Clinical trials: Stress Disorders, Posttraumatic
Depression, Unipolar, Posttraumatic Stress Disorder
SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project
Despite carrying the vast majority of the global mental disorder burden, 75% of adults with mental disorders in Low and Middle Income Countries have no access to services.
- Conditions
- Depression, Unipolar, Posttraumatic Stress Disorder, Trauma
- Trial name
- SMART-DAPPER (NCT03466346)
- Testing
- Fluoxetine, Interpersonal Psychotherapy
- Where
- 3 sites in Kenya
- Volunteers
- 2,162 people
- Sponsor
- University of California, San Francisco
Posttraumatic Stress Disorder
Group vs. Individual Cognitive Processing Therapy for Combat-related PTSD
The purpose of this study is to conduct a randomized controlled trial to compare group and individual CPT-C for the treatment of PTSD in OIF/OEF military personnel.
- Trial name
- NCT02173561
- Testing
- Group Cognitive Processing Therapy-Cognitive Only, Individual Cognitive Processing Therapy-Cognitive Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Post-Traumatic Stress Disorders
KIDNET vs Meditation/Relaxation - a Dissemination Randomized Controlled Trial for the Treatment of Traumatized Children After War in Sri Lanka
The purpose of this study is to assess the efficacy of KIDNET versus a Meditation/Relaxation protocol in treating traumatized children when applied by locally trained teacher counsellors as well as the effectiveness and adequacy…
- Trial name
- NCT00564317
- Testing
- KIDNET, Meditation/Relaxation
- Where
- Sri Lanka
- Volunteers
- 48 people
- Sponsor
- University of Konstanz
Post Traumatic Stress Disorder
A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD
PTSD occurs in up to 17% of post-9/11 US Service Members and is associated with long-term functional impairment, family problems, unemployment, and suicidality.
- Trial name
- COOPERATE (NCT06990191)
- Testing
- Partnered Prolonged Exposure (PPE), Prolonged Exposure (PE)
- Where
- 4 sites in United States
- Volunteers
- 420 people
- Sponsor
- United States Department of Defense
Post-Traumatic Stress Disorder
tDCS Plus Virtual Reality for PTSD
This study tests the efficacy of combining non-invasive brain stimulation, called transcranial direct current stimulation (tDCS), with virtual reality exposure as a treatment for Veterans with chronic posttraumatic stress…
- Trial name
- TAVRE (NCT03372460)
- Testing
- Active stimulation, Virtual Reality (VR)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Borderline Personality Disorder, Post-Traumatic Stress Disorders
Outcome of Crisis Intervention for Subjects With Borderline Personality Disorder or Post-Traumatic Stress Disorder
Dr. Laddis will test a hypothesis about the nature and the management of behavioral crises in patients with borderline personality disorder (BPD) or post-traumatic stress disorder (PTSD).
- Trial name
- NCT00269139
- Testing
- Crisis resolution
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Laddis, Andreas, M.D.
Chronic Post-Traumatic Stress Disorder
G.R.I.T. - Goal-directed Resilience Intervention Training
This research program has addressed three reactive adaptations evident in pain, PTSD, and obesity. In this project, the focus will be on PTSD as a model of stimulus-based reactive responses to unpredictability or threat, and the…
- Trial name
- GRIT (NCT03890029)
- Testing
- Intervention Training, Control Condition
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Morehouse School of Medicine
Post-traumatic Stress Disorder
Effectiveness of Mindfulness-based Internet Intervention Still Me
The aim of the study is to assess the effectiveness of a mindfulness-based internet intervention for post-traumatic stress disorder symptoms.
- Trial name
- Still-Me (NCT04333667)
- Testing
- Intervention group
- Where
- Lithuania
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Depressive Disorder, Major, Post Traumatic Stress Disorder
A Randomized Control Trial Treating Depression With Yoga and Coherent Breathing Versus Walking in Veterans
The proposed study addresses a gap regarding the need for effective Major Depressive Disorder (MDD) treatments and the 40% of individuals treated with antidepressant medications that do not achieve full remission.
- Trial name
- NCT03489122
- Testing
- yoga, walking
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Depression, Anxiety
Study of Effectiveness of Mental Health Interventions Among Torture Survivors in Southern Iraq
1. That the psychotherapeutic intervention - Components-Base Interventions (CBI) - is effective in reducing the severity of mental health symptoms experienced by torture survivors in Southern Iraq. 2.
- Conditions
- Depression, Anxiety, Post-Traumatic Stress Disorder
- Trial name
- NCT01177072
- Testing
- Cognitive Processing Therapy, Components-Based Intervention
- Where
- Iraq
- Volunteers
- 342 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Post Traumatic Stress Disorder PTSD
Nurse-Led PTSD Treatment in Primary Care
Purpose of the Study Post-traumatic stress disorder (PTSD) is a common and serious condition, but many people cannot get the help they need because there are not enough mental health specialists (like psychologists or…
- Trial name
- NCT07430657
- Testing
- NurseNET, Referral to PTSD Treatment
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
PTSD - Post Traumatic Stress Disorder
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
The goal of the REVEAL PTSD study is to test how well the Senseye DT works as a diagnostic test for Post-traumatic Stress Disorder (PTSD) in adults 18 and older who are experiencing one or more symptoms that might be related to…
- Trial name
- NCT07280065
- Testing
- Senseye Diagnostic Tool (DT), Clinician Administered PTSD Scale for DSM-5, Revised Version
- Where
- 6 sites in United States, Australia
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Senseye, Inc.
Post-Traumatic Stress Disorder (PTSD)
Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD
Leveraging veterans' intimate relationships during treatment for posttraumatic stress disorder (PTSD) has the potential to concurrently improve PTSD symptoms and relationship quality.
- Trial name
- CBCT-OT RCT (NCT06194851)
- Testing
- Oxytocin nasal spray, Saline nasal spray, Brief Cognitive-Behavioral Conjoint Therapy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
PTSD
Prolonged Exposure (PE) Treatment for Post Traumatic Stress Disorder (PTSD) 20 Minutes Versus 40 Minutes
Comparing the efficacy of 40 minutes PE treatment to 20 minutes of the same treatment
- Trial name
- NCT00229307
- Testing
- Prolonged Exposure (PE) therapy
- Where
- Israel
- Volunteers
- 39 people
- Sponsor
- Sheba Medical Center
Posttraumatic Stress Disorder
Piloting Acute Care to Primary Care Linkage of Safety Net Patients
This pilot study will evaluate the implementation of a stepped care intervention that combines Cognitive-Behavioral Therapy, Motivational Interviewing, psychotropic medications, and information technology innovations at a level 1…
- Trial name
- TSOS III (NCT01347541)
- Testing
- Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Washington
PTSD
Concentrated Exposure Therapy for Post-traumatic Stress Disorder - a Cohort Study
Post-traumatic stress disorder (PTSD) is a prevalent and disabling condition. Trauma-focused psychotherapy, including cognitive behavioural therapy (CBT), are among the recommended first-line treatment alternatives.
- Trial name
- NCT05598099
- Testing
- Concentrated cognitive behavioral therapy
- Where
- Norway
- Volunteers
- 42 people
- Sponsor
- Haukeland University Hospital
PTSD - Post Traumatic Stress Disorder, PTSD (Childbirth-Related)
The New Empowerment After eXposure to Trauma (NEXT) Study
The NEXT Study is a randomized controlled pilot examining the feasibility and acceptability of a revised perinatal PTSD protocol.
- Trial name
- NEXT (NCT07175025)
- Testing
- Narrative Exposure Therapy (NET)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Indiana University
Post-Traumatic Stress Disorder
Biopsychosocial Effectiveness of Exercise Trainings in Earthquake Survivors With Post-Traumatic Stress Disorder
In study, the investigators aim to demonstrate the effectiveness of biopsychosocial-based exercise approach in post-traumatic stress disorder of physiotherapists in post-earthquake disaster management.
- Trial name
- NCT06390618
- Testing
- Aerobic Exercise (AE) Group, Combined Exercise (CE) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Erkin Oğuz SARI
Panic Disorder, Generalized Anxiety Disorder
Transdiagnostic Versus Diagnosis-specific Cognitive-behavioral Therapy
The primary aim of the pilot study is to investigate the feasibility of conducting a randomized controlled trial (RCT) comparing the effects of transdiagnostic and diagnosis-specific cognitive-behavioral therapy (CBT) for…
- Conditions
- Panic Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT05249543
- Testing
- Unified protocol, Diagnosis-specific cognitive-behavioral therapy
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Karolinska Institutet