Clinical trials: Stress Fractures
Acute Stress Reaction, Acute Stress Disorder
Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)
This study will examine the safety and efficacy of TNX-102 SL to reduce ASR symptoms and behavioral changes among patients presenting to the emergency department (ED) after motor vehicle collision (MVC).
- Conditions
- Acute Stress Reaction, Acute Stress Disorder, Neurocognitive Function, Post-traumatic Stress
- Trial name
- OASIS (NCT06636786)
- Testing
- Cyclobenzaprine HCl
- Where
- 9 sites in United States
- Volunteers
- 180 people
- Sponsor
- University of North Carolina, Chapel Hill
Smoking, Smoking Behaviors
Translational Research Center in Lung Cancer Disparities (TRACER) Project 2
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
- Conditions
- Smoking, Smoking Behaviors, Smoking Cessation, Stress Reaction
- Trial name
- TRACER (NCT05490251)
- Where
- 2 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Laparoscopic Cholecystectomy Surgery
Attenuate the Stress Response in Laparoscopic Cholecystectomy
Aims of this study are to compare the effectiveness of dexmedetomidine versus fentanyl-midazolam in attenuating hemodynamic stress response during laparoscopic cholecystectomy (mainly HR).
- Trial name
- NCT07425444
- Testing
- Dexmedetomidine, Fentanyl- midazolam
- Volunteers
- 50 people
- Sponsor
- Assiut University
Investigating the Importance of the Subjective Psychedelic Experience
Subjective Experience Following Psilocybin
The purpose of this study is to determine the importance of the acute subjective experience induced by psilocybin (the primary component of "magic mushrooms") in facilitating positive outcomes.
- Trial name
- SEP-1 (NCT06768944)
- Testing
- Psilocybin high-dose, Psilocybin low-dose, Risperidone 1 MG
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stress Fracture
Pharmacokinetic and PHarmacodynamic Analysis and Evaluation of Teriparatide (PTH 1-34) Between Sexes
To test for a difference in the pharmacokinetics (PK) and pharmacodynamics (PD) of teriparatide (PTH 1-34), between healthy male and female volunteers matched to military recruits in training.
- Trial name
- PHAB (NCT04921124)
- Testing
- Teriparatide
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Healthy Adult Participants, Acute Stress Reaction
Breathwork and Stress: Investigating the Mechanisms of Action and Effectiveness of Breathing Interventions in Modulating the Psychophysiological Response to Acute Stress Test
This study investigates whether the psychophysiological benefits of breathing exercises are driven by a specific physiological rhythm (6 breaths per minute) or by the general psychological experience of performing a structured…
- Conditions
- Healthy Adult Participants, Acute Stress Reaction, Stress Biomarkers, Healthy
- Trial name
- NCT07529379
- Testing
- Coherent Breathing (6 bpm)
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Laparoscopy, Colorectal Disease
The Stress Response in Laparoscopic Colorectal Surgery and Its Role in the Development of the Enhanced Recovery Program.
Keyhole bowel surgery provides the patient with an improved outcome following surgery in comparison to more traditional surgery requiring a large cut.
- Conditions
- Laparoscopy, Colorectal Disease, Stress Response
- Trial name
- NCT01128088
- Where
- United Kingdom
- Volunteers
- 133 people
- Sponsor
- University of Surrey
Cognition, Stress Reaction
rTMS to Enhance Cognitive Performance and Promote Resilience
The purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rTMS) for improving cognitive functions such as attention and memory as…
- Trial name
- NCT04123496
- Testing
- rTMS
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Fractures, Sprain
Epidemiology of Incidents and Accidents in Sport. Influence of Moisture.
sports accidents and incidents are relatively frequent. We hypothesize that the pursuit of good hydration, including days without training or competition could prevent their occurrence
- Conditions
- Fractures, Sprain, Stress Fractures, Aches
- Trial name
- NCT02346786
- Testing
- eau minérale d'Aix-Les-Bains, tap water
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Rhumatologique et Thermal
Breast Cancer Female, Stress Reaction
Stress Reactivity Among African American Breast Cancer Survivors
Despite increased access to early detection and the availability of more effective therapeutic strategies, African American women continue to experience excess rates of morbidity and mortality from breast cancer.
- Trial name
- NCT03881085
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Medical University of South Carolina
Depression, Anxiety
Effect of General and Non-general Anesthesia on Perioperative Depression or Anxiety
Perioperative depression and/or anxiety play a critical role in patient presentation, satisfaction and outcomes. The aim of this study is to assess the level of perioperative depression and/or anxiety in patients with…
- Trial name
- NCT05315648
- Testing
- anesthesia approach (general anesthesia or non-general anesthesia)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Stress Response
Remifentanil and Stress Hormones Response
Perioperative adequate analgesia reduces neuroendocrine stress response and postoperative complications. Because opioids are the most effective parenteral drugs to control pain and stress response, in this prospective randomized…
- Trial name
- NCT03378674
- Testing
- Remifentanil Injectable Product
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Stress Fracture, Ultrasound Therapy
Comparison of Ultrasound and X-ray as Screening Tests for Diagnosis of Lower Extremity Stress Fracture.
Hypothesis: Diagnostic ultrasound is an appropriate screening test for acute stress fracture in the lower extremity and is superior to x-ray.
- Conditions
- Stress Fracture, Ultrasound Therapy, Musculoskeletal Ultrasound
- Trial name
- NCT03116360
- Testing
- Diagnostic Ultrasound
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Pneumonia, Aspiration, Gastric Content
Point-of-care Gastric Ultrasound for Fracture Surgery
Although there are fasting guidelines offered by the American Society of Anesthesiology (ASA) for managing preoperative patient assessment, some patients may need to be more cautious about the risk of aspiration.
- Conditions
- Pneumonia, Aspiration, Gastric Content, Fractures, Bone
- Trial name
- NCT05728242
- Testing
- Gastric ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Haseki Training and Research Hospital
Stress Fracture
US vs MRI for Stress Injuries
The primary purpose of this study is to determine whether or not there is a correlation between MRI and ultrasound for the diagnosis of lower limb stress injuries.
- Trial name
- NCT05876897
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ryan Kruse
Septic Shock, Stress Response
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessened by reducing the stress…
- Conditions
- Septic Shock, Stress Response, Cerebral Hemodynamics
- Trial name
- NCT06169475
- Testing
- Dexmedetomidine Hydrochloride, Esmolol Hydrochloride
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Xinchen Wang
Pain, Pain After Surgery
Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma
Severe limb trauma often requires the use of a tourniquet to stop life-threatening bleeding. While tourniquets are essential for saving lives, prolonged interruption of blood flow may lead to tissue ischemia, nerve injury, and…
- Conditions
- Pain, Pain After Surgery, Phantom Limb Pain After Amputation, Military Combat Stress Reaction
- Trial name
- TOURNI-PAIN (NCT07475871)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Pain, Postoperative, Analgesic Requirement
Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy
Laparoscopic Cholecystectomy is the treatment of choice for patients with symptomatic gall stones. For pain relief following laparoscopic cholecystectomy both intraperitoneal and intravenous administration of lignocaine has been…
- Conditions
- Pain, Postoperative, Analgesic Requirement, Stress Response, Return of Bowel Activity
- Trial name
- NCT01717222
- Testing
- Intraperitoneal Lignocaine, Intravenous Lignocaine
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Rupture of the Rotator Cuff
Microfracture in Rotator Cuff Injury Repair
The hypothesis is that microfractures in the footprint of the humerus will aid to improve the tendon healing to the bone. The aim of the study is to investigate whether the use of microfractures at the footprint of the rotator…
- Trial name
- NCT02097901
- Testing
- Microfracture, NO microfracture
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Inflammation, Postoperative Pain
Impact of Suppressing Surgical Stress Reaction on Postoperative Inflammation.
Patients undergoing surgery under opioid free general anesthesia (OFA) are monitored with antinociceptive devices like NOL or ANI that measures sympathetic activity but are invisible for the attending anesthesiologist .
- Trial name
- NCT04195009
- Testing
- major surgery under opioid free anesthesia without regional anesthesia
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- AZ Sint-Jan AV