Clinical trials: Stress Disorder
PTSD
Pilot Trial of Mobile Mantram Delivery
Mantram Repetition Program (MRP) is a meditation practice that involves silent repetition of a spiritual word, one-pointed attention, and slowing down. It has been shown to help reduce PTSD symptoms among Veterans.
- Trial name
- mMRP (NCT05998967)
- Testing
- Mobile Mantram Repetition Program
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Depression, Quality of Life
Internet and Telephone Support Intervention for Stroke Caregivers
This study will test a problem-solving and support intervention for caregivers of veterans with stroke. The investigators will assign caregivers to one for four groups: 4-session intervention, 8-session intervention, attention…
- Conditions
- Depression, Quality of Life, Recovery of Function, Self Efficacy
- Trial name
- NCT04348851
- Testing
- Caregiver problem-solving, Attention Control
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, Panic Attacks
Exposure Therapy For Veterans With PTSD And Panic Attacks
To evaluate the feasibility, acceptability and effectiveness of Multiple Channel Exposure Therapy-Veterans (MCET-V) as a treatment for returning service members with comorbid PTSD and panic disorder (PD).
- Trial name
- NCT01033136
- Testing
- Multiple Channel Exposure Therapy - Veterans, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Combat Disorders, Stress Disorders, Post-Traumatic
Quetiapine Augmentation for Treatment-resistant PTSD
The purpose of this study is to compare the response of veterans with PTSD without an optimal response to paroxetine to quetiapine augmentation versus placebo.
- Trial name
- NCT00292370
- Testing
- Open Label (OL) Paroxetine, Quetiapine
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- VA Office of Research and Development
Chronic Pain, Post Traumatic Stress Disorder (PTSD)
Transcranial Direct Current Stimulation Treatment for Warriors Experiencing Chronic Pain
The Veteran population has been known to deal with co-morbid chronic pain and PTSD. As a result, they use healthcare services at a higher rate than those Veterans with pain or PTSD alone which leads to an amplified burden on…
- Conditions
- Chronic Pain, Post Traumatic Stress Disorder (PTSD), Depression
- Trial name
- Warriors (NCT05254379)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Oral Mucositis
Low-level Laser Therapy on Inflammatory Mediators During Chemotherapy-induced Oral Mucositis
The aim of the study is to evaluate the effect of low-level laser therapy (LLLT) on the severity of oral mucositis (OM) and inflammatory mediators (pro- and anti-inflammatory cytokines, metalloproteinases and growth factors)…
- Trial name
- LLLTHSCT (NCT02050373)
- Testing
- Low-Level laser
- Volunteers
- 51 people
- Sponsor
- Universidade Federal de Goias
Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD)
Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence
This is a randomized, controlled trial with 50 veterans diagnosed with post-traumatic stress disorder (PTSD) and comorbid alcohol dependence.
- Trial name
- NCT01847469
- Testing
- Enhanced-Cognitive Processing Therapy-C (E-CPT-C), Zonisamide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Stress, Psychological
Audiovisual Aid Pilot Study
Little is known about perioperative stress responses and possible anxiety mitigating factors like audiovisual aids or IV sedation.
- Trial name
- NCT02506673
- Testing
- Zeiss, Cinema ProMED (audiovisual equipment), Midazolam, Skin Conductance Monitor
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hospital for Special Surgery, New York
Post-traumatic Stress Disorder
Ketamine and Prolonged Exposure in PTSD
This study aims at investigating the effectiveness of the drug, Ketamine, in combination with Prolonged Exposure (PE) therapy for people suffering from PTSD.
- Trial name
- NCT03960658
- Testing
- ketamine-enhanced prolonged exposure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Stress
Development of a Resiliency Training Program for Parents of Children With Autism Spectrum Disorder
This study has three aims: Phase I: Through focus group interviews with expert clinicians, leaders of organizations, and parents with children with ASD, this study aims to identify the psychosocial needs of parents of children…
- Trial name
- ASD (NCT02995408)
- Testing
- Relaxation Response Resiliency Program for Parents of Children with ASD
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Aspirin Resistance in Coronary Artery Disease
The purpose of this study is to evaluate possible mechanisms of aspirin resistance at a molecular level in aspirin-treated patients with coronary artery disease.
- Trial name
- NCT00753935
- Testing
- enteric-coated aspirin, Chewable aspirin
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Vanderbilt University
Urinary Incontinence, Stress
Autologous Cell Therapy for Stress Urinary Incontinence in Males Following Prostate Surgery
To study the safety and potential efficacy of Autologous Muscle Derived Cells for Urinary Sphincter Repair (AMDC-USR) for the treatment of male stress urinary incontinence (SUI) for patients that have undergone prior prostate…
- Conditions
- Urinary Incontinence, Stress, Urination Disorders, Urologic Diseases
- Trial name
- NCT02291432
- Testing
- autologous muscle-derived cells (AMDC)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cook MyoSite
Cardiac Arrest
Reoxygenation After Cardiac Arrest II (REOX II Study)
The broad objective of this study is to test the association between hyperoxia exposure after resuscitation from cardiac arrest and outcome.
- Trial name
- REOX II (NCT02698826)
- Testing
- Protocol for rapid FiO2 optimization
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- The Cooper Health System
Stress Disorder, Post Traumatic
D-cycloserine and Virtual Reality Exposure to Treat Iraq War Veterans With PTSD
This study will determine whether a combination of virtual reality exposure therapy and D-cycloserine will reduce post-traumatic stress disorder symptoms in Iraq war veterans.
- Trial name
- NCT00356278
- Testing
- D-Cycloserine, Alprazolam, Virtual Reality Exposure Therapy
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Emory University
Stress Disorders, Post-Traumatic
Meditation Interventions for Treatment of PTSD in Veterans
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which results in serious impairments in interpersonal, occupational and social functioning.
- Trial name
- VMP (NCT01548742)
- Testing
- Mindfulness-Based Stress Reduction (MBSR), Present-Centered Group Therapy (PCGT)
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Stress Neuroadaptation in Tobacco Dependence
The objective of the current study is to evaluate the validity of the No Shock, Predictable Shock, Unpredictable Shock (NPU) stressor task for use as a surrogate endpoint to predict short-term clinical outcomes among smokers…
- Trial name
- NCT03262233
- Testing
- nicotine
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- University of Wisconsin, Madison
Post-traumatic Stress Disorder
Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can…
- Trial name
- NCT00700999
- Testing
- Paroxetine
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
PTSD
Safety and Efficacy Study of TNX-102 SL in Subjects With Military-Related PTSD and Related Conditions
This is a 12-week, multicenter, randomized, double-blind, placebo-controlled, fixed-dose, parallel-group study that will investigate the efficacy and safety of two doses of TNX-102 SL -a sublingual formulation of cyclobenzaprine.
- Trial name
- AtEase (NCT02277704)
- Testing
- TNX-102 SL
- Where
- 23 sites in United States
- Volunteers
- 245 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Female Stress Urinary Incontinence
Treatment of Stress Urinary Incontinence Via Smartphone
The purpose of this study is to determine whether treatment of stress urinary incontinence (SUI) via smartphone is effective.
- Trial name
- NCT01848938
- Testing
- Smartphone treatment with PFMT
- Where
- Sweden
- Volunteers
- 123 people
- Sponsor
- Umeå University
Caregiver Burden, Alzheimer Disease
Reducing Burden in Care Partners of Community-Dwelling Persons With Dementia and Oropharyngeal Dysphagia
The goal of this clinical trial is to learn if a newly-created website tool, called WeCareToFeedDysphagia, helps to reduce feelings of burden in care partners of patients with Alzheimer's disease and related dementias (AD/ADRD)…
- Conditions
- Caregiver Burden, Alzheimer Disease, Dementia, Oropharyngeal Dysphagia
- Trial name
- NCT06557863
- Testing
- WeCareToFeedDysphagia web tool
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
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