome
The Use of Artificial Intelligence-Enhanced Electrocardiograms in the Chest Pain Clinic to Risk Stratify Patients, Provide Rapid Reassurance and Enable a Low-Cost Clinical Pathway
Our current pathway for investigating patients with chest pain differs depending on if the pain is cardiac sounding or not. National guidelines advise us that patients with non-cardiac chest pain do not need further tests beyond…
- Trial name
- NCT07757425
- Testing
- AI-ECG
- Where
- 2 sites in United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- Jamil Mayet
Pancreatectomy
Tomoelastography in Predicting Postoperative Pancreatic Fistula
Postoperative pancreatic fistula (POPF) is a prevalent and severe complication of pancreaticoenteric anastomosis; however, its accurate preoperative prediction is challenging.
- Trial name
- POPF (NCT07014800)
- Where
- China
- Volunteers
- 157 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Intrahepatic Cholangiocarcinoma (Icc)
Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.
Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking.
- Trial name
- EXOMIC (NCT07224737)
- Testing
- EXOMIC small RNA sequencing, EXOMIC assay (qRT-PCR validation)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer
Long-Term Prospective Registry in Prostate Cancer Patients From Diverse Urology Practice Settings Following Prolaris® Testing
This registry will evaluate treatment selection for patients with newly diagnosed, localized prostate cancer following Prolaris testing.
- Trial name
- NCT04404894
- Where
- 7 sites in United States
- Volunteers
- 500 people
- Sponsor
- Myriad Genetic Laboratories, Inc.