Clinical trials: Stricture; Bowel
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Crohn Disease, Stricture; Bowel
Efficacy of Ustekinumab Therapy in Patients With Symptomatic Stricturing Crohn's Disease
This study intends to select patients with confirmed moderate-to-severe Crohn's disease (CD) and obstructive symptoms of intestinal stenosis, who have clear evidence of lumen stenosis caused by the disease itself through…
- Conditions
- Crohn Disease, Stricture; Bowel, Intestinal Stricture
- Trial name
- NCT05387031
- Testing
- Ustekinumab
- Where
- 8 sites in China
- Volunteers
- 239 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intestinal Strictures Related to Crohn´s Disease
Endoscopic Stenting in Crohn Related Strictures
Prospective, randomized-controlled trial comparing self-expandable metal stent versus ballon dialtation only for the endoscopic treatment of benign strictures related to Crohn´s disease.
- Trial name
- NCT04718493
- Testing
- Self-expandable metal stent, Balloon dilatation
- Volunteers
- 13 people
- Sponsor
- Sahlgrenska University Hospital
Crohn Disease, Stenosis
Long-term Study of Endoscopic Treatment of Stenosis in Crohn´s Disease
Stenosis is one of the most frequent complications in patients with Crohn's disease (CD), causing greater morbidity and increasing the probability of repeated surgery and short bowel syndrome.
- Trial name
- Long-ProtDilat (NCT06036680)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Mutua de Terrassa
Inflammatory Bowel Disease
Tracking the Natural Course of Silent Small Bowel Narrowing in Adults With Crohn's Disease
Crohn's disease is a long-term condition that causes inflammation in the digestive tract. Over time, some people develop narrowings in the small intestine, called "strictures." These strictures can block food and cause symptoms…
- Trial name
- SILENCE (NCT07167745)
- Where
- Serbia
- Volunteers
- 150 people
- Sponsor
- University Medical Center Zvezdara
Intracranial Artery Stenosis
Gut Microbiota and Prognostic Outcomes in Intracranial Arterial Stenosis Patients（GROW-ICAS）
GROW-ICAS (Gut microBiota and prOgnostic Outcomes in IntraCranial Arterial Stenosis) is a prospective observational cohort study that enrolls patients with intracranial arterial stenosis to investigate the correlations between…
- Trial name
- NCT07085299
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Inflammatory Bowel Diseases, Stricture; Bowel
Endoscopically Placed Lumen-Apposing Metal Stents for the Treatment of Symptomatic Intestinal Strictures in Individuals With Inflammatory Bowel Disease
This is a single-center prospective pilot study in patients with symptomatic partially obstructing intestinal strictures without severe active inflammation or penetrating complications, evaluating the use of LAMS with respect to…
- Trial name
- NCT06725563
- Testing
- Endoscopically placed lumen-apposing metal stents for the treatment of IBD-strictures
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Stenosis; Bowel, Crohn Disease
Clinical Trial to Evaluate if the Laparoscopic Administration of Cells Derived From the Fatty Tissue Can Improve the Inflammatory Stenosis in Patient With Crohn's Disease
A phase II, national, multicenter, uncontrolled and open trial to evaluate the feasibility and safety of laparoscopic administration of adipose derived allogenic mesenchymals stem cells (adMSC), for the treatment of patients with…
- Trial name
- MEIC (NCT05521672)
- Testing
- Adipose derived allogenic mesenchymal stem cells (adAMSC)
- Where
- 3 sites in Spain
- Volunteers
- 2 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease
Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic…
- Conditions
- Atherosclerotic Cardiovascular Disease, Coronary Artery Disease, Ischemic Heart Disease, Ischemic Stroke
- Trial name
- COATED-AIR (NCT06541691)
- Testing
- Enteric-coated aspirin, Plain aspirin, Hybrid strategy
- Where
- Iran
- Volunteers
- 3,000 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Crohn Disease
Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With Inflammatory Strictures Due to CD
This is an open-label, single-arm, phase 4 study to assess the safety and efficacy of mirikizumab in approximately 60 participants with stricturing CD.
- Trial name
- MIRIAD (NCT06997965)
- Testing
- Mirikizumab
- Where
- 8 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Alimentiv Inc.
Crohn Disease
Evaluation of the Efficacy and Safety of Endoscopic Dilatation and Biological Therapy in Intestinal Stenosis Due to CD
All patients with Crohn\'s disease, already undergoing biological therapy for the treatment of clinically significant intestinal stenosis and/or already undergoing endoscopic balloon dilatation during the period January 2016…
- Trial name
- NCT06603298
- Where
- Italy
- Volunteers
- 182 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Intestinal Failure, Catheter-Related Bloodstream Infection (CRBSI) Nos
Catheter Salvage in Intestinal Failure Patients
This is an observational study evaluating a catheter salvage strategy in relation to catheter-related bloodstream infections in patients with chronic intestinal failure dependent on home parenteral support.
- Trial name
- NCT03222232
- Testing
- catheter salvage
- Where
- Denmark
- Volunteers
- 715 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Colorectal Cancer, Rectal Cancer
A Prediction Model of Anastomotic Stricture After Rectal Cancer
Background: Anastomotic stricture significantly impacts patients' quality of life and long-term prognosis. However, current clinical practice lacks accurate tools for predicting anastomotic stricture.
- Conditions
- Colorectal Cancer, Rectal Cancer, Anastomotic Stenosis
- Trial name
- NCT06404554
- Testing
- without any intervention
- Where
- China
- Volunteers
- 1,542 people
- Sponsor
- Northern Jiangsu People's Hospital
Colorectal Cancer (CRC), Rectal Cancer Surgery
Indocyanine Green Fluorescence Angiography in Laparoscopic Sigmoid and Rectal Cancer Surgery
Anastomotic leakage remains a major complication after colorectal cancer surgery. Indocyanine green fluorescence angiography (ICG-FA) allows real-time intraoperative assessment of bowel perfusion; however, its clinical impact…
- Conditions
- Colorectal Cancer (CRC), Rectal Cancer Surgery, Sigmoid Colon Cancer
- Trial name
- NCT07423130
- Where
- Poland
- Volunteers
- 115 people
- Sponsor
- Jagiellonian University
Inflammatory Bowel Diseases, Crohn Disease
Stricture Definition and Treatment (STRIDENT) Observational Study.
Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Stricture; Colon
- Trial name
- STRIDENT (NCT03218202)
- Where
- Australia
- Volunteers
- 9 people
- Sponsor
- St Vincent's Hospital Melbourne
Esophageal Stricture, Duodenal Stricture
Cryoablation for Benign Gastrointestinal Anastomotic Strictures
Anastomotic stricture is a common complication following foregut surgery. The standard of care for these benign foregut anastomotic strictures is balloon dilatation.
- Conditions
- Esophageal Stricture, Duodenal Stricture, Jejunal Stricture, Anastomotic Stricture of Small Intestine
- Trial name
- NCT04372784
- Testing
- Cryotherapy, Esophagogastroduodenoscopy with Balloon Dilatation
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Southern California
Strictures Due to Crohn's Disease
A Phase 2, Placebo-Controlled Study of Oral RXC008 for Crohn's Strictures
Crohn's disease (CD) is chronic inflammatory bowel disease where any part of the Gastrointestinal (GI) tract can become inflamed and develop fibrotic strictures.
- Trial name
- ROCKETEER (NCT07832435)
- Testing
- High Dose, Low Dose
- Volunteers
- 180 people
- Sponsor
- Redx Pharma Ltd
Crohn Disease (CD)
Hybrid Endoscopic Stricturotomy Plus Balloon Dilation Versus Stricturotomy Alone for Short Crohn's Disease Strictures
Crohn's disease is a chronic condition that can lead to inflammation and narrowing (strictures) of the intestine, causing symptoms like pain, bloating, and difficulty with bowel movements.
- Trial name
- HEIST (NCT06958159)
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Urethral Stricture, Male
Small Intestinal Submucosa Graft for Repair of Anterior Urethral Strictures
The field of research for this study is tissue engineering and the utilization of a small intestinal submucosa graft as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of anterior urethral…
- Trial name
- NCT06192654
- Testing
- Small intestinal submucosa (SIS) graft urethroplasty, Autologous oral bucal mucosa graft urethroplasty
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xiaoyong Zeng
Crohn's Disease
CE-U and MRE to Predict the Efficacy of Anti-TNF Therapy in Crohn's Disease
The value of anti-TNF therapy in intestinal strictures related to Crohn's disease (CD) has not been clearly demonstrated. The results reported by some teams suggest no beneficial effect or even an increased risk of bowel…
- Trial name
- CREOLE (NCT01183403)
- Where
- 18 sites in Belgium, France
- Volunteers
- 80 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives