Clinical trials: Stricture
Chronic Kidney Disease, Pulmonary Embolism
Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease
The purpose of this study is to show that the use of low volume iso-osmolar non-ionic radio contrast medium (30 cc) in a thoracic CT Scanning procedure in a selected group of patients with chronic kidney disease (CKD) will avoid…
- Conditions
- Chronic Kidney Disease, Pulmonary Embolism, Renal Artery Stenosis, Pulmonary Cancer
- Trial name
- NCT02476526
- Testing
- Low Volume iso-osmolar non-ionic radio contrast medium, Acetylcysteine Inhalation, Sodium Bicarbonate Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
Back Pain, Spinal Stenosis
Perioperative ACT for Preventing CPSP
The present study aims to adapt and modify a brief perioperative Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use.
- Conditions
- Back Pain, Spinal Stenosis, Spondylosis, Spondylolisthesis
- Trial name
- PREPS (NCT06750874)
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Samantha Meints
Aortic Stenosis
ECG-based AI Screening for Cases of Undiagnosed Moderate-to-Severe Aortic Stenosis in the Primary Care Setting
The goal of this observational study is to learn whether AccurKardia's AK-AVS algorithm can help identify moderate-to-severe aortic stenosis (AS), a narrowing of the heart's aortic valve, in older adults who have not yet been…
- Trial name
- NCT07827105
- Testing
- AK-AVS
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- AccurKardia, Inc.
Wild-type Transthyretin Amyloidosis
Prevalence of Wild Type ATTR
Prospective, observational, single-centre, non-interventional study aiming at reporting the prevalence of ATTRwt in patients with lumbar spinal stenosis (LSS).
- Trial name
- NCT03966105
- Testing
- HE and Congo red staining
- Where
- Switzerland
- Volunteers
- 94 people
- Sponsor
- Oncology Institute of Southern Switzerland
Esophageal Neoplasms, Esophagus Stenosis
Oral Prednisolone to Prevent Esophageal Stricture After RFA for Long-segment Esophageal Neoplasia
Endoscopic radiofrequency ablation (RFA) has shown good efficacy and safety in eradicating flat-type early esophageal squamous cell neoplasia (ESCN).
- Trial name
- NCT05768282
- Testing
- Oral prednisolone (30mg/day) for 28 days
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- E-DA Hospital
Iliac Artery Stenosis, Iliac Artery Occlusion
Safety and Efficacy Study of GoldenFlow Peripheral Stent System
A Prospective, Multi-center, Single-Arm Clinical Trial to evaluate the safety and efficacy of the GodenFlow Peripheral Stent System manufactured by Lifetech Scientific (Shenzhen) Co., LTD.
- Conditions
- Iliac Artery Stenosis, Iliac Artery Occlusion, Femoral Artery Stenosis, Femoral Artery Occlusion
- Trial name
- NCT03687983
- Testing
- GoldenFlow Peripheral Stent System
- Where
- 12 sites in China
- Volunteers
- 90 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Hypertrophic Cardiomyopathy (HCM)
Precision Pharmacogenetics and Genotype Class Based Prediction of Mavacamten Response in Obstructive Hypertrophic Cardiomyopathy
This research study, aims to understand why a specific heart medication called mavacamten works better for some people with hypertrophic cardiomyopathy (HCM) than for others. We believe the answer might be in our genes.
- Trial name
- PRO-Gene Mava (NCT07408427)
- Testing
- Observational study, no new intervention offered
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Manchester
Other Specified Diseases of Biliary Tract
Comparison of the Guide-wire G-240 to a Combination of a Flexible/Hydrophil and a Nitinol Guide Wire
In ERCP practice, most often a combined use of guidewires is necessary to attain a therapeutic aim. E.g. a hyperflexible hydrophilic guidewire is changed after cannulating a stricture to a nitinol wire for improved stability with…
- Trial name
- NCT01382680
- Testing
- Guidewire
- Where
- Germany
- Volunteers
- 222 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Aortic Stenosis
CAN3T - Canadian TAVI Triage Tool
The goal of this trial is to see if a tool that may reduce wait times will reduce bad outcomes in participants on the TAVI waitlist.
- Trial name
- CAN3T (NCT06551610)
- Testing
- Triage Tool
- Volunteers
- 5,060 people
- Sponsor
- Sunnybrook Health Sciences Centre
Intracranial Atherosclerosis
An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Stenosis
The IRISS study is designed to collect clinical and angiographic outcomes data when stenting intracranial atherosclerotic lesions using the Wingspan™ Stent System with Gateway™ PTA Balloon Catheter in routine clinical practice.
- Trial name
- IRISS (NCT00929383)
- Testing
- Wingspan Stent System with Gateway PTA Balloon Catheter
- Where
- 19 sites in France, Germany
- Volunteers
- 82 people
- Sponsor
- Stryker Neurovascular
Degeneration, Spondylosis
Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Fusions
Introduction: Degenerative changes of the discs and facet joints in the lumbar spine can result in pain and disability from spondylosis, spondylolisthesis and stenosis.
- Conditions
- Degeneration, Spondylosis, Spondylolithesis, Stenosis
- Trial name
- Aegis (NCT00555659)
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Columbia Orthopaedic Group, LLP
Stroke Patients With Symptomatic Intracranial Atherosclerotic Stenosis
Evolocumab Added to Statin Therapy in Symptomatic Intracranial Atherosclerotic Stenosis (EAST-ICAS)
The primary goal of the trial is to investigate whether the experimental arms (receiving the Proprotein Convertase Subtilisin-Kexin Type 9 [PCSK9] inhibitor Evolocumab plus statin) could cause more changes from baseline in…
- Trial name
- EAST-ICAS (NCT05741086)
- Testing
- Evolocumab, Atorvastatin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Aortic Stenosis, Mitral Regurgitation
Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation
Aortic stenosis is a condition in which the aortic valve becomes narrow and does not open properly, making it harder for the heart to pump blood to the body.
- Conditions
- Aortic Stenosis, Mitral Regurgitation, Tricuspid Regurgitation, Transcatheter Aortic Valve Implantation (TAVI)
- Trial name
- MASTER-TAVI II (NCT07623083)
- Volunteers
- 300 people
- Sponsor
- Josep Rodes-Cabau
Antiphospholipid Syndrome, Stenosis
Prevalence and Etiologies of Intracranial Stenosis in Patients With Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) is an important cause of young stroke which could result in major disability. Cohort studies suggested that 17% of young ischemic stroke were accountable by APS (1).
- Conditions
- Antiphospholipid Syndrome, Stenosis, Intracranial Stenosis
- Trial name
- ICAS_APS (NCT05583305)
- Testing
- Imaging assessment, Neurosonology assessment, Blood Test
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Aortic Stenosis With Bicuspid Valve
Circle Method Observational Project - Non-interventional, Retrospective, Multicenter Data Collection
The goal of this non-interventional, retrospective data analysis is to validate the circle method for patients with bicuspid aortic heart valves undergoing transcatheter aortic heart valve implantation (TAVI).
- Trial name
- NCT05844969
- Where
- 4 sites in United Kingdom
- Volunteers
- 140 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Stenosis, Restenosis
Clinical Trial on Peripheral Arteries Treated With SeQuent® Please P Paclitaxel Coated Balloon Catheter
The aim of the study is to assess the safety and efficacy of the paclitaxelreleasing balloon catheter SeQuent® Please P to treat de novo and restenotic lesions in the superficial femoral artery and the proximal two segments of…
- Trial name
- ConSeQuent (NCT01970579)
- Testing
- Paclitaxel coated balloon, uncoated PTA catheter
- Where
- 7 sites in Germany
- Volunteers
- 153 people
- Sponsor
- B. Braun Melsungen AG
Coronary Artery Disease
Mainz Registry of Flow-mediated Constriction
The goal of the flow-mediated constriction/ FMC-registry is to investigate whether the measurement of endothelial function using flow-mediated dilation and flow-mediated constriction provides on the presence of coronary…
- Trial name
- NCT01787370
- Where
- Germany
- Volunteers
- 750 people
- Sponsor
- Johannes Gutenberg University Mainz
Aortic Stenosis
Feasibility And Safety of Early Discharge After Transfemoral Transcatheter Aortic Valve Implantation
The hypothesis behind this study is that there is a proportion of patients considered high or intermediate risk for surgery, but relatively low risk for TAVI, which can be discharged early after the procedure (within the first…
- Trial name
- FAST-TAVI (NCT02404467)
- Testing
- TF TAVI
- Where
- 10 sites in Italy, Netherlands and 1 more
- Volunteers
- 502 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
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