Clinical trials: Stricture
Aortic Stenosis
A Clinical Trial of the Transcatheter Aortic Valve Implantation System With a Prospective, Multi-Center, One-Arm Approach to Evaluate the Efficacy and Safety in the Treatment of Patients With Severe Aortic Stenosis
A Clinical Trial of the Transcatheter Aortic Valve Implantation System with a Prospective, Multi-Center, One-Arm Approach to Evaluate the Efficacy and Safety in the Treatment of Patients with Severe Aortic Stenosis
- Trial name
- NCT05673525
- Testing
- Transcatheter Aortic Valve Implantation (KOKA-VALVE)
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Coronary Disease, Heart Diseases
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- PIV-EPIC (NCT06535568)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Central Venous Catheter, Catheter-Related Bloodstream Infection (CRBSI) Nos
Access in Dialysis for Better Outcomes in Patient Therapy
This is a prospective, multi-center health economic study in Canada. Participants will be randomly assigned to receive either the study or control dialysis catheter.
- Trial name
- ADOPT (NCT03109574)
- Testing
- BioFlo DuraMax Chronic Hemodialysis Catheter, Standard of Care Catheter
- Where
- 3 sites in Canada
- Volunteers
- 92 people
- Sponsor
- William Osler Health System
Atrial Fibrillation, Valve Heart Disease
Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease
The prevalence of AF, which is tachyarrhythmia, is approximately 2% of the entire population and 5% of the population at the age of 60 or older.
- Trial name
- DECISIVE (NCT02982850)
- Testing
- Dabigatran, Acetylsalicylic acid, Warfarin
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Asan Medical Center
Cholangiocarcinoma, Hilar, Biliary Stricture
Endoscopic Scissors Cutting Nasobiliary Duct VS Bilateral Plastic Stent
The purpose of this study is to explore the efficacy and safety of endoscopic scissors cutting nasobiliary ducts in the treatment of malignant hilar biliary tract stenosis
- Conditions
- Cholangiocarcinoma, Hilar, Biliary Stricture, Hilar Cholangiocarcinoma, Klatskin Tumor
- Trial name
- NCT06106750
- Testing
- Endoscopic nasobiliary duct cutting, Bilateral plastic stent
- Where
- China
- Volunteers
- 122 people
- Sponsor
- First People's Hospital of Hangzhou
Stroke, Carotid Stenosis
Spider Versus Emboshield Distal Protection on Cerebral Microembolization During Vulnerable Plaque in Carotid Artery Stenting
A single center, prospective, outcome-assessor-blinded, randomized controlled trial study (CASH-ES) is designed to compare the efficiency of two different distal embolism protection devices (SpiderFX and Emboshield NAV6) in…
- Conditions
- Stroke, Carotid Stenosis, Carotid Artery Stent
- Trial name
- CASH-ES (NCT04904250)
- Testing
- Emboshield, Spider
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Xuanwu Hospital, Beijing
Abdominal Aortic Aneurysm, Abdominal Aortic Stenosis
Effectiveness of TAP (Transversus Abdominis Plane) Block for Abdominal Aortic Surgery
The goal of this study is to learn about the effectiveness of TAP block for pain relief after vascular surgery on the abdominal aorta.
- Conditions
- Abdominal Aortic Aneurysm, Abdominal Aortic Stenosis, Syndrome, Leriche
- Trial name
- NCT05860452
- Testing
- ropivacaine, normal saline
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Aortic Stenosis
A Comparison of Advanced Imaging Techniques in Aortic Stenosis
In patients with aortic stenosis the valve through which blood is pumped out of the main heart chamber is narrowed. This results in heart muscle working harder to open the valve so blood can circulate around the body.
- Trial name
- AIm-AS (NCT01775215)
- Testing
- Cardiac I123-MIBG Scintigraphy, Cardiac MRI, Stress and rest Echocardiogram
- Where
- United Kingdom
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Aortic Stenosis
A Study of Transcatheter Aortic Valve Replacement Case Selection and Valve Sizing Using the ABC Bicuspid Sizing Algorithm
The goal of this study is to learn what effects the ABC Bicuspid Sizing Algorithm has on the clinical outcomes of patients with bicuspid aortic stenosis after having a transcatheter aortic valve replacement (TAVR) using the…
- Trial name
- NCT06991517
- Testing
- The ABC Bicuspid Sizing Algorithm
- Where
- 20 sites in Australia, Canada and 6 more
- Volunteers
- 290 people
- Sponsor
- World Health Research Inc.
Cervical Intervertebral Disc Disease, Cervical Spinal Stenosis
Prospective Observation of the Fluoroscopy-guided Cervical Epidural Approach Using the Contralateral Oblique View
The aim of the present study is to investigate the safety and clinical utility of contralateral oblique view for fluoroscopic guided cervical epidural access.
- Conditions
- Cervical Intervertebral Disc Disease, Cervical Spinal Stenosis, Cervical Radicular Pain, Herpes Zoster
- Trial name
- NCT04774458
- Testing
- Fluoroscopic-guided cervical epidural access
- Where
- South Korea
- Volunteers
- 439 people
- Sponsor
- Asan Medical Center
Carotid Artery Stenosis
Time to Post-Anesthesia Neurological Evaluation With Three Different Anesthetic Techniques
The objective of this pilot study is to analyze the differences in time to first postoperative neurological examination (cranial nerve XII - tongue movement, movement of extremities) and intraoperative hemodynamic stability with…
- Trial name
- NCT03996148
- Testing
- Remifentanil, Propofol, and Desflurane, Remifentanil, Dexmedetomidine, and Desflurane, Remifentanil and Desflurane
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Cooper Health System
Disc Degenerative Disease, Spondylolisthesis
A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery
The primary objective of this study is to demonstrate that the efficacy and safety of Spine fusion system manufactured in China is no inferior than imported product.
- Conditions
- Disc Degenerative Disease, Spondylolisthesis, Spinal Fracture, Spinal Deformity
- Trial name
- NCT02252185
- Testing
- Johnson&Johnson Medical Suzhou made Spine Fusion System, Imported EXPEDIUM screws and OPAL cage
- Where
- 8 sites in China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Esophagectomy
Prediction of Anastomotic Leak/Stricture After Esophagectomy With Gastric Pull-up by Venous Blood Gas
Esophageal resection becomes a routine surgical procedure in many medical centers. Usually reconstruction after esophagectomy is achieved by gastric pull-up with cervical or intrathoracic anastomosis.
- Trial name
- NCT02546687
- Testing
- Venous blood sampling
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Symptomatic Severe Aortic Stenosis
PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - S3 Intermediate
The purpose of this trial is to determine the safety and effectiveness of the Edwards SAPIEN 3 transcatheter heart valve and delivery systems which are intended for use in patients with symptomatic, calcific, and severe aortic…
- Trial name
- PII S3i (NCT03222128)
- Testing
- TAVR
- Where
- 51 sites in United States
- Volunteers
- 1,074 people
- Sponsor
- Edwards Lifesciences
Ureteral Stricture, Hydronephrosis
Application of the Sentire C1000 for Ureteral Stricture Repair
The purpose of this clinical study is to evaluate the safety and efficacy of the Sten® Laparoendoscopic Surgical System C1000 for benign ureteral reconstruction surgery.
- Trial name
- ROBUST-C1000 (NCT06983067)
- Testing
- Cornerstone C1000 Robotic Surgery System
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuesong Li
Aortic Coarctation, Cardiomyopathy
Radiation-Free Heart Catheterization Using MRI
Currently catheters used in heart catheterization procedures are guided throughout the heart chambers and blood vessels by pictures taken by x-rays. This technology exposes patients to radiation.
- Conditions
- Aortic Coarctation, Cardiomyopathy, Atrial Septal Defect, Aortic Stenosis
- Trial name
- NCT02739087
- Testing
- MRI guided cardiac catheterization, Magnetic resonance imaging
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Joshua Kanter
Tracheal Stenosis
Observational Study for the Evaluation of Tracheal Stenosis in COVID-19 Patients
Define the actual incidence of tracheal stenosis in patients who underwent either prolonged intubation or tracheostomy and to compare incidence, clinical course and outcome between COVID-19 and non-COVID-19 patients.
- Trial name
- TS1 (NCT04686721)
- Testing
- Chest CT scan + baseline spirometry
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Total Anomalous Pulmonary Venous Connection, Pulmonary Venous Stenosis
Sutureless Closure for Primary Total Anomalous Pulmonary Venous Connection
The purpose of this study is to assess the percentage of pulmonary venous stenosis after TAPVC repair with sutureless closure.
- Conditions
- Total Anomalous Pulmonary Venous Connection, Pulmonary Venous Stenosis, Sutureless Closure
- Trial name
- TAPVC (NCT04938921)
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Children's Hospital 1
Carotid Artery Stenosis
Long-term Neurocognitive Sequelae of Subclinical Microembolization During Carotid Interventions
Microembolization is commonly associated with carotid artery stenting (CAS), but our understanding of subclinical microembolization is superficial.
- Trial name
- NCT01718600
- Testing
- Neuropsychological testing
- Where
- 3 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypertrophic Cardiomyopathy
A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy
Study population: 1) mutation carriers without the hypertrophic phenotype (pre-clinical Hypertrophic Cardiomyopathy (HCM)) and in 2) patients with clinically overt HCM (clinical HCM).
- Trial name
- BE STRONG HCM (NCT01559714)
- Where
- Netherlands
- Volunteers
- 81 people
- Sponsor
- Heartcenter, University Medical Center St. Radboud
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