Clinical trials: Stress Biomarkers
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Autism Spectrum Disorder, Depression - Major Depressive Disorder
Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models
This study investigates whether AI-driven analysis of speech can accurately predict clinical diagnoses and assess risk for various mental or behavioral health conditions, including attention-deficit/hyperactivity disorder (ADHD)…
- Conditions
- Autism Spectrum Disorder, Depression - Major Depressive Disorder, Anxiety, Generalized, Bipolar Disorder (BD)
- Trial name
- MINDAIM (NCT06792175)
- Testing
- Solicue Machine Learning Models, Mercuria Machine Learning Models
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Psyrin Inc.
Mild Cognitive Impairment, Alzheimer Disease
Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment.
- Trial name
- Stress-AD (NCT05795634)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Johns Hopkins University
Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Acute
Intranasal Neuropeptide Y in Clinical Trial in Level Two Trauma Patients for PTSD and Acute Stress Disorder
Level 2 trauma patients admitted to Westchester Medical Center who consent and meet the inclusion criteria will answer a questionnaire, be tested on Beck Anxiety Index, assessed for vital signs and provide blood and urine samples…
- Trial name
- NCT04071600
- Testing
- Neuropeptide Y
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- New York Medical College
Pulmonary Disease, Chronic Obstructive
Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)
More patients with chronic obstructive pulmonary disease (COPD) die from cardiovascular disease than direct pulmonary complications.
- Trial name
- NCT01398943
- Testing
- Tetrahydrobiopterin (BH4), Antioxidant Cocktail
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Augusta University
Healthy Volunteers, Age Group: 60-70
Effect of an Anti-ageing Supplement on Oxidative Stress
This pilot study serves to investigate whether ProManna intake leads to any changes in baseline levels for oxidative stress markers.
- Conditions
- Healthy Volunteers, Age Group: 60-70, Overweight
- Trial name
- PromAge (NCT03272867)
- Testing
- ProManna
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Post Traumatic Stress Disorder
Effect of TMS on PTSD Biomarkers
The study will (1) assess feasibility of a TMS treatment in an underserved population; (2) determine if this TMS treatment protocol improves PTSD symptoms and biological markers of PTSD such as brain functioning and startle…
- Trial name
- NCT04563078
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Reference Values of BNP in Healthy Newborn
Normal Values of Brain Natriuretic Peptide in Healthy Newborn
Brain natriuretic peptide (BNP) is an important tool for diagnosis, risk stratification and prognosis in pediatric patients with heart failure1.
- Trial name
- NCT02574806
- Testing
- Blood sample and BNP measurement
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud
Effect of Selenium on Oxidative Stress in Healthy Men
Influence of Selenium on Prostate Cancer Related Biomarkers
Penn State Milton S. Hershey Medical Center researchers are trying to compare the effects of two different forms of selenium (selenium yeast and selenomethionine) on blood selenium levels and biomarkers of oxidative stress as…
- Trial name
- NCT01112449
- Testing
- selenomethionine, low dose selenized-yeast, high dose selenized-yeast
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Obstructive Sleep Apnea
Weight Loss and Obstructive Sleep Apnea
The purpose of this study is to evaluate the effects of moderate energy restriction on the body adiposity, severity of OSA, blood pressure, sympathetic activity, oxidative stress, inflammatory biomarkers, metabolic profile and…
- Trial name
- NCT02206126
- Testing
- Energy Restriction
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Diabetes Mellitus, Type 2
The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination
A. Four groups of patients with type 2 diabetes mellitus with high or very high cardiovascular risk or heart failure with preserved ejection fraction (HFpEF) will be studied before and at 6 and 12 months of treatment: 60 patients…
- Trial name
- NCT03878706
- Where
- Greece
- Volunteers
- 240 people
- Sponsor
- University of Athens
Healthy, Diabetes Mellitus Type 1
The Effect of Light Therapy on Cellular Energy and Oxidative Stress in Healthy Adults and Type 1 Diabetic Patients
The goal of this clinical trial is to evaluate the effects of low-level light therapy on cellular energy and oxidative stress in healthy adults and patients with Type 1 diabetes.
- Trial name
- PBM-T1D (NCT07833865)
- Testing
- Red and Near-Infrared Light Therapy Pad
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thi-Qar
Stress
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient way to evaluate the biological impact of day-to-day stressors that people encounter as they go about their lives, since saliva is so easy…
- Trial name
- NCT01673087
- Testing
- Metyrapone, Dexamethasone, Cortrosyn
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Ovarian Cancer, Fallopian Tube Adenocarcinoma
The Effects of Exercise on Distress, Quality of Life, and Biomarkers in Ovarian Cancer Survivors
Many individuals with ovarian cancer experience distress, fatigue, weakness, anxiety, and other symptoms that decrease quality of life.
- Conditions
- Ovarian Cancer, Fallopian Tube Adenocarcinoma, Fallopian Tube Carcinosarcoma, Fallopian Tube Clear Cell Adenocarcinoma
- Trial name
- NCT03641287
- Testing
- Exercise Counseling, Aerobic Exercise, Physiological Support
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Washington
Kidney Failure
Urinary Marker for Oxidative Stress in Human Cisplatin- Induced Renal Injury
We previously reported early measurement of urinary MDA might be a useful marker for the prediction of CDDP-induced renal damage in rat.
- Trial name
- NCT00310739
- Where
- Japan
- Sponsor
- Hamamatsu University
Cortisol Overproduction
Salivary Cortisol as Stress Marker in Newborns Subjected to Double Weighing With Physiological Body Weight
According to scientific revisions, salivary cortisol is a valid method for measuring adrenocortical activity in newborns because it is non-invasive in fact the measurement of salivary cortisol has been used as a stress marker in…
- Trial name
- NCT03830437
- Testing
- Evaluation of newborn stress, Evaluation of body weight trend
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Metabolic Syndrome
A Mediterranean Diet-Based Culinary Intervention in Adults With Metabolic Syndrome
Metabolic syndrome is a major public health concern associated with an increased risk of cardiovascular disease, type 2 diabetes, and premature mortality.
- Trial name
- CUINAMET (NCT07702695)
- Testing
- Mediterranean diet-based culinary intervention, Standard nutritional counseling
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Burnout, Secondary Traumatic Stress
Burnout, Secondary Traumatic Stress and Inflammatory Biomarkers in ICU Healthcare Workers
Healthcare professionals working in intensive care units (ICUs) are frequently exposed to high levels of psychological stress due to critically ill patients, frequent encounters with death, complex clinical decision-making, and…
- Conditions
- Burnout, Secondary Traumatic Stress, Occupational Stress, Inflammation
- Trial name
- NCT07437443
- Testing
- Psychometric Assessment and Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Hemodialysis Patients, Peripheral Vascular Disease
Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease
Peripheral arterial disease (PAD) is the most common manifestation of systemic atherosclerosis and accounts for significant morbidity and mortality among end-stage renal disease (ESRD) patients.
- Trial name
- NCT00431249
- Testing
- Cilostazol
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Smoking, Smoking Cessation
Biopsychosocial Predictors of Nicotine Relapse
This study aims to investigate the associations between emotion regulation ability, stress-induced neural activity changes, and susceptibility to relapse in smokers attempting to quit.
- Conditions
- Smoking, Smoking Cessation, Nicotine Addiction, Tobacco Smoking Behavior
- Trial name
- BioNic (NCT06470321)
- Testing
- Flexiquit Computerized Smoking Cessation Program
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus