Clinical trials: Stress-Related Disorders
COVID-19, Pregnancy Complications
Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic
The purpose of this study is to assess the health and wellbeing of pregnant and recently pregnant women during the COVID-19 pandemic using an online survey.
- Conditions
- COVID-19, Pregnancy Complications, Mental Health Wellness 1, Anxiety
- Trial name
- NCT04385238
- Testing
- This is an online survey with no intervention.
- Where
- United States
- Volunteers
- 6,894 people
- Sponsor
- Pregistry
Stress, Physiological, Infertility
Evaluation of the Impact of Stress on IVF Outcome
The purpose of this study is to determine if physiological measures of stress, measured by the non-invasive OTO device, are significantly correlated with IVF outcome.
- Conditions
- Stress, Physiological, Infertility, Stress, Psychological
- Trial name
- NCT05589571
- Where
- 43 sites in United States
- Volunteers
- 240 people
- Sponsor
- Inception Fertility Research Institute, LLC
Posttraumatic Stress Disorder
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
The goal of this clinical trial is to learn if MDMA in combination with therapy is safe and effective in people with chronic, treatment-resistant PTSD.
- Trial name
- NCT01793610
- Testing
- Comparator Dose (40mg) MDMA HCl, Active Dose 2 (100 mg) MDMA HCl, Active Dose 1 (125 mg) MDMA HCl
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Resilient Pharmaceuticals
PTSD - Post Traumatic Stress Disorder, PTSD
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
The Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD, PTSD Symptoms, PTSD, Post Traumatic Stress Disorder
- Trial name
- Redefine (NCT07570654)
- Testing
- COMP360 psilocybin
- Where
- 10 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- COMPASS Pathways
Post-Traumatic Stress Disorder, PTSD
Software as a Medical Device for the Treatment of Patients With PTSD
To evaluate the efficacy and safety of Software as a Medical Device in patients with Post-Traumatic Stress Disorder (PTSD)
- Trial name
- NCT06589505
- Testing
- Software as a Medical Device
- Where
- 35 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Otsuka Medical Devices Co., Ltd. Japan
Stress Disorders, Post-Traumatic, Combat Disorders
Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken)
This study will provide preliminary estimates of safety and efficacy of the NightWare digital therapeutic system (iPhone + Apple watch + proprietary application) for the treatment of nightmare disorder associated with…
- Conditions
- Stress Disorders, Post-Traumatic, Combat Disorders, Ptsd, Nightmare
- Trial name
- TNT/NW (NCT03795987)
- Testing
- NightWare Therapeutic System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NightWare
Workplace Stress, Mental Health
The Effects of Stress & Irregular Shift Hours on First Responders
First Responders are expected to maintain high-performance levels under extreme conditions. However, constant intense workplace stress, physical work demands, and irregular shift hours are taking a severe toll on frontline…
- Conditions
- Workplace Stress, Mental Health, HRV, EEG
- Trial name
- NCT05659277
- Testing
- Workplace Stress and Irregular shift hours
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Endominance
Intermediate AMD
A Clinical Trial Evaluating the Safety and Efficacy of a New Light Combination Therapy Addressing Intermediate AMD
The proposed clinical investigation wants primary to validate the safety of the innovative light therapy approach and in second priority provide insight and confirmations on therapeutic effect.
- Trial name
- retinaSEES-PoC (NCT06557369)
- Testing
- reSEES
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Oculox Technologies SA
Depressive Disorder, Anxiety Disorders
AI to Support Mental Health Case Management Providers
The goal of this clinical trial is to assess the effectiveness of an artificial intelligence (AI) platform for case managers in a nonprofit health system specializing in mental health and substance use disorder.
- Conditions
- Depressive Disorder, Anxiety Disorders, Substance Use Disorders, Post Traumatic Stress Disorder
- Trial name
- NCT06280170
- Testing
- Artificial Intelligence platform for case managers
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Eleos Health
Posttraumatic Stress Disorder
Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective and reducing PTSD symptoms in veterans with chronic PTSD.
- Trial name
- NCT01211405
- Testing
- Low dose MDMA-assisted therapy, Medium dose MDMA-assisted therapy, Full dose MDMA-assisted therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Resilient Pharmaceuticals
Post Traumatic Stress Disorder
Brexpiprazole as Combination Therapy With Sertraline in the Treatment of Adults With Post-traumatic Stress Disorder
This will be a 12-week, multicenter, randomized, double-blind trial evaluating the efficacy, safety, and tolerability of fixed-dose brexpiprazole + sertraline combination treatment in adult subjects with post-traumatic stress…
- Trial name
- NCT04174170
- Testing
- Brexpiprazole, Sertraline
- Where
- United States
- Volunteers
- 591 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Work-Related Stress
Informal Caregivers at Work - Phase 2
Mental health problems are rising among children and adolescents. This may not only impact the child's level of daily functioning but also close family members.
- Trial name
- PPJob-II (NCT06441461)
- Testing
- Primary informal caregiver at work.
- Where
- Denmark
- Volunteers
- 4,386,647 people
- Sponsor
- Team Working Life Denmark
PTSD, Generalized Anxiety Disorder
Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSD
The aim of this study is to obtain data on the feasibility of the Senseye Diagnostic Tool (DT) to assess the presence and severity of post-traumatic stress disorder (PTSD) symptoms.
- Conditions
- PTSD, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT05717439
- Testing
- CAPS-5-R, Senseye DT
- Where
- 5 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Senseye, Inc.
PTSD - Post Traumatic Stress Disorder
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
The goal of the REVEAL PTSD study is to test how well the Senseye DT works as a diagnostic test for Post-traumatic Stress Disorder (PTSD) in adults 18 and older who are experiencing one or more symptoms that might be related to…
- Trial name
- NCT07280065
- Testing
- Senseye Diagnostic Tool (DT), Clinician Administered PTSD Scale for DSM-5, Revised Version
- Where
- 6 sites in United States, Australia
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Senseye, Inc.
Parenting Practices, Self Efficacy
Talk Parenting Education Program II
The goal of this clinical trial is to learn whether Talk Parenting, a voice-based program delivered through an Amazon Echo Dot (Alexa), can help parents and caregivers of children ages 3-5 years improve challenging bedtime and…
- Conditions
- Parenting Practices, Self Efficacy, Stress, Child Behavior
- Trial name
- TP2 (NCT07462052)
- Testing
- The Talk Parenting Program
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
PTSD
OM and Trauma Study
The primary purpose of this study is to use an unblinded, uncontrolled, 1-month interventional single group pilot study, to assess the possibility of Orgasmic Meditation practice being used as a possible intervention for PTSD.
- Trial name
- OMTP (NCT05577377)
- Testing
- Orgasmic Meditation
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Institute of OM Foundation
Stress Disorders, Post-Traumatic
A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)
To evaluate the safety, efficacy and tolerability of brexpiprazole (with placebo) as monotherapy or combination therapy with Zoloft (sertraline) in adults with PTSD.
- Trial name
- NCT03033069
- Testing
- Brexpiprazole, Sertraline
- Where
- 54 sites in United States
- Volunteers
- 336 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Post Traumatic Stress Disorder
Effectiveness of Sana Treatment in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to assess the effectiveness of the Sana Device when added to Treatment as Usual in participants with a diagnosis of post-traumatic stress disorder (PTSD)
- Trial name
- NCT05319405
- Testing
- Sana Device
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Sana Health
Substance Use Disorders, PTSD
A Mobile App for Peer-led Seeking Safety
Peer support is historically prominent for substance use disorder (SUD), such as the world-wide model of Alcoholics Anonymous and other 12-step groups.
- Conditions
- Substance Use Disorders, PTSD, Trauma, Emotional Dysfunction
- Trial name
- NCT03846115
- Testing
- Peer-Led Seeking Safety app, Control app
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Treatment Innovations
Major Depressive Disorder (MDD, Anxiety Disorder, Generalized
Serotonin Variants & Gut Microbiota in Mental Health
This observational pilot study investigates whether a broad panel of genetic variants relevant to the serotonin pathway (including serotonergic system, methylation cycle, intestinal barrier integrity, and inflammatory response…
- Conditions
- Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder
- Trial name
- NCT07634458
- Testing
- SNP Genotyping and Gut Metagenomics
- Volunteers
- 30 people
- Sponsor
- Neurobiologix