Clinical trials: Stress Disorders, Traumatic, open to volunteers
CPTSD, Compelx Post-traumatic Stress Disorder
The Effectiveness of Guided Written Exposure Therapy for Complex PTSD in Adolescents
This study aims to examine the effectiveness of group Guided Written Exposure Therapy for Complex Post-Traumatic Stress Disorder (GWE-C) among Chinese adolescents through a randomized controlled trial.
- Trial name
- NCT07325734
- Testing
- Group Guided Written Exposure Therapy for CPTSD (GWE-C), Supportive Group
- Where
- 4 sites in China
- Volunteers
- 130 people
- Sponsor
- Peking University
Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis and limited treatment options following failure of first-line therapy.
- Trial name
- MATTERS-2 (NCT07711067)
- Testing
- Whole-body hyperthermia, Standard-of-Care Systemic therapy
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 95 people
- Sponsor
- ElmediX
Stress Disorders, Post-Traumatic, PTSD
Service Dogs and Prolonged Exposure Therapy for Military-Connected PTSD
This study investigates the impact of Service Dog partnership on the effectiveness of Prolonged Exposure Therapy. We will learn whether Service Dog partnership in combination with Prolonged Exposure Therapy treatment can help…
- Conditions
- Stress Disorders, Post-Traumatic, PTSD, Animal-Human Bonding, Combat Stress Disorders
- Trial name
- SERVES+ (NCT06723834)
- Testing
- Psychiatric Service Dog, Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- University of Arizona
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders
Efficacy of an EMDR App for PTSD and SUD
The current proposal is aimed to confirm the efficacy of this novel therapeutic method (autonomous eye movement desensitization and reprocessing; A-EMDR) in a patient group (PTSD and SUD), and to assess the feasibility of the…
- Trial name
- NCT07146633
- Testing
- A-EMDR, Treatment as Usual (TAU)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre for Addiction and Mental Health
PTSD - Post Traumatic Stress Disorder, Stress Disorder, Post Traumatic
Evaluation of the Effect of an Emergency Department Information Video on the Risk of Post-Traumatic Stress Disorder 30 Days After an Emergency Visit.
Post-traumatic stress disorder (PTSD) is a psychological disorder characterized by the re-experiencing of distressing symptoms, avoidance of traumatic memories and physiological hyperarousal in people who have been exposed to a…
- Trial name
- VISU (NCT06755606)
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stress, Emotional, Stress-related Mental Disorders
School-Based Intervention to Enhance Resilience and Stress Coping in Rural Chinese Adolescents
This study aims to evaluate the effectiveness of school-based psychological interventions in improving stress resilience and coping skills among adolescents in rural China.
- Trial name
- EASY (NCT07115186)
- Testing
- Psychoeducation, guided written therapy, wait-list condition
- Where
- China
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Peking University
PTSD, Post-traumatic Stress Disorder
Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder
The goal of this study is to test whether anesthesia-induced experiences can help alleviate symptoms of PTSD in an (1) open-label trial (Phase I) and (2) single-center double-blind, randomized, active-comparator (dose-controlled)…
- Trial name
- IDEA_PTSD (NCT06577636)
- Testing
- Propofol
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Stanford University
PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults
Acute Effects of Estradiol Administration on Brain Function During Fear Learning
The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones.
- Conditions
- PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults, Post Menopausal Women
- Trial name
- EstroFearGen (NCT07737613)
- Testing
- estradiol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
CBD, Cannabidiol
Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response.
- Conditions
- CBD, Cannabidiol, Stress, Acute Stress Reaction
- Trial name
- NCT07069478
- Testing
- Stress Intervention
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Post Traumatic Stress Disorder
Effect of Attentional Therapy on Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is associated with an attentional bias towards negative stimuli, which is supposed to contribute to the development and the maintenance of the disorder.
- Trial name
- BATRAUMA (NCT05331534)
- Testing
- Eye-tracking assisted attention control training (ACTo), Attention control training (ACT)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Lille
Heat Stress, Physiological Stress
Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave
Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself.
- Trial name
- NCT06842953
- Testing
- Simulated indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
PTSD - Post Traumatic Stress Disorder, PTSD
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
The Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD, PTSD Symptoms, PTSD, Post Traumatic Stress Disorder
- Trial name
- Redefine (NCT07570654)
- Testing
- COMP360 psilocybin
- Where
- 10 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- COMPASS Pathways
PTSD, Subclinical PTSD
The Effectiveness of Written Exposure Therapy for PTSD
Study 1: The goal of this study is to use a pilot RCT to assess the effectiveness of Written Exposure Therapy (WET) and a mindfulness-based app (MBA) for managing PTSD and comorbid insomnia in China.
- Trial name
- NCT05421494
- Testing
- written exposure therapy-revised version, minimal contact control
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Peking University
Critical Illness Recovery, Behavioral Health Concerns
Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot
This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU survivors.
- Conditions
- Critical Illness Recovery, Behavioral Health Concerns, Anxiety, Depression - Major Depressive Disorder
- Trial name
- NCT07390786
- Testing
- Behavioral Treatment
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical University of South Carolina
PTSD
Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD
The purpose of this study is to understand if we can improve the treatment for posttraumatic stress disorder (PTSD). We are looking into whether the combination of Stellate Ganglion Block (SGB) treatment and Cognitive Processing…
- Trial name
- NCT06570213
- Testing
- Cognitive Processing Therapy, Stellate Ganglion Block
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Rush University Medical Center
Post Traumatic Stress Disorder
Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.
Purpose: About 6.4% of the U.S. population suffers from posttraumatic stress disorder (PTSD). Trauma-focused psychotherapies are generally effective in PTSD, but responses vary greatly across individuals and PTSD subpopulations.
- Trial name
- IV Allo PTSD (NCT07079761)
- Testing
- Experiment 1: Three-day aversive conditioning, extinction, and extinction retention testing paradigm, Allopregnanolone (Allo) with 6% USP Dexolve (sulfobutyl ether-beta-cyclodextrin sodium salt) in 0.9% saline for IV infusion will be provided by the University of California, Davis, GMP manufacturer., Experiment 1. Three-day aversive conditioning, extinction, and extinction retention testing paradigm
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder (MDD, Anxiety Disorder, Generalized
Serotonin Variants & Gut Microbiota in Mental Health
This observational pilot study investigates whether a broad panel of genetic variants relevant to the serotonin pathway (including serotonergic system, methylation cycle, intestinal barrier integrity, and inflammatory response…
- Conditions
- Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder
- Trial name
- NCT07634458
- Testing
- SNP Genotyping and Gut Metagenomics
- Volunteers
- 30 people
- Sponsor
- Neurobiologix
Anxiety
Transcranial Alternating Current Stimulation (tACS) for the Treatment of Anxiety in Veterans: An Open-Label Pilot Study
Transcranial alternating current stimulation (tACS) in a wearable brain stimulation device that delivers a low intensity, pulsed, alternating current via scalp electrodes.
- Trial name
- NCT07288008
- Testing
- Transcranial alternating current stimulator
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Birmingham VA Health Care System
PTSD
Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder
This study aims to implement and evaluate a more timely approach to post-traumatic stress disorder (PTSD) diagnosis and management, entitled Patient Outcome Reporting for Timely Assessments of Life with Post-Traumatic Stress…
- Trial name
- PORTAL-PTSD (NCT06479447)
- Testing
- PORTAL-PTSD
- Where
- 2 sites in United States
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- University of Chicago
PTSD, Depression
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10).
- Conditions
- PTSD, Depression, Parent-Child Relations
- Trial name
- NCT06262178
- Testing
- Parenting-STAIR Modular (PSTAIR-M)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- New York University