Clinical trials: Stress-Related Disorders
Family Relations, Psychological Trauma
Multifamily Healing Spaces for Family Resilience in Rwanda
This cluster-randomized waitlist-control trial evaluated Multifamily Healing Spaces (MFHS), a culturally adapted behavioral family intervention for genocide-affected communities in Rwanda.
- Conditions
- Family Relations, Psychological Trauma, Stress Disorders, Post-Traumatic, Parent-Child Relation
- Trial name
- MFHS-CRT (NCT07621705)
- Testing
- Multifamily Healing Spaces
- Where
- 5 sites in Rwanda
- Volunteers
- 319 people
- Sponsor
- Alexandros Lordos, PhD
Stress Disorders, Post-Traumatic
The Effect of EFT on Psychological States in a Veterans Population
A need exists to find fast yet effective treatment protocols for the large number of US military service personnel coming back from Iraq with post traumatic stress disorder (PTSD), and a variety of co-occurring psychological…
- Trial name
- NCT00743041
- Testing
- Emotional Freedom Techniques (EFT)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Trauma, Psychological, Psychosis
A Comprehensive Third-generation Intervention for People With Psychosis and Post-traumatic Stress Symptoms
Existing data suggest that both trauma and Post-Traumatic Stress Disorder (PTSD) are very common among individuals with psychosis.
- Trial name
- IITG-PPT (NCT05619822)
- Testing
- TAU + A comprehensive third-generation intervention, TAU
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Complutense de Madrid
Post-traumatic Stress Disorder
Exercise Training to Improve PTSD Symptoms and Health in Older Veterans
Posttraumatic stress disorder (PTSD) is prevalent among military Veterans and is more than just a psychological condition; PTSD has profound negative impacts on health, function, and quality of life.
- Trial name
- NCT04199182
- Testing
- Exercise Training, Healthy Aging Attention Control (HA-ATC)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Concerns, Post Traumatic Stress Disorder
A Comparative Effectiveness Trial of Optimal Patient-Centered Care
The nation's trauma care system, which includes trauma center hospitals \& emergency departments, is where over 30 million Americans receive care after traumatic injuries each year.
- Conditions
- Post Traumatic Concerns, Post Traumatic Stress Disorder, Depression and Suicide Ideation, Alcohol and Drug Use
- Trial name
- TSOS 5 (NCT02274688)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Washington
Cocaine Dependence, Opioid Dependence
FMRI of Stress and Addictive Disorders
The purpose of this study is to explore whether frontal brain activation in response to stress varies as a function of the presence or extent of early trauma and whether or not this effect is greater in women compared to men.
- Conditions
- Cocaine Dependence, Opioid Dependence, Alcoholism, Pathological Gamblers
- Trial name
- NCT01558973
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Posttraumatic Stress Disorder
Implementation of Evidence-based Psychotherapy for PTSD
Approximately 9% of Canadians will have Posttraumatic Stress Disorder (PTSD) in their lifetime. In the military veteran population, the lifetime prevalence of PTSD has been estimated to be as high as 20%.
- Trial name
- NCT01861769
- Testing
- Technology-enhanced Teleconsultation, Standard Teleconsultation
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Toronto Metropolitan University
Stress Disorders, Traumatic, Anxiety Disorders
Forgiveness-Based Writing to Prevent Post-Traumatic Stress Disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans
The purpose of this study is to evaluate a forgiveness-based writing intervention in an open trial with 20 Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans who have recently experienced combat-related trauma…
- Conditions
- Stress Disorders, Traumatic, Anxiety Disorders, PTSD
- Trial name
- NCT00861666
- Testing
- Forgiveness-Based Writing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- South Central VA Mental Illness Research, Education & Clinical Center
Post-traumatic Stress Disorder, Acute Stress Disorder
Feasibility Study of the Self-Care Immediate Stabilization Procedure (ISP) ® After a Traumatic Experience
The study aims to assess the feasibility of an online intervention platform based on the Immediate Stabilization Procedure (ISP®). This intervention targets early trauma reactions, aiming to reduce the risk of future PTSD.
- Trial name
- NCT06277973
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Post Traumatic Stress Disorder
Brief SEE FAR CBT Intervention Compared With Treatment as Usual for Adults With PTSD
This clinical intervention study evaluates a newly developed Brief SEE FAR CBT protocol for adults aged 18 years and older with posttraumatic stress disorder (PTSD), compared with dynamic psychotherapy treatment as usual.
- Trial name
- NCT07710573
- Testing
- Brief SEE FAR CBT Intervention, Dynamic Psychotherapy Treatment as Usual
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Community Stress Prevention Center
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Frequent Trauma-related Nightmares
Dismantling Exposure, Relaxation, and Rescripting Therapy
The purpose of this case series dismantling study is to extend previous findings regarding the efficacy of a brief treatment for chronic post-trauma nightmares by examining the dose effect and mechanism of change.
- Trial name
- ERRT (NCT02236377)
- Testing
- Exposure, Relaxation, and Rescripting Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Tulsa
Mental Disorder, Child
Association Between a Biological Pattern of Dysregulation of the HPA Axis and Mental Disorders in Children Exposed to Early Life Stress
The purpose of this study is to demonstrate an association between a biological pattern of dysregulation of the HPA axis and mental disorders in children exposed to early life stress.
- Trial name
- ESASP (NCT04363112)
- Testing
- Mini Kid II
- Where
- France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Depression, Anxiety
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
The goal is to improve mental health. The study will evaluate the impact of community-based mental health services. Successful completion of this study will contribute to the National Institute of Mental Health Strategic Plan…
- Conditions
- Depression, Anxiety, Psychological Distress, PTSD
- Trial name
- RECOUP-NY (NCT04913766)
- Testing
- Problem Management Plus, Services as Usual
- Where
- United States
- Volunteers
- 1,206 people
- Sponsor
- George Washington University
Mental Health Issue, Mental Stress
"OnCall": Implementation Study of M-Health for Canadian Public Safety Personnel
First Responders, or Public Safety Personnel (PSP), play a key role in protecting the health and safety of Canadians, yet this important work can take a toll on their mental health, leading to an elevated risk of post-traumatic…
- Conditions
- Mental Health Issue, Mental Stress, Post Traumatic Stress Disorder
- Trial name
- OnCall (NCT05255419)
- Testing
- OnCall mobile health peer support app
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- McMaster University
PTSD
Peer-led Trauma Therapy for Re-entry
The purpose of the research is to learn more about how to treat PTSD for people directly impacted by incarceration (i.e., have spent time in prison or jail).
- Trial name
- NCT06019767
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Wisconsin, Madison
PTSD
Using Heart Rate Variability Biofeedback to Improve Attention and Memory in PTSD+ Combat Veterans
This study will test the effectiveness of Heart Rate Variability (HRV) Biofeedback as a therapeutic tool in the reduction of everyday memory problems routinely experienced by combat veterans with Posttraumatic Stress Disorder…
- Trial name
- HRVB (NCT00625105)
- Testing
- Biofeedback
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- William Jennings Bryan Dorn VA Medical Center
Critical Illness
Integrated Supportive and Palliative Care for Older Adults in the ICU
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or…
- Trial name
- ProPACC (NCT04921631)
- Testing
- Early Integration of Specialty Palliative Care with Critical Care
- Where
- United States
- Volunteers
- 1,091 people
- Sponsor
- University of Pittsburgh
Coronary Artery Stenosis
FFR and Inducible Myocardial Ischemia During Adenosine Stress Testing
This is a prospective, single center study involving 150 patients with stable coronary artery disease undergoing coronary angiography for chest pain evaluation.
- Trial name
- NCT04401657
- Testing
- Fractional flow reserve with adenosine stress testing
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Asan Medical Center
Adderall, PTSD
Effects of Stimulant Medications in PTSD
While there have been advances in understanding post-traumatic stress disorder (PTSD) as a disorder and its biological features, unfortunately only one out of five traumatized persons with PTSD reach remission after cycling…
- Conditions
- Adderall, PTSD, Post Traumatic Stress Disorder
- Trial name
- SMP (NCT07664631)
- Testing
- Adderall
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago