Clinical trials: Stress Fractures
Lateral Ligament Repair, Talar Cartilage Lesion
Microfracture Technique for Talar Articular Cartilage Lesions With or Without Lateral Ligament Repairment
To study the clinical efficacy of microfracture combined with lateral ligament repairment for cartilage lesions of talus through the comparison between microfracture with and without lateral ligament repairment.
- Conditions
- Lateral Ligament Repair, Talar Cartilage Lesion, Microfracture
- Trial name
- NCT03064399
- Testing
- without lateral ligament repairment, lateral ligament repairment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Autism Spectrum Disorder, Adverse Childhood Experiences
Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition
Using a metabolomics approach in combination with eye-tracking data, this research study proposes to gather evidence from two interrelated body systems (gut and brain) in order to assess how the microbiome is involved in stress…
- Conditions
- Autism Spectrum Disorder, Adverse Childhood Experiences, Stress Reaction
- Trial name
- NCT06269614
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Musculoskeletal Pain, Musculoskeletal Injury
The Diagnostic Accuracy of the Clinical Examination
This study examines the diagnostic accuracy of the clinical examination as compared to MRI findings
- Trial name
- NCT03850470
- Testing
- clinical examination, MRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- High Point University
Acute Stress Reaction
Neuronal Correlates of Neurexan® Action in Mildly to Moderately Stressed Probands
The purpose of this study is to explore the effect of Neurexan® on the brain response when participants undergo an emotional stressful condition in verum compared to placebo.
- Trial name
- NEURIM (NCT02602275)
- Testing
- Neurexan
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Biologische Heilmittel Heel GmbH
Stoke, Dementia
Evaluation of Usage and Efficacy of the 656 Online Platform for Reducing Caregiver Stress in Chinese Caregivers
This study aimed to assess the efficacy of a new online platform, 656 Online Platform, in Hong Kong in reducing caregiver stress and enhancing caregiver preparedness and competence of caring for older adults with stroke…
- Conditions
- Stoke, Dementia, Fall and Fractures Prevention
- Trial name
- NCT06771557
- Testing
- 656 Online Platform
- Where
- Hong Kong
- Volunteers
- 287 people
- Sponsor
- Hong Kong Metropolitan University
DDH
Supracondylar Femur Fracture After DDH
incidence of ipsilateral Supracondylar femoral fractures after cast removal for Developmental dysplasia of the hip (DDH) surgery
- Trial name
- NCT06142305
- Testing
- DDH surgery and casting
- Volunteers
- 300 people
- Sponsor
- Assiut University
Ankle Fractures, Post-traumatic Osteoarthritis
Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle. Research suggests that ankle arthritis develops following ankle fracture due, in part, to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP FPA CT (NCT05209347)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Sponsor
- University of Iowa
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Abdominal Hysterectomy, Postoperative Pain
Effect of TAP Block on Stress Hormones
Random allocation of patients in two groups; Tap block group (T group) and control group (C group). All patients will receive standard general anesthesia and postoperative pain management.
- Trial name
- NCT03443271
- Testing
- TAP Block with Bupivicaine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Stress Fracture Foot, Stress Fracture Ankle
Detecting and Assessing Leg and Foot Stress Fractures Using Photon Counting CT
Stress fractures (fatigue or insufficiency fracture) are caused by the mismatch between bone strength and chronic stress applied to the bone. The vast majority of these fractures occur in the lower extremity.
- Conditions
- Stress Fracture Foot, Stress Fracture Ankle, Stress Fracture of Tibia, Stress Fracture Metatarsal
- Trial name
- FootPCCT (NCT06024798)
- Testing
- Photon-Counting-Computed-Tomography
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Balgrist University Hospital
Osteoporotic Fracture
Effectiveness or Orthopedic Intervention in Osteoporosis Management After a Fracture of the Hip With Cost-Benefit Analysis
Patients who present with fragility fractures are consistently under-evaluated and under-treated for underlying osteoporosis. This point of care represents a lost opportunity to prevent future fractures.
- Trial name
- NCT02239523
- Testing
- Letter Group, Intervention Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Shaare Zedek Medical Center
Erector Spinae Plane Block, Systemic Immune-inflammatory Index
Investigation of the Effect of Erector Spinae Plane Block on Systemic Immuno-Inflammatory Index
Erector spinae plane block (ESPB) is a novel interfascial block technique first described by Forero in 2016. It has been reported to be effective in various clinical indications.
- Conditions
- Erector Spinae Plane Block, Systemic Immune-inflammatory Index, Breast Cancer
- Trial name
- NCT06954324
- Testing
- Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Namik Kemal University
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Stress Reaction, Stress Related Disorder
Research on the Effects of Combined Neurostimulation Protocols on Stress
The study examines the effects of the combined use of two different non-invasive brain stimulation (NIBS) techniques targeting the DLPFC on stress reactivity and recovery.
- Conditions
- Stress Reaction, Stress Related Disorder, Major Depressive Disorder
- Trial name
- NCT03722095
- Testing
- active tDCS, iTBS
- Where
- Belgium
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Ghent
Osteochondral Lesion of Talus, Microfractures
Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus
The goal of this clinical trial is to learn if combined local injection of platelet rich plasma (PRP) gel adds clinical efficacy to isolated arthroscopic microfracture in treatment of osteochondral lesion of the talus (OLT).
- Conditions
- Osteochondral Lesion of Talus, Microfractures, Platelet Rich Plasma
- Trial name
- NCT06358807
- Testing
- Arthroscopic microfracture with intraoperative local PRP gel injection, Isolated microfracture
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Stress Response
Magnesium Versus High Dose Fentanyl in Endotracheal Intubation
this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation
- Trial name
- NCT04544163
- Testing
- Magnesium sulfate- Fentanyl, Fentanyl 4Mcg/kg, Fentanyl 2Mcg/kg
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- National Cancer Institute, Egypt
Alcohol Use Disorder, Alcoholism
Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
During the first funding period (1st FP) we investigated the impact of acute and chronic stress (Trier Social Stress Test, TSST) on Pavlovian-to-instrumental transfer (PIT).
- Conditions
- Alcohol Use Disorder, Alcoholism, Stress Reaction, Ostracism
- Trial name
- ReCoDe (NCT06256952)
- Testing
- PIT paradigm, social exclusion (Cyberball task), Saliva samples
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Post Operative Pain, Stress Response
Effects of Erector Spinae Plane and Caudal Block on Postoperative Stress Response
Inguinal hernia surgery is the most common practice of pediatric surgeons in their clinical practice. As these operations are usually day case procedures, maintaining adequate analgesia is an important component of perioperative…
- Conditions
- Post Operative Pain, Stress Response, Erector Spinae Plane Block, Caudal Block
- Trial name
- NCT05633173
- Testing
- Ultrasound-guided erector spinae plan block, Ultrasound-guided caudal block
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Cartilage Defect
ChonDux for Filling Full Thickness Cartilage Defects in the Femoral Condyle of the Knee
The use of ChonDux Cartilage Repair system for the treatment of single cartilage lesions in the femoral condyle of the knee. The primary outcome measure is degree of lesion fill at 6 months.
- Trial name
- NCT01110070
- Testing
- ChonDux
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 21 people
- Sponsor
- Zimmer Biomet