Clinical trials: Stress Response
Posttraumatic Stress Disorder, Major Depressive Disorder
Predicting SSRI Efficacy in Veterans With PTSD
This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) or depression are most likely to show a positive response to selective…
- Trial name
- SSRI (NCT04183205)
- Testing
- LDAEP, sertraline
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Stress Reaction
Effect of Location of Tetanic Stimuli on Photoplethysmogram
The effect of the location of tetanic stimulus on photoplethysmography signals will be studies in patients under general anesthesia.
- Trial name
- NCT03648853
- Testing
- Tetanic Stimulus
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Fear Conditioning
Influence of Escitalopram on Fear Conditioning
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking an antidepressant medication. This medication is called Lexapro (Escitalopram).
- Trial name
- NCT01398514
- Testing
- Escitalopram
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Post Traumatic Stress Disorder
A Pilot Dose-Response Biomarker Study of Brexpiprazole Treatment in PTSD
Determine if brexpiprazole treatment will be associated with a dose-dependent reduction in resting pupil diameter as a reflection of locus coeruleus (LC) norepinephrine (NE) neuron target engagement in a group of subjects with…
- Trial name
- NCT02934932
- Testing
- Brexpiprazole
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Post-traumatic Stress Disorder
Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can…
- Trial name
- NCT00700999
- Testing
- Paroxetine
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hyperthermia
Skin Surface and Intradermal Temperature Responses to Heat Stress
The purpose of this study is to compare surface and intradermal skin temperature responses to heat stress with and without evaporative and convective cooling.
- Trial name
- NCT06593067
- Testing
- Control, Fan, Fan and Water Spray
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Cognition, Stress Reaction
rTMS to Enhance Cognitive Performance and Promote Resilience
The purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rTMS) for improving cognitive functions such as attention and memory as…
- Trial name
- NCT04123496
- Testing
- rTMS
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Non PTSD, PTSD
Neurobiology of Sleep and Sleep Treatment Response in Returning Veterans
The overarching objectives of this study are: 1) To investigate the neurobiology of posttraumatic stress disorder (PTSD) during Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM) sleep relative to wakefulness; 2) To…
- Trial name
- NOSSTIP (NCT01637584)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Stress Disorders, Post-traumatic
Analyzing Female Trauma Exposed Responses to a Medication
This purpose of this study is to look at the safety of the experimental drug GSK561679 as well as its effects on PTSD symptoms, thinking and memory, startle reaction, stress hormones, and mental health symptoms in comparison to…
- Trial name
- AFTER (NCT01814332)
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- VA Office of Research and Development
PTSD
Optimizing Treatment Response in VA Specialized Intensive/Inpatient PTSD Programs
Prolonged Exposure therapy (PE) is a first-line treatment for posttraumatic stress disorder; however few VA patients receive this treatment.
- Trial name
- NCT03533608
- Testing
- Group PE
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- VA Office of Research and Development
Enhanced Recovery After Surgery, Spine Surgery
Enhanced Recovery After Spine Surgery
Enhanced recovery pathways (ERP) after surgery have been shown to decrease length of stay and perioperative complications in a range of surgical specialties.
- Trial name
- NCT02949518
- Testing
- Enhanced Recovery Pathway (ERP) for Spine
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Congenital Heart Disease in Children, Inflammatory Response
STeroids to REduce Systemic Inflammation After Infant Heart Surgery
This study's objective is to determine the pharmacokinetics (PK)/pharmacodynamics (PD), safety and efficacy of methylprednisolone in infants undergoing heart surgery with cardiopulmonary bypass.
- Trial name
- STRESS (NCT03229538)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 23 sites in United States
- Volunteers
- 1,263 people
- Sponsor
- Kevin Hill
Alcohol Use Disorder
Oxytocin and Stress Response in Alcohol Use Disorder
Individuals with alcohol use disorder (AUD) will complete one functional Magnetic Resonance Imaging (fMRI) scanning visit. Prior to the scan, individuals will receive a nasal spray of either 24 international units (IU) of…
- Trial name
- NCT03610633
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Anxiety, Anxiety Disorders
Anxiety, Inflammation, Stress, and Cannabinoids
This study investigates whether the anxiolytic effects and anti-inflammatory properties of cannabis vary as a function of the ratio of CBD to THC, with the goal that these effects may shed light on the mixed data linking cannabis…
- Conditions
- Anxiety, Anxiety Disorders, Anxiety Generalized, Anxiety Chronic
- Trial name
- NCT03491384
- Testing
- Cannabis (smoked flower, ingested edible)
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Colorado, Boulder
Tibial Fractures, Leg Injuries
Light Therapy in the Treatment of Leg Pain
The purpose of this study is to apply Anodyne therapy to active duty soldiers, who have shin splints, to evaluate healing time and effectiveness.
- Trial name
- MilCAM (NCT00253981)
- Testing
- Monochromatic Near-Infrared Light Energy (MIRE)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Samueli Institute for Information Biology
Stress
Comparison of Two Behavioral Treatments for Stress Reduction
Currently there are 2 popular stress reduction courses that are widely used in the US. Although they use somewhat similar techniques, it is currently unknown whether or not they work the same way, or if they are similarly…
- Trial name
- NCT00625807
- Testing
- RR, MBSR
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Severe Sepsis
Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis
Cell-free hemoglobin can be measured in the plasma of patients with sickle cell anemia, hemodialysis, after red blood cell transfusion, and in patients with sepsis.
- Trial name
- ACROSS (NCT01739361)
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University
Gastrostomy
Transversus Abdominis Plane Block on Stress Response
This study evaluates the effect of transversus abdominis plane(TAP) block combined with general anesthesia on perioperative stress response in patients undergoing radical gastrectomy.
- Trial name
- NCT03035916
- Testing
- Transversus abdominis plane block, Epidural anesthesia, control
- Where
- China
- Volunteers
- 91 people
- Sponsor
- Jilin University