Clinical trials: Stress Disorders, Post-Traumatic
PTSD
Cortisol Augmentation of a Psychological Treatment in Warfighters With Post Traumatic Stress Disorder (PTSD)
This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the…
- Trial name
- NCT01090518
- Testing
- Prolonged Exposure therapy, Hydrocortisone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Bronx VA Medical Center
Posttraumatic Stress Disorder
Low-dose Cortisol in Chronic Posttraumatic Stress Disorder
The aim of this prospective, double-blind, placebo-controlled, cross-over study is to determine the therapeutic efficacy of low-dose cortisol for symptoms of chronic posttraumatic stress disorder.
- Trial name
- NCT00362661
- Testing
- Cortisol
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Fibromyalgia, PTSD
Group Therapy for Fibromyalgia:the Effectiveness of Mindfulness -Based VS Cognitive-behavioral Therapy
This study was conducted as part of a collaboration between the Maccabi Health Fund and Bar Ilan University. Fibromyalgia is a chronic pain disorder, highly co-morbid with depression, stress, and anxiety.
- Conditions
- Fibromyalgia, PTSD, Depression, Stress
- Trial name
- NCT04265196
- Testing
- cognitive behavioral group therapy, Mindfulness-based group therapy
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Bar-Ilan University, Israel
Thyroid Neoplasms, Neoplasm
EMDR Integrative Group Protocol and Individual Treatment for Patients With Cancer: A Pilot Study
The main aim of the present process-outcome study is to evaluate the feasibility and the effects of an EMDR-IGTP-OTS group intervention on a sample of people with cancer, by using a process-outcome study design, with repeated…
- Conditions
- Thyroid Neoplasms, Neoplasm, Post-traumatic Stress Disorder (PTSD), Psychological Distress
- Trial name
- NCT07447089
- Testing
- EMDR-IGTP-OTS
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Università Cattolica di Milano
Posttraumatic Stress Disorders
Ifenprodil Tartrate Treatment of Adolescents With Post-traumatic Stress Disorder: a Double-blind, Placebo-controlled Trial
Accumulating evidence suggests a key role of the N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of post-traumatic stress disorder (PTSD).
- Trial name
- NCT01896388
- Testing
- Ifenprodil Tartrate
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Chiba University
Self Harm, Personality Disorders
Extreme Challenges - Psychopathology & Treatment Experiences Among Severly Selfharming Inpatients in Norway
Patients who self-harm are a heterogeneous population. Outpatient treatments structured for borderline personality disorder are often recommended and hospitalization kept to a minimum.
- Conditions
- Self Harm, Personality Disorders, Psychosis, Developmental Disorder
- Trial name
- NCT03768674
- Testing
- Assessment of diagnoses, functioning and health services
- Where
- Norway
- Volunteers
- 1,640 people
- Sponsor
- Oslo University Hospital
Brain Injury Traumatic Mild, Post-traumatic Stress Disorder
Brain Health & Wellness Classes for Veterans With Traumatic Brain Injury
This study is testing the usefulness of two types of Brain Health \& Wellness classes for Veterans with a history of concussion to improve mental health.
- Trial name
- NCT06150196
- Testing
- Mindfulness-based Stress Reduction class, Brain Health Education class
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- East Bay Institute for Research and Education
Complex Post-Traumatic Stress Disorder (CPTSD)
RECONNECT - Treatments for Complex PTSD
Complex PTSD (CPTSD) is a new diagnosis for which no established gold-standard treatment(s) yet exists. In this trial, three psychotherapies, Prolonged Exposure (PE), Eye Movement Desensitization and Reprocessing (EMDR), and…
- Trial name
- NCT07863089
- Testing
- Prolonged Exposure, EMDR, ESTAIR
- Volunteers
- 225 people
- Sponsor
- University of Copenhagen
Post Traumatic Stress Disorder, Suicidal Ideation
Integration of PE & Coping Long-Term With Active Suicide Program for PTSD & Suicide Risk in Military Families
The purpose of this study is to develop an innovative, safe, acceptable, feasible, and efficacious integrated CLASP-PE intervention and to Collect pilot data to evaluate the preliminary evidence of the promise of the…
- Trial name
- NCT04284410
- Testing
- CLASP-PE arm
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Disease, Hepatitis C
Evaluating a Telehealth Treatment for Veterans With Hepatitis C and PTSD
The main objective of this proposal is to develop and test the efficacy of two interventions (a telehealth and face-to-face intervention) designed to improve quality of life, self-care, motivation to engage in healthcare, and…
- Conditions
- Chronic Disease, Hepatitis C, Stress Disorders, Post-Traumatic
- Trial name
- NCT00333710
- Testing
- Individual psychotherapy, Telehealth Intervention
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- US Department of Veterans Affairs
Post-Traumatic Stress Disorder
Enhancing Equitable and Effective (E-3) Post Traumatic Stress Disorder (PTSD) Disability Assessment
This project evaluated the impact of semi-structured, standardized interviews on the initial PTSD C\&P on the examination.
- Trial name
- E-3PTSD (NCT00699660)
- Testing
- CAPS/WHODAS, Nonstructured Interview
- Where
- 11 sites in United States
- Volunteers
- 406 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder
Early EMDR Following Covid-19 Critical Illness: A Feasibility Trial
Primary objective is to evaluate the feasibility of delivering an online early Eye Movement Desensitisation Reprocessing (EMDR) Recent Traumatic Events Protocol (R-TEP) to patients who have survived Covid-19 related critical…
- Conditions
- Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder, Anxiety Disorders, Depression
- Trial name
- Cov-EMERALD (NCT04455360)
- Testing
- Eye Movement Desensitisation and Reprocessing Recent traumatic Event Protocol
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
PTSD, Depression
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10).
- Conditions
- PTSD, Depression, Parent-Child Relations
- Trial name
- NCT06262178
- Testing
- Parenting-STAIR Modular (PSTAIR-M)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- New York University
Anxiety Disorders, Mood Disorders
Efficacy of Sleep Interventions for Posttraumatic Stress Disorder (PTSD)
The purpose of this research study is to evaluate and compare the effects of experimental treatments aimed at improving insomnia and nightmares in men and women military veterans between the ages of 18 and 60 years old, and who…
- Conditions
- Anxiety Disorders, Mood Disorders, Insomnia, Nightmares
- Trial name
- EASI-P (NCT00393874)
- Testing
- Behavioral Sleep Intervention, Prazosin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Post Traumatic Stress Disorder
Written Document to Assist Family During Decision of Withholding and Withdrawing Life-sustaining Therapies in the Intensive Care Unit
Relatives of patients in situation of withholding and withdrawing life-sustaining therapies often show post traumatic stress disorder (PTSD) (60%)[1].
- Trial name
- LATA (NCT02329418)
- Testing
- Explaining withholding and withdrawing life-sustaining therapies along with a written document, Explaining withholding and withdrawing life-sustaining therapies following standard procedure
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Grenoble
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Alcohol Use Disorder, Depression
Project VALOR: Veteran Stress and Wellbeing
This study will examine the efficacy of an internet-based brief intervention designed to reduce risky behavior veterans as the move into their second year post-Army.
- Trial name
- NCT06095817
- Testing
- Internet Delivered Brief Intervention (IDBI)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cornell University
Psychosis, Complex Post-Traumatic Stress Disorder
Psychological Interventions for Complex PTSD And Schizophrenia-Spectrum Disorder: PICASSO Trial
Psychosis is a highly distressing mental health condition, affecting up to 3% of the population. Conceptually, it has much in common with complex post-traumatic stress disorder (CPTSD), a recently introduced condition in ICD-11.
- Conditions
- Psychosis, Complex Post-Traumatic Stress Disorder, Schizophrenia
- Trial name
- PICASSO (NCT05281640)
- Testing
- Affect Dysregulation intervention, Negative Self Concept intervention, Disturbed Relationships intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- Edinburgh Napier University
Post-Traumatic Stress Disorder
Risperidone in the Treatment of PTSD in Women Survivors of Domestic Abuse and Rape Trauma
This medical study is an assessment of clinical response in women with Posttraumatic Stress Disorder (PTSD) due to domestic violence or rape trauma when treated with risperidone.
- Trial name
- NCT00208182
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Creighton University
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center