Clinical trials: Stress-Related Disorders
Post Traumatic Stress Disorder
Physiological Augmentation of Mindfulness Meditation
The purpose of the study is to compare the efficacy of a physiologically-augmented breath-focused mindfulness-based intervention to reduce symptoms of dissociation that are associated with psychological trauma, as well as…
- Trial name
- PAMM (NCT02754557)
- Testing
- Breath-Focused Meditation, Physiological Feedback
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Emory University
Alcoholism, Depression
Naltrexone & SSRI in Alcoholics With Depression/PTSD
The purpose of this study is to evaluate the efficacy of naltrexone in combination with an SSRI to reduce alcohol consumption in alcoholic patients with comorbid PTSD and depression.
- Conditions
- Alcoholism, Depression, PTSD
- Trial name
- NCT00338962
- Testing
- paroxetine, desipramine, Naltrexone
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Yale University
Combat Disorders
Prospective Study of Veteran Health in Previously Deployed Soldiers
Background: Previous deployments like that to the Persian Gulf in 1991 produced veterans with post-deployment symptom-based health problems with no medical explanation.
- Trial name
- NCT00285246
- Where
- 2 sites in United States
- Volunteers
- 838 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder
Improving Veteran Adherence to Treatment for PTSD Through Partnering With Families
Evidence-based psychotherapies (EBP) for PTSD, such as Prolonged Exposure (PE), result in clinically significant symptom relief for many.
- Trial name
- NCT03256227
- Testing
- Family Supported Prolonged Exposure, Standard Prolonged Exposure
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, PTSD
D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18…
- Trial name
- NCT01157429
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tulane University School of Medicine
Stress Disorders, Posttraumatic, Tobacco Use Disorder
Nicotine Patch Pretreatment for Smoking Cessation in PTSD
This study seeks to evaluate the relationship between PTSD, abstinence, and factors associated with relapse in the context of a randomized, clinical smoking cessation trial.
- Trial name
- NCT00625131
- Testing
- Nicotine, Cognitive Behavioral Therapy for Smoking Cessation, Bupropion Sustained Release (SR)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
PTSD
Yoga and Physical Activity for Veterans
Posttraumatic stress disorder (PTSD) is a major health problem for the nation's Veterans, leading to significant physical and mental health morbidity and mortality.
- Trial name
- NCT03509909
- Testing
- Hatha yoga, Supportive physical activity
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorders, Combat Disorders
Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
In comparison to the general population, U.S. military and Veterans are at an increased risk for developing both substance use disorders (SUD) and Post Traumatic Stress Disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
- Trial name
- COPE (NCT01338506)
- Testing
- Concurrent Treatment with Prolonged Exposure (COPE)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Combat Disorders, Stress Disorders, Post-Traumatic
A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD
The primary aim of this project is to examine whether administration of D-Cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist that has been shown to facilitate fear extinction, enhances the therapeutic…
- Trial name
- NCT00371176
- Testing
- Exposure therapy, D-Cycloserine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- US Department of Veterans Affairs
Anxiety, Depression
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Psychological treatments are effective, but take a long time and can be burdensome. Therefore, avenues to optimize behavioral treatments are needed.
- Conditions
- Anxiety, Depression, Personality Disorders, Trauma and Stress-related Disorders
- Trial name
- NCT02573246
- Testing
- Cognitive Restructuring, rTMS
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Duke University
Alcohol Dependence
Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and Relapse
To test the preliminary efficacy of 16.0 mg of Prazosin daily versus placebo in treatment seeking alcohol dependent individuals.
- Trial name
- NCT00585780
- Testing
- Prazosin Tablet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Siblings, Childhood Cancer
SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children With Cancer
This study aims to address barriers to psychosocial care for siblings of children with cancer by piloting a group-based telehealth program for adolescent siblings of youth with cancer.
- Conditions
- Siblings, Childhood Cancer, Pediatric Cancer, Posttraumatic Stress Disorder
- Trial name
- R03 CA259898 (NCT04889755)
- Testing
- SibACCESS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alzheimer Disease, Caregiver Stress Syndrome
Learning and Improving Alzheimer's Patient-Caregiver Relationships Via Smart Healthcare Technology
The purpose of this project is to develop a monitoring, modeling, and interactive recommendation solution (for caregivers) for in-home dementia patient care that focuses on caregiver-patient relationships.
- Trial name
- NCT04536701
- Testing
- Mood Monitoring and Behavioral Recommendation System
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Alcohol Dependence
CRF1 Antagonist GSK561679 in Alcoholism
Objective: To evaluate GSK561679, an orally available, brain penetrant selective CRH1 antagonist for its ability to reduce alcohol craving in recently detoxified alcohol dependent women in response to stress or alcohol-associated…
- Trial name
- NCT01187511
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Post Traumatic Stress Disorder
Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD
The purpose of this study is to quantify the therapeutic efficacy and role of trained service dogs on socio-emotional functioning among military veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT03245814
- Testing
- Service Dog
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Post-Traumatic Stress Disorder, Chronic Low Back Pain
Yoga and Mantram for Chronic Pain and PTSD
PTSD is prevalent among Veterans and is associated with physical and functional impairments in addition to PTSD symptoms. Veterans with PTSD experience more chronic pain and pain-related functional limitations than Veterans…
- Conditions
- Post-Traumatic Stress Disorder, Chronic Low Back Pain, Chronic Neck Pain
- Trial name
- NCT03816007
- Testing
- Yoga and Mantram Repetition, Veteran Calm
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective at reducing PTSD symptoms in people with at least severe PTSD.
- Trial name
- NCT03485287
- Testing
- Midomafetamine HCl, Manualized therapy
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Resilient Pharmaceuticals
Alcohol Use Disorders (AUD)
Mifepristone for the Prevention of Relapses of Alcohol Drinking
The goal of this study is to determine if, under stress, alcohol drinking is reduced using mifepristone
- Trial name
- NCT02243709
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Brown University
Posttraumatic Stress Disorder, Depression
A Study of Sertraline to Prevent PTSD
The broad, long-term objectives of this proposal are to prevent the emergence of posttraumatic stress and depressive symptoms in children admitted for an acute burn, reconstructive surgery, or non-burn injury.
- Trial name
- NCT00182078
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital