Clinical trials: Stress Disorder
Cannabis, Post Traumatic Stress Disorder
Nabilone in Cannabis Users With PTSD
Despite the prevalence of cannabis use among the PTSD population and self-reports that it is used to help cope with PTSD symptoms, the direct effects of cannabis on PTSD symptomology are unknown.
- Trial name
- NCT03251326
- Testing
- Nabilone, Cannabis, Propranolol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder, Depression
Zambia Common Elements Treatment Approach Pilot Study
This is a randomized controlled trial (RCT) evaluating the effectiveness of an alcohol brief intervention alone compared to the brief intervention plus an evidence-based psychotherapy (CETA) in reducing alcohol misuse and…
- Conditions
- Alcohol Use Disorder, Depression, Post-traumatic Stress Disorder, HIV/AIDS
- Trial name
- ZCAP (NCT03966885)
- Testing
- Brief Intervention, Common Elements Treatment Approach (CETA)
- Where
- Zambia
- Volunteers
- 160 people
- Sponsor
- Columbia University
Hyperglycemia
Sitagliptin in Non-Diabetic Patients Undergoing General Surgery
The purpose of this study is to compare sitagliptin with a placebo for the prevention of high glucose after general surgery.
- Trial name
- NCT02741687
- Testing
- Sitagliptin, Supplemental insulin (insulin lispro), Supplemental insulin (insulin aspart)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Anxiety Disorders, Depression
LGBTQ-affirmative CBT for Youth
This study will adapt LGBTQ-affirmative cognitive behavior therapy (CBT) - previously only used with adults - for youth aged 12-17 years.
- Conditions
- Anxiety Disorders, Depression, LGBTQ
- Trial name
- NCT05408858
- Testing
- LGBTQ-affirmative cognitive behavioral group therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Yale University
Anxiety, Anxiety Disorders
Anxiety, Inflammation, Stress, and Cannabinoids
This study investigates whether the anxiolytic effects and anti-inflammatory properties of cannabis vary as a function of the ratio of CBD to THC, with the goal that these effects may shed light on the mixed data linking cannabis…
- Conditions
- Anxiety, Anxiety Disorders, Anxiety Generalized, Anxiety Chronic
- Trial name
- NCT03491384
- Testing
- Cannabis (smoked flower, ingested edible)
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Colorado, Boulder
Osteoarthritis, Knee
Validation of a Stress Device for the Knee
X-rays are the most frequently used imaging test when evaluating the knee for joint replacement. They are non-invasive, safe and cost effective.
- Trial name
- NCT02444663
- Testing
- Clinician Valgus, Clinician Varus, Device Valgus - 0 Newton
- Volunteers
- 9 people
- Sponsor
- Oxford University Hospitals NHS Trust
Carpal Tunnel Syndrome
Non-invasive CTS Device Clinical Trial
Sham-controlled, multi-center and remote patient-centered randomized controlled clinical trial to investigate the efficacy of a novel non-invasive, unobtrusive study device in reducing symptoms of carpal tunnel syndrome (CTS).
- Trial name
- NCT03498287
- Testing
- Study Device
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Pressure Profile Systems, Inc.
Stress Disorders, Post-Traumatic, Tinnitus
Network Dysregulation Among Individuals With Comorbid Tinnitus and PTSD
Evaluation of the overlap between tinnitus-related distress and symptoms of Post Traumatic Stress Disorder (PTSD), to identify functional covariance among resting-state networks among individuals with tinnitus and PTSD
- Trial name
- NCT03702166
- Testing
- Cognitive Processing Therapy (CPT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Alzheimer Disease, Dementia
CONFIDENCE-AI Financial Education for Caregivers (CONFIDENCE-AI)
The intervention being tested, CONFIDENCE-AI is a refined version of the original CONFIDENCE intervention made to reduce psychological financial strain and improve management of out-of-pocket care costs while increasing caregiver…
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burden, Financial Stress
- Trial name
- CONFIDENCE-AI (NCT06134180)
- Testing
- CONFIDENCE-AI
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Posttraumatic Stress Disorder, Alcohol Use
CBT Texts for PTSD & Hazardous Drinking (Project Better)
The research study seeks to refine and test a brief, self-directed, intervention for individuals from the general public with PTSD and co-occurring HD that can be delivered via text-messaging.
- Trial name
- NCT05372042
- Testing
- CBT Text Messages
- Where
- United States
- Volunteers
- 505 people
- Sponsor
- University of Washington
Alzheimer Disease, Dementia
Efficacy of Caregiver Training Program in Enhancing Caregiver and Patient Outcomes
As part of Phase II of the NIH SBIR grant, the study will conduct a randomized controlled clinical trial in which the MapHabit system (MHS) will offer a caregiver training product in adjunct.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burden, Assistive Technology
- Trial name
- NCT05527405
- Testing
- The MapHabit System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- MapHabit, Inc.
Hypothermia, Newborn
Kangaroo Mother Care to Prevent Hypothermia in Term Infants
The overall hypothesis is that better adherence to Kangaroo Mother Care (KMC) in combination with existing WHO thermoregulation care will reduce the incidence of moderate hypothermia (32-36 degrees C) or severe hypothermia (<32.0…
- Trial name
- NCT02189759
- Testing
- Continuous Kangaroo Mother Care to one hour after birth, Standard Kangaroo Mother Care to one hour after birth, Continuous Kangaroo Mother Care to discharge
- Where
- Zambia
- Volunteers
- 375 people
- Sponsor
- University of Alabama at Birmingham
Post-traumatic Stress Disorder
Acceptance and Commitment Therapy to Improve Social Support for Veterans With PTSD
Veterans with PTSD often have impaired social relationships and poor social support. The negative outcomes associated with poor social support are of particular concern for Veterans with PTSD, who often perceive the world to be…
- Trial name
- ACT-SS (NCT04567680)
- Testing
- Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD, Present-Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 107 people
- Sponsor
- VA Office of Research and Development
PostTraumatic Stress Disorder
Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness
This is a multisite, randomized, blinded, sham-procedure-controlled study to evaluate the efficacy of right-sided stellate ganglion block (SGB) on the acute symptomatology of Post traumatic Stress Disorder (PTSD), evaluated by…
- Trial name
- NCT03077919
- Testing
- Ropivacaine
- Where
- 3 sites in United States, Germany
- Volunteers
- 113 people
- Sponsor
- RTI International
Osteoarthritis
A Biomarker Stress Test for Detection of Early Osteoarthritis
Veterans have much higher risk of osteoarthritis (OA) then the general population. Knee OA is common among Veterans and is a leading cause of disability.
- Trial name
- NCT02593864
- Testing
- Variable-Stiffness Shoe
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- VA Palo Alto Health Care System
Pre-hypertension, Hypertension
Effects of the Beta-blocker Nebivolol (Bystolic) on Subjects With High Normal Blood Pressure and/or a Family History of Hypertension
The investigators aim to evaluate subjects at high risk of future development of hypertension, those with a family history of hypertension and/or that already have high normal(SBP 120-139 mmHg or DBP 80-89 mmHg) blood pressure.
- Trial name
- NCT01202175
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Post Traumatic Stress Disorder, Alcohol Abuse
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD
Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid…
- Trial name
- NCT03852628
- Testing
- 2mg Buprenex and 380mg Vivitrol
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Posttraumatic Stress Disorder, Tonic Immobility Response
Development and Evaluation of a Tonic Immobility Focused Psychoeducational Intervention
A randomized controlled trial is planned to evaluate a brief, web-based intervention intended to educate about tonic immobility (TI) within a sample of those who experienced TI in the context of a traumatic event.
- Trial name
- TIP (NCT05113277)
- Testing
- Tonic Immobility Psychoeducation (TIP), Health Education Training (HET)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Florida State University
Urinary Incontinence
Comparison of Surgical Procedures to Reduce Urinary Stress Incontinence
The primary aim of this clinical trial is to compare the treatment success for two surgical procedures that are frequently used and have similar cure rates, yet have not been compared directly to each other in a large, rigorously…
- Trial name
- SISTEr (NCT00064662)
- Testing
- Burch Modified Tanagho, Autologous Fascia Sling
- Where
- 9 sites in United States
- Volunteers
- 655 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Depression, Unipolar, Posttraumatic Stress Disorder
SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project
Despite carrying the vast majority of the global mental disorder burden, 75% of adults with mental disorders in Low and Middle Income Countries have no access to services.
- Conditions
- Depression, Unipolar, Posttraumatic Stress Disorder, Trauma
- Trial name
- SMART-DAPPER (NCT03466346)
- Testing
- Fluoxetine, Interpersonal Psychotherapy
- Where
- 3 sites in Kenya
- Volunteers
- 2,162 people
- Sponsor
- University of California, San Francisco
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