Clinical trials: Stratification
Atrial Fibrillation
Cohort Study for Atrial Fibrillation Risk Stratification
AFHRI is planned as a prospective, single-center cohort study in patients at high risk of AF.
- Trial name
- AFHRI (NCT05442970)
- Where
- Germany
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Mesenteric Ischemia
Promoting Early Diagnosis of Chronic Mesenteric Ischemia
CMI is an incapacitating disease and timely diagnosis remains problematic. Despite the substantial compensatory capacity of the mesenteric circulation CMI is relatively common, its incidence being comparable to other well-known…
- Trial name
- PROMISE (NCT05735002)
- Testing
- 13C-butyrate breath test
- Where
- 4 sites in Netherlands
- Volunteers
- 296 people
- Sponsor
- Erasmus Medical Center
Lung Neoplasm, Thoracic Surgical Procedures
Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients
This multicenter prospective clinical study focuses on elderly patients with lung cancer. The investigators will build a standardized clinical registry database, develop perioperative risk stratification and surgical…
- Conditions
- Lung Neoplasm, Thoracic Surgical Procedures, Perioperative Care, Postoperative Rehabilitation
- Trial name
- NCT07632664
- Testing
- Pulmonary Lobectomy plus Mediastinal Lymph Node Sampling, Pulmonary Segmentectomy plus Mediastinal Lymph Node Sampling, Pulmonary Wedge Resection plus Mediastinal Lymph Node Sampling
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Lung Cancer (Diagnosis)
Prospective Multicenter Cohort Study for the Development and Evaluation of Risk Stratification Tools for Lung Cancers and Their Postoperative Recurrences Using Multimodal Clinical, Radiological, Tissue and Longitudinal Biological Phenotyping Among People at Risk of Lung Cancer
Interventional study with minimal risks and constraints, involving annual assessment of the prevalence and incidence of lung cancer using low-dose contrast-free thoracic CT scans, immunological, inflammatory, metabolic, blood…
- Trial name
- LUCA-pi COHORT (NCT07042867)
- Testing
- biobanking, low dose scan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple Myeloma, Newly Diagnosed
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
This is a prospective, single-center, clinical study to evaluate the efficacy and safety of a fully immunotherapy-based strategy guided by MRD-driven dynamic risk stratification in transplant-ineligible patients with newly…
- Trial name
- CAREMM-008 (NCT07106736)
- Testing
- BCMA CAR-T, GPRC5D/CD3 BiTEs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Cardiovascular Diseases
Precision Medicine Study on Cardiovascular Disease (PRECISE)
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model.
- Trial name
- PRECISE (NCT04434911)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Fluid Volume Disorder
Risk Stratification and Goal-directed Volume Therapy
It is difficulte to evaluate risk patients and to find the ideal intraoperative volume management. It seems to be that ill patients benefit of a goal directed volume management.
- Trial name
- NCT01456702
- Testing
- risk stratification group
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Metastatic Prostate Cancer, Castration-resistant Prostate Cancer
Molecular Stratification Profiling Protocol in Metastatic Castration Resistant Prostate Cancer (mCRPC) - MAESTRO
This study is a prospective, observational, molecular stratification profiling study. Patients with mCRPC who have received at least one standard treatment for mCRPC will be approached to participate in MAESTRO.
- Trial name
- MAESTRO (NCT03934164)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Acute Disease, Emergencies
Implementation of the Individual Danish Emergency Process Triage
The purpose of the study is to implement and evaluate a novel triage algorithm for risk stratification of acutely admitted patients in the Emergency Department.
- Conditions
- Acute Disease, Emergencies, Clinical Syndrome
- Trial name
- I-DEPT (NCT04571021)
- Testing
- I-DEPT, DEPT
- Where
- 8 sites in Denmark
- Volunteers
- 250,000 people
- Sponsor
- Herlev Hospital
Pre-diabetes, Diabetes
Assessing Progression to Type-2 Diabetes (APT-2D): A Prospective Cohort Study Expanded From BRITE-SPOT (Bio-bank and Registry for StratIfication and Targeted intErventions in the Spectrum Of Type 2 Diabetes)
The Bio-bank and Registry for StratIfication and Targeted intErventions in the Spectrum Of Type 2 Diabetes (BRITE-SPOT) has been set up to prospectively collect clinical data and biologically relevant samples from individuals…
- Trial name
- APT-2D (NCT02838693)
- Testing
- Not applicable. This is an observational study.
- Where
- Singapore
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Medicine
Epidemiology of Cardiovascular Risk
Selection of People at Low Cardiovascular Risk: Development of an Inexpensive Pre-screening Algorithm Using Only Non-laboratory Measures. The SKIM Risk Study.
Early identification of individuals at high risk remains the cornerstone of primary cardiovascular prevention (CV). However, cardiovascular screening including people at low CV diseases (CVD) risk are too costly, time consuming…
- Trial name
- SKIM (NCT03962309)
- Testing
- Health self-assessment questionnaire
- Where
- 3 sites in Italy
- Volunteers
- 2,699 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Heart Failure, Heart Failure With Reduced Ejection Fraction
AI-ECG for Time-Resolved Prediction of HFrEF
This study aims to develop and validate a deep learning-based electrocardiogram (ECG) model for predicting the future risk of heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricular Dysfunction, Cardiac Remodeling
- Trial name
- NCT07519434
- Where
- China
- Volunteers
- 286,709 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Infarction
CCT for Comprehensive Risk Stratification Following STEMI
The CT-STEMI study aims to evaluate a comprehensive cardiac computed tomography (CCT) protocol for assessing the risk of heart failure (HF), life-threatening arrhythmias (LTA), and atherothrombotic events following ST-elevation…
- Trial name
- CT-STEMI (NCT06020209)
- Testing
- Cardiac Computed Tomography, Cardiac Magnetic Resonance
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Melanoma
Gene Expression Profiles and ctDNA for Risk Stratification in Patients With Melanoma
This study aims at assessing the role of MerlinTM and ctDNA in predicting the nodal status in patients with >pT3b melanoma, therefore candidate for adjuvant therapy regardless of sentinel lymph node status.
- Trial name
- CORRESPOND (NCT06566404)
- Volunteers
- 200 people
- Sponsor
- European Institute of Oncology
Implantable Loop Recorder
Bradycardia Risk Stratification With Loop Recorder After Syncope
Syncope is a common symptom that may be related to a conductive disorder. If no bradycardia is authenticated, it is often necessary to implant an implantable loop recorder.
- Trial name
- NCT04200014
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Multimodality RV Phenotyping for Risk Stratification and Short-Term Outcomes in Group 1 PAH
The MIRROR-PAH is a single-center, prospective, observational cohort study evaluating the incremental value of multimodality imaging-derived right ventricular characteristics for risk stratification in patients with Group 1…
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Right Ventricular Function
- Trial name
- MIRROR-PAH (NCT07667673)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Liver Transplantation, Adjuvant FOLFOX Plus Lenvatinib
Stratification for F-L Therapy After LT
Objective: To stratify recipients who underwent adjuvant FOLFOX plus lenvatinib (F-L) therapy following liver transplantation (LT) for hepatocellular carcinoma and provide guidance for clinical adjuvant therapy.
- Conditions
- Liver Transplantation, Adjuvant FOLFOX Plus Lenvatinib, Machine Learning
- Trial name
- NCT06564103
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Xiao Xu
Oral Squamous Cell Carcinoma (OSCC)
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
This observational study will evaluate whether salivary interleukin-6 levels and selected interleukin gene polymorphisms are associated with regional lymph node involvement in patients with oral squamous cell carcinoma.
- Trial name
- IL6-OSCC (NCT07692360)
- Testing
- Saliva Collection and Biomarker Analysis
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- University of Pavia
Postoperative Complications
Derivation and Validation of the Extended Care (Ex-Care) Model II
The goal of this study is to develop a novel surgical risk stratification tool designed to adults operated in Brazil. The main question it aims to answer is: •Is the Extended Care (Ex-Care) II model a good tool to assess the risk…
- Trial name
- Ex-CareII (NCT05796024)
- Where
- Brazil
- Volunteers
- 107,372 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Endometrial Cancer
Advancing Risk Stratification in Endometrial Cancer
The DaPHNE study is an observational, ambispective, multicenter study designed to evaluate whether the integration of circulating tumor DNA (ctDNA) and plasma proteomic profiling with the 2023 FIGO staging system improves…
- Trial name
- DaPHNE (NCT07746024)
- Testing
- Liquid Biopsy
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS