Clinical trials: Stress-Related Disorders
Post-Traumatic Stress Disorder
Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder
The primary purpose of this study is to investigate the efficacy of neurofeedback (NF) of real-time functional magnetic resonance imaging (rt-fMRI) data of the amygdala with regards to the reduction of post-traumatic stress…
- Trial name
- PTSD (NCT03574974)
- Testing
- Experimental Feedback, Control Feedback
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Yale University
Traumatic Brain Injury, Post-traumatic Stress Disorder
Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury
The scientific objective of this program is to meet the rehabilitation needs of combat wounded Veterans with mild to moderate Traumatic Brain Injury (TBI) via telerehabilitation and determine the effect of this modality of care…
- Trial name
- NCT00676182
- Testing
- Telerehabilitation
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Bisexuality, Homosexuality
Skills to Empower Affirmative Men
Participants are Vietnamese national. Over the course of the study activities, approximately 184 self-identified Vietnamese national gay and bisexual men ages 18 and above living in HCMC, Viet Nam, as well as 10 key informants…
- Conditions
- Bisexuality, Homosexuality, HIV Infections
- Trial name
- VINA STEAM (NCT05732675)
- Testing
- "VINA STEAM" (Skills to Empower Affirmative Men)
- Where
- Vietnam
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Florida State University
Posttraumatic Stress Disorder
MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder
The goal of this clinical trial is to compare MDMA-assisted therapy to placebo with therapy in people with chronic, treatment-resistant posttraumatic stress disorder (PTSD).
- Trial name
- NCT00090064
- Testing
- Midomafetamine HCl, Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Resilient Pharmaceuticals
Cocaine Related Disorders
Stress and Medication Effects on Cocaine Cue Reactivity
Stressful situations and cues associated with cocaine can lead to craving in cocaine dependent individuals. The purpose of this study is to determine whether guanfacine or modafinil are effective in reducing stress and cue…
- Trial name
- NCT00613015
- Testing
- Guanfacine, Modafinil
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Medical University of South Carolina
Alzheimer Disease and Related Dementias, Dementia Alzheimers
MASC: Reducing Stress for Caregivers
Building on limitations of prior research, the investigators proposed to develop the Mindful and Self-Compassionate Care Program (MASC) to help caregivers of persons with Alzheimer Disease and Related Dementias (ADRD) manage…
- Trial name
- MASC (NCT05847153)
- Testing
- MASC
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obstructive Sleep Apnea
A Randomized Cross Over Trial of Two Treatments for Sleep Apnea in Veterans With Post-Traumatic Stress Disorder
Sleep disturbances are cardinal features of Veterans with post traumatic stress disorder (PTSD). In particular, obstructive sleep apnea is reported to occur more frequently in patients with PTSD compared to those without PTSD and…
- Trial name
- NCT01569022
- Testing
- CPAP, MAD
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Pregnancy Related, Burnout, Professional
The 4th Trimester Initiative: The Impact of Parental Support on Pregnant Trainee Wellbeing
The goal of this clinical trial is to determine the impact of a parental support package for new trainee mothers which focuses on mentorship, lactation, and sleep, and access to perinatal care.
- Conditions
- Pregnancy Related, Burnout, Professional, Wellness, Psychological
- Trial name
- NCT06014892
- Testing
- Snoo smart bassinet, Willow wearable breast pump, Maven Clinic on-demand perinatal consultation
- Where
- 7 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
PTSD
Treatment of PTSD in Residents of Battered Women's Shelters
This is a study comparing a new treatment (HOPE) to supportive therapy in the treatment of PTSD in residents of battered women's shelters.
- Trial name
- HOPE (NCT02398227)
- Testing
- HOPE, PCT
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- The University of Akron
Alzheimer Disease, Dementia
Technology and Family Thriving Study
The purpose of this project is to test the impact of different forms of technology (virtual reality vs. video chat) on quality of life and family relationships in older adults who reside in senior living communities and an adult…
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burnout, Quality of Life
- Trial name
- Thrive (NCT05150990)
- Testing
- Virtual Reality, Video Chat
- Where
- 27 sites in United States
- Volunteers
- 186 people
- Sponsor
- University of California, Santa Barbara
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02655354)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management
- Where
- 24 sites in United States
- Volunteers
- 635 people
- Sponsor
- University of Washington
Post-traumatic Headache, PTSD
Cognitive-Behavior Therapy for Posttraumatic Headache
The overall purpose of the study is to compare two talk therapies (Clinic-Based Cognitive Behavioral Therapy and Cognitive Processing Therapy-Cognitive Only) for the treatment of posttraumatic headache (PTHA) and co-morbid…
- Trial name
- NCT02419131
- Testing
- Behavioral Headache Therapy, Cognitive Processing Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder, Substance Use Disorders
Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
This project will provide initial feasibility and efficacy data for the implementation of Narrative Exposure Therapy (NET) to urban, at-risk youth.
- Trial name
- POWER-NET (NCT03737383)
- Testing
- Narrative Exposure Therapy
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Alcohol Use Disorder
The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use Disorders
To use pregnenolone (PREG; 300; 500mg) daily versus placebo (PLA) as a probe to assess the role of neuroactive steroids in individuals with alcohol use disorder (AUD).
- Trial name
- NCT03872128
- Testing
- Pregnenolone300, Pregnenolone500
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Stress Disorders, Post-Traumatic
HIRREM in Military Personnel
The purpose of this study is to evaluate the effects associated with the use of in-office High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) for participants with symptoms of military-related…
- Trial name
- NCT03230890
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Posttraumatic Stress Disorder
Placebo Controled Clinical Trial Using Topiramate To Treat Posttraumatic Stress Disorder (PTSD) Patients.
The study is 12-week randomized placebo controlled trial compared to topiramate to treat patients with posttraumatic stress disorder, according to DSM-IV criteria.
- Trial name
- NCT00725920
- Testing
- Topiramate
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- Federal University of São Paulo
Obstructive Sleep Apnea, PTSD
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke.
- Conditions
- Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT02641496
- Testing
- CBT-OSA, Sleep Education
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Post Traumatic Stress Disorder
Stress, Emotion Regulation, and Alcohol in Women Veterans
The purpose of the study "Stress, Emotion Regulation, and Alcohol in Women Veterans" is to learn about the effects of negative emotion and stress on behavior (including alcohol use) among women Veterans, including women with and…
- Trial name
- SERA (NCT04393623)
- Testing
- Cognitive Reappraisal, Psychoeducation
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
Brexpiprazole as Combination Therapy With Sertraline in the Treatment of Adults With Post-traumatic Stress Disorder
This will be a 12-week, multicenter, randomized, double-blind trial evaluating the efficacy, safety, and tolerability of fixed-dose brexpiprazole + sertraline combination treatment in adult subjects with post-traumatic stress…
- Trial name
- NCT04174170
- Testing
- Brexpiprazole, Sertraline
- Where
- United States
- Volunteers
- 591 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Post-Traumatic Stress Disorder
Orvepitant (GW823296) in Adult Post Traumatic Stress Disorder
This is a 12-week, randomized, multicenter, double-blind, placebo controlled, fixed-dose parallel group study to assess the efficacy and safety of orvepitant (60 mg/day) versus placebo in subjects with a diagnosis of…
- Trial name
- NCT01000493
- Testing
- orvepitant
- Where
- 26 sites in United States
- Volunteers
- 132 people
- Sponsor
- GlaxoSmithKline