Clinical trials: Stricture
Intracranial Atherosclerosis, Stent Stenosis
Elucidate Outcomes of Elective High-grade/Total Occlusion Intracranial Arteries Using Low-profile Self-expanding Stent
Intracranial atherosclerotic disease (ICAD) is a high prevalent cause of stroke, especially in Asian population and can be categorized as either symptomatic (resulting in acute ischemic stroke) or asymptomatic.
- Conditions
- Intracranial Atherosclerosis, Stent Stenosis, Ischemic Stroke
- Trial name
- NCT05947994
- Testing
- Intracranial stenting with Credo® stent
- Where
- Vietnam
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Ischemic Heart Disease, Coronary Artery Stenosis
Trial to Assess the Everolimus-Eluting Coronary Stent System (PROMUS Element) for Coronary Revascularization
The PROMUS Element™ clinical trial (PLATINUM-PLUS) consists of a randomized controlled trial (RCT) in the European Union (EU) which will enroll approximately 2980 subjects (2:1 randomization PROMUS Element™: Xience™ Prime) in a…
- Trial name
- PLATINUM+ (NCT01342822)
- Testing
- Angioplasty (PROMUS Element™, and Xience™ Prime stent)
- Where
- 50 sites in France, Germany and 6 more
- Volunteers
- 2,980 people
- Sponsor
- European Cardiovascular Research Center
Fragile X Syndrome, Williams Syndrome
Cooperative Parent Mediated Therapy in Children With Fragile X Syndrome and Williams Syndrome
Fragile X Syndrome (FXS) and Williams-Beuren Syndrome (WBS) are relatively rare disorders characterized by developmental delay associated to socio-communicative deficit and autistic-like behaviours.
- Trial name
- NCT04610424
- Testing
- Cooperative Parent Mediated Therapy" (CPMT), As usual
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Aortic Valve Stenosis
Exercise-based Cardiac Rehabilitation in Patients With Aortic Stenosis After Transcatheter Aortic Valve Implantation
Aortic valve stenosis (AS) is the most common valve disease among older individuals. In symptomatic AS, mortality is high, and the only treatment that improves prognosis and survival is transcatheter aortic valve implantation…
- Trial name
- TAVI (NCT06283940)
- Testing
- Physiotherapist-led exercise based cardiac rehabilitation (PT-X)
- Where
- Sweden
- Volunteers
- 135 people
- Sponsor
- Vastra Gotaland Region
Esophageal Stricture
Balloon Dilation Methods for Benign Esophageal Stricture
This is the first head to head, prospective, randomized, double-blind clinical trial comparing two different approaches of balloon dilation (standard versus progressive dilation) for benign esophageal strictures.
- Trial name
- NCT04730076
- Testing
- Standard Balloon Dilation, Progressive Balloon Dilation
- Where
- United States
- Sponsor
- Samuel H Mardini
Hypertrophic Cardiomyopathy (HCM), Obstructive HCM (oHCM)
Aom0304 in Adult Patients With Symptomatic Hypertrophic Cardiomyopathy
The goal of this clinical trial is designed to characterise the safety, tolerability, efficacy, and PK of Aom0304 across oHCM and nHCM populations and to inform dose selection for future Phase 3 development.
- Conditions
- Hypertrophic Cardiomyopathy (HCM), Obstructive HCM (oHCM), Non-obstructive HCM (nHCM)
- Trial name
- NCT07675668
- Testing
- QG101-23-0 enteric coated capsule (60/120/240/360 mg BID), QG101-23-0 enteric coated capsule (120/240/360/480mg BID)
- Volunteers
- 56 people
- Sponsor
- Amckaus PTY LTD.
Generalized Visual Field Contraction or Constriction
A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph
The study is aimed to develop a new reaction-time based method for examining the visual field and to study the effect of refractive error on the magnification of a fundus photograph in order to evaluate the true size of a retinal…
- Trial name
- NCT01843582
- Where
- Finland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Hypertrophic Cardiomyopathy
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem
This is a pilot clinical trial to assess whether the administration of diltiazem may be able to decrease the development or progression of hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00319982
- Testing
- Diltiazem
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Brigham and Women's Hospital
Aortic Valve Stenosis
Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics
Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously.
- Trial name
- NCT01118442
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Arterial Occlusive Disease, Intermittent Claudication
ATHERO: Advanced Technology Halting Early Re-Stenosis and Occlusion
The rise of minimal access surgery has heralded the approval of a number of endovascular devices with similar indications. This is particularly true for the treatment of lower extremity ischemia.
- Trial name
- NCT00407940
- Testing
- Lower extremity Atherectomy and Cryoplasty
- Where
- United States
- Sponsor
- University of California, San Diego
Stroke, Carotid Stenosis
PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
Ischaemic stroke is a major cause of death and disability worldwide. In patients with recent stroke, the 18F-fluoride positron emission tomography-computed tomography highlights high-risk culprit carotid plaque and is more…
- Trial name
- NCT03215550
- Testing
- CEA, 18F PET-MRI, Transcranial Doppler
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Stenosis of Arteriovenous Dialysis Fistula
SUPER-DIALYSIS-Study: Supera Stent Interventions in Juxta-anastomotic (re)Stenosis
The purpose of this exploratory study is to evaluate safety and effectiveness of treatment of juxta-anastomotic (re)stenosis with SUPERA stent by improving hemodynamic situation through obtuse shaping of the anastomosis.
- Trial name
- NCT05232760
- Testing
- Supera™ Peripheral Stent System
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Klinikum Arnsberg
Severe Native Calcific Aortic Stenosis, Symptomatic Heart Disease Due to Severe Native Calcific Aortic Stenosis
Validation Of anatomY-specific Aortic Valve Implantation Guided by Software Using EncantoR
VOYAGER CE Clinical Study using the Encantor TAVI System.
- Trial name
- VOYAGER CE (NCT07696182)
- Testing
- Prospective, single-arm, multi-center study.
- Volunteers
- 150 people
- Sponsor
- Abbott Medical Devices
Aortic Valve Stenosis, Aortic Valve Insufficiency
Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry
In the past years a substantial shift away from mechanical heart valves occurred and bioprosthetic heart valves claimed majority of market shares irrespective of patients' age.This indicates that population with failed surgical…
- Conditions
- Aortic Valve Stenosis, Aortic Valve Insufficiency, Ventricular Outflow Obstruction, Left
- Trial name
- NCT03361046
- Testing
- Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI)
- Where
- 12 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Warsaw
Cognitive Manifestations
Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
Carotid artery plaques are known to cause stroke. Cognitive impairment is an insidious but poorly understood problem in patients with carotid plaques.
- Trial name
- ACCOF (NCT01353196)
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Biliary Stricture
Optical Frequency Domain Imaging (OFDI) for Biliary Stricture Imaging
The goal of this study is to evaluate the potential of comprehensive biliary Optical Frequency Domain Imaging (OFDI) for assessing common bile duct or common hepatic duct strictures, determining cholangiocarcinoma margins, and…
- Trial name
- NCT01439620
- Testing
- MGH Optical Frequency Domain Imaging (OFDI)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Renovascular
Drug-eluting Balloon for Treatment of Non-atherosclerotic Renal Artery Stenosis
Efficacy of drug eluting balloon(DEB) for non-atherosclerotic renal artery stenosis will be tested in this study. The intervention group will be treated with paclitaxel eluting balloon.
- Trial name
- NCT04366596
- Testing
- Angioplasty with paclitaxel eluting balloon, Angioplasty with plain old balloon
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Aortic Valve Stenosis
Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II
Current care randomized clinical trial comparing the CE marked Symetis ACURATE neo™ Aortic Bioprosthesis and ACURATE TF™ Transfemoral Delivery System with the CE marked Medtronic CoreValve Evolut R TAVI system (or any future…
- Trial name
- SCOPE II (NCT03192813)
- Testing
- Symetis ACURATE neo™ transfemoral TAVI system, Medtronic CoreValve Evolut R TAVI System
- Where
- 23 sites in Denmark, France and 4 more
- Volunteers
- 796 people
- Sponsor
- Ceric Sàrl
Spinal Stenosis
Retrospective Evaluation of Performance of Coflex® Interlaminer Technology Versus Decompression With or Without Fusion
To evaluate clinical, radiologic and patient-reported outcomes who have been treated 1 or 2 levels with the coflex® Interlaminar Technology or decompression with or without fusion.
- Trial name
- NCT03041896
- Testing
- coflex® Interlaminar Technology
- Volunteers
- 5,050 people
- Sponsor
- Paradigm Spine
Carotid Artery Disease, Carotid Stenosis
Adapt Monorail Carotid Stent System: A Postmarket Clinical Follow-up Study
The purpose of this study is to get outcomes data for the Adapt Monorail Carotid System used in conjunction with the FilterWire Embolic protection system for treatment of patients that suffer from carotid artery stenosis and that…
- Conditions
- Carotid Artery Disease, Carotid Stenosis, Stroke
- Trial name
- ASTI (NCT01133327)
- Testing
- Carotid Artery Stenting
- Where
- 11 sites in Belgium, Germany and 1 more
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation
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