Clinical trials: Stress Disorder
Asthma
Family-Focused, Stress-Reduction Program to Improve the Health Care of Urban Children With Asthma
Stress and anxiety can negatively affect children with asthma. Reducing the stress of asthmatic children and their families may lead to improved asthma care and fewer asthma symptoms in the children.
- Trial name
- ASPIRE (NCT00384813)
- Testing
- Project ASPIRE Home-Based Family Intervention, Project ASPIRE Enhanced Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Emory University
Coronary Artery Disease (CAD)
A Study of Regadenoson in Subjects Undergoing Stress Myocardial Perfusion Imaging (MPI) Using Multidetector Computed Tomography (MDCT) Compared to Single Photon Emission Computed Tomography (SPECT)
The purpose of this study is to compare Multidetector Computed Tomography (MDCT) and Single Photon Emission Computed Tomography (SPECT) stress myocardial perfusion imaging (MPI) with regadenoson in order to detect the presence or…
- Trial name
- NCT01334918
- Testing
- regadenoson, technetium Tc99m sestamibi /technetium Tc99m tetrafosmin, Contrast
- Where
- 11 sites in United States
- Volunteers
- 124 people
- Sponsor
- Astellas Pharma Inc
PTSD
A Comparison of Cognitive Processing Therapy (CPT) Versus Present Centered Therapy (PCT) for Veterans
The purpose of this study is to compare the effectiveness of Cognitive Processing Therapy (CPT) versus Present Centered Therapy (PCT) for male OEF/OIF Veterans with combat related PTSD.
- Trial name
- NCT00607815
- Testing
- Cognitive Processing Therapy, Present Centered Therapy
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-traumatic
Information Processing Modification in PTSD (Oct. 18)
The purpose of this study is to determine whether a computerized intervention designed to change the nature of attention biases will be effective in reducing the symptoms of post traumatic stress disorder (PTSD) in American…
- Trial name
- NCT00601952
- Testing
- Attention Bias Modification (ABM), Attention Control Condition (ACC)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- San Diego State University
Depressive Symptoms, Substance-related Disorders
Intervention for Veterans With Depression, Substance Disorder, and Trauma
This study will compare two different types of psychotherapy for Veterans with depression, addiction, and a past traumatic experience.
- Conditions
- Depressive Symptoms, Substance-related Disorders, Posttraumatic Stress Disorders
- Trial name
- NCT00958217
- Testing
- Cognitive Processing Therapy-Modified (CPT-M), Integrated Cognitive Behavioral Therapy (ICBT)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- VA Office of Research and Development
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Hyperglycemia, Cardiovascular Disease
Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction
The objective of this study is to formulate and validate a green tea confection (i.e. "gummy" candy) as a strategy to attenuate postprandial hyperglycemia-induced impairments in vascular function.
- Trial name
- NCT01857258
- Testing
- Green Tea Concentrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Heart Failure
Improving Self-care of Heart Failure Caregivers
Informal caregiving is demanding and stressful. Caregivers of adults with heart failure (HF) report significant stress and poor self-care.
- Trial name
- NCT03988621
- Testing
- ViCCY
- Where
- United States
- Volunteers
- 343 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Stress Hyperglycemia
Metabolic Phenotyping During Stress Hyperglycemia in Cardiac Surgery Patients
This study is a prospective randomized study to examine the effects of exposure to dulaglutide on the prevention of stress-hyperglycemia and the metabolic inflammatory response in the perioperative period.
- Trial name
- NCT03743025
- Testing
- Dulaglutide Injection, Saline Injection
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Emory University
Prematurity, Stress Reaction
Pilot Study of Nursing Touch and Biobehavioral Stress
Randomized cross-over clinical trial to determine the effect of a nurse-administered comforting touch intervention on the biobehavioral stress responses of preterm infants hospitalized in the neonatal intensive care unit.
- Trial name
- P-NAT-BIO (NCT05030233)
- Testing
- Nurse-Administered Touch Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University
Idiopathic Pulmonary Fibrosis
Rehabilitation of Idiopathic Pulmonary Fibrosis (IPF) Patients
The incidence and prevalence of IPF increase exponentially with age, and IPF occurs more often in older males. Cigarette smoking and environmental dust exposures are known risk factors for developing IPF.
- Trial name
- NCT01118221
- Testing
- pulmonary rehabilitation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- US Department of Veterans Affairs
PTSD, Physical Injury
IT Enhanced Peer Integrated Collaborative Care for US Trauma Care Systems
This study evaluates two readily implementable approaches to the delivery of transitional care for injured patients treated emergently in US trauma care systems.
- Trial name
- TSOS 7 Peer (NCT03569878)
- Testing
- Peer-Integrated Multidisciplinary Collaborative Care, Trauma surgery team notification
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Washington
Tobacco, Posttraumatic Stress Disorder
Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence
Veterans with PTSD have high rates of smoking (34%-86% vs. 18% in the general population) and have substantial difficulties with quitting tobacco.
- Trial name
- ACT-PT (NCT02576899)
- Testing
- Acceptance and Commitment Therapy for PTSD and Tobacco Use, Freedom From Smoking
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Urinary Incontinence, Stress, Urinary Incontinence, Urge
Group Learning Achieves Decreased Incidents of Lower Urinary Symptoms
This three-site randomized controlled trial compares the effectiveness and cost-effectiveness of a group-administered behavioral treatment program to no treatment.
- Trial name
- Gladiolus (NCT02001714)
- Testing
- Group Behavioral Treatment
- Where
- 4 sites in United States
- Volunteers
- 463 people
- Sponsor
- Ananias Diokno
Mental Health, Stress Disorders, Post-Traumatic
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
The primary study objective is to conduct a prospective, randomized controlled clinical trial that compares the effectiveness of two approaches for delivering smoking cessation treatment for veterans with posttraumatic stress…
- Conditions
- Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
- Trial name
- NCT00118534
- Testing
- Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 943 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Smoking Cessation, Stress
Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment
This open-label study will evaluate hydroxyzine, a first-generation antihistamine, combined with varenicline, to help smokers abstain from smoking during a 12-week trial period by diminishing the nausea, stress, anxiety, and…
- Conditions
- Smoking Cessation, Stress, Sleep Disturbance, Nausea
- Trial name
- HAVE (NCT04188106)
- Testing
- Varenicline Pill, Hydroxyzine Pill
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
An Investigation of Early Life Stress and Depression
The purpose of this study is to investigate brain pathways within adult females (with a history of CSA that occurred between the ages of 5-14) with and without a current diagnosis of major depressive disorder (MDD).
- Trial name
- NCT01701258
- Testing
- Amisulpride
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Insomnia
Comparing Internet and In-Person Brief Cognitive Behavioral Therapy of Insomnia
The objective of this study is to directly compare 6 sessions of in-person and Internet administered Cognitive-Behavior Therapy for Insomnia (CBTi) to a Minimal Contact control (MC), within an active duty military population to…
- Trial name
- NCT01549899
- Testing
- In-person Cognitive Behavioral Therapy of Insomnia, Internet Cognitive Behavioral Therapy of Insomnia
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Daniel J. Taylor, Ph.D.
Post Traumatic Stress Disorder, Anxiety
The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety
The Safe and Sound Protocol (SSP) is a passive acoustic intervention that is designed as a "neural exercise" to promote efficient regulation of autonomic state.
- Trial name
- NCT04999852
- Testing
- Safe and Sound Protocol, Psychotherapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Indiana University
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