Clinical trials: Stress
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Post Traumatic Stress Disorder
Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)
Posttraumatic stress disorder (PTSD) occurs in some people after exposure to events that cause extreme fear or helplessness. The incidence of war zones worldwide and the prevalence of violence in large cities in the U.S.…
- Trial name
- CSS (NCT01477762)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Emory University
Systemic Sclerosis, Pulmonary; Hypertension
Dimethyl Fumarate (DMF) in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
A double-blinded, placebo-controlled study of Dimethyl fumarate (DMF) in 34 Systemic Sclerosis-Pulmonary Hypertension (SSc-PAH) patients.
- Trial name
- NCT02981082
- Testing
- Dimethyl Fumarate (DMF)
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Robert Lafyatis
Myocardial Ischemia
The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
Ischemia reperfusion injury may be attenuated by HO-1 induction. Our previous data confirmed strong HO-1 induction in peripheral blood cells following heme arginate infusion in healthy humans.
- Trial name
- NCT02314780
- Testing
- Heme arginate 3mg/kg, Heme arginate 1mg/kg
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Martin Andreas, M.D.
Endothelial Dysfunction
Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function
Cigarette smoking is a significant risk factor for cardiovascular disease (CVD) and is the leading cause of premature mortality in the US.
- Trial name
- NCT01314443
- Testing
- Nicotine Replacement Therapy (NRT), Gamma-Tocopherol, Smoking cessation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Smoking Cessation
Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD)
The investigators propose to evaluate the relationship between PTSD, mood, craving and withdrawal symptoms and factors associated with relapse in the context of a randomized clinical smoking cessation trial.
- Trial name
- NCT01055886
- Testing
- nicotine patch
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimer Disease, Dementia
Efficacy of Caregiver Training Program in Enhancing Caregiver and Patient Outcomes
As part of Phase II of the NIH SBIR grant, the study will conduct a randomized controlled clinical trial in which the MapHabit system (MHS) will offer a caregiver training product in adjunct.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burden, Assistive Technology
- Trial name
- NCT05527405
- Testing
- The MapHabit System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- MapHabit, Inc.
PTSD
The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk
Some individuals who are exposed to traumatic events experience both psychological and cardiovascular changes that affect their health and well-being.
- Trial name
- ACCEPT (NCT02736929)
- Testing
- Cognitive Processing Therapy - Cognitive
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Duke University
Cutaneous Leishmaniasis
Efficacy and Safety of Miltefosine or Thermotherapy for Cutaneous Leishmaniasis in Colombia.
Cutaneous leishmaniasis (CL) is a worldwide disease, endemic in 88 countries, that has shown an increasing incidence the last two decades. It is estimated that in 2005, about of 20,000 new cases of CL were diagnosed in Colombia.
- Trial name
- NCT00471705
- Testing
- Miltefosine, Thermotherapy, Glucantime®
- Where
- Colombia
- Volunteers
- 437 people
- Sponsor
- Universidad de Antioquia
Substance Use Disorder, Post-traumatic Stress Disorder
Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD
Veterans with co-occurring Posttraumatic Stress Disorder and Substance Use Disorder (PTSD-SUD) experience more severe symptomatology and poorer response to existing treatments than Veterans with either disorder alone.
- Conditions
- Substance Use Disorder, Post-traumatic Stress Disorder, Moral Injury
- Trial name
- NCT03681288
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Opioid-use Disorder, Stress Related Disorder
Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment (R33 Phase)
This will be a randomized controlled trial (RCT) designed to compare live-online Mindful Recovery Opioid Care Continuum (M-ROCC) groups with a live-online control group on the primary outcome of number of biochemically confirmed…
- Conditions
- Opioid-use Disorder, Stress Related Disorder, Anxiety, Pain Interference
- Trial name
- Mindful-OBOT (NCT04278586)
- Testing
- Live-Online M-ROCC, Live-Online Control
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Cambridge Health Alliance
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Nightmares, Stress Disorders, Post-Traumatic
Understanding Trauma Nightmares Using In-Home Measurement
Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide.
- Conditions
- Nightmares, Stress Disorders, Post-Traumatic, Actigraphy, Respiratory Sinus Arrhythmia
- Trial name
- NCT03974503
- Testing
- Exposure, Relaxation, and Rescripting Therapy, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Depression, Postpartum, Anxiety Disorders
Inhaled Oxytocin and HPA Axis Reactivity
Mothers who were enrolled in the Mood, Mother and Infant study will be eligible to participate in the 6-year follow-up maternal visit.
- Conditions
- Depression, Postpartum, Anxiety Disorders, Stress, Psychological
- Trial name
- NCT03593473
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill
Cardiomyopathy, Dilated, Arrhythmia
Mental Stress Reduction in Defibrillator Patients
The purpose of this study is to assess the effectiveness of a 10 week program of Stress Management versus control Patient Education sessions on cardiac responses to mental stress in veterans with Implantable…
- Conditions
- Cardiomyopathy, Dilated, Arrhythmia, Anger, Stress
- Trial name
- NCT00624520
- Testing
- Cognitive Behavioral Stress Management (CBSM), Patient Education
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- US Department of Veterans Affairs
Nicotine Dependence
The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking
The purpose of the overall parent study is to determine the impact of gender and hormones (estradiol, progesterone, testosterone and cortisol) on responses to stress and smoking cues presented in daily, "real-world" cue…
- Trial name
- SCOR-III (NCT01576874)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Kevin Gray, MD
Burnout, Professional, Anxiety
Feasibility of a Yoga- and Mindfulness-Based Intervention for Resident Physicians
The investigators aim to initiate and complete the first investigation of the effect of a yoga-based program on resident physicians' psychological health using a randomized controlled trial to assess feasibility of the program in…
- Conditions
- Burnout, Professional, Anxiety, Depression, Stress
- Trial name
- NCT03687450
- Testing
- RISE yoga-based program
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
Stress Management for Patients With Multiple Sclerosis
There is a growing body of literature showing that stressful life events can increase the risk of developing exacerbations and new brain lesions among people with multiple sclerosis.
- Trial name
- NCT00147446
- Testing
- Individual Stress Management, Wait List Control
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- Northwestern University
Non PTSD, PTSD
Neurobiology of Sleep and Sleep Treatment Response in Returning Veterans
The overarching objectives of this study are: 1) To investigate the neurobiology of posttraumatic stress disorder (PTSD) during Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM) sleep relative to wakefulness; 2) To…
- Trial name
- NOSSTIP (NCT01637584)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depression Mild, Resilience, Psychological
The S.M.A.R.T. Project: Stress Management and Resilience Training for Teens
The rate of depression increases markedly over the course of adolescence. Adolescents struggling with depression are often set on a maladaptive behavior trajectory which may lead to academic challenges, substance abuse, risky…
- Conditions
- Depression Mild, Resilience, Psychological, Adolescent Behavior
- Trial name
- NCT03270943
- Testing
- MFY, HLG
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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