Clinical trials: Stroke, Acute, Ischemic
Stroke, Ischemic, Stroke, Acute
Comparison Between Unihemispheric and Bihemispheric TCDS in Subacute Ischemic Stroke Patients
This is a randomized clinical trial to study the effect of tDCS in participants with subacute ischemic stroke, the study participants will be randomly assigned into three groups; bihemispheric, unihemispheric and sham group.
- Conditions
- Stroke, Ischemic, Stroke, Acute, Stroke, Lacunar, Hemiparesis
- Trial name
- NCT04770363
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Alexandria University
Ischaemic Stroke
Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis
The aim of this study is to assess the efficacy and safety of minocycline in improving functional outcome among patients with acute ischaemic stroke receiving intravenous thrombolysis.
- Trial name
- EMPHASIS-2 (NCT07526987)
- Testing
- Minocycline Hydrochloride Capsule (50 mg per capsule)
- Where
- 3 sites in China
- Volunteers
- 934 people
- Sponsor
- Beijing Tiantan Hospital
Myocardial Infarction, Acute Disease
Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction
This project aims to assess the ability of cardiac imaging (cardiac MRI and Doppler-echocardiography) post-processing tools to predict a combined end-point of intraventricular thrombosis, silent brain infarcts, clinical stroke…
- Conditions
- Myocardial Infarction, Acute Disease, Thrombosis, Heart Diseases
- Trial name
- ISBITAMI (NCT02917213)
- Testing
- Doppler echocardiogram exam, Carotid duplex ultrasound exam, Cardiac MRI
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Ischemic Stroke, Thrombectomy
IMMunological resPonse Assessment afteR Acute iSchemic Stroke Treated With Endovascular Therapy (IMPRESS)
IMPRESS study aims to describe the immuno-inflammatory and thrombo-inflammatory profiles during the first 24/36 hours of treatment of patients suffering from AIC treated with TM, and to study the possible impact of these profiles…
- Trial name
- IMPRESS (NCT04663399)
- Testing
- Prospective patient
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Stroke
Reduce Inefficiencies in Management of Spasticity
The purpose of this study is to evaluate the effectiveness of a spasticity screener and to determine if the spasticity screener results are useful to healthcare providers and impact clinical decision making
- Trial name
- ReIMage (NCT07639632)
- Testing
- Screener, Standard of care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Ischemic Stroke
Prognostic Markers of Post-Stroke Depression (PROMoSD)
Single-center prospective observational study investigating the association of brainstem raphe hypoechogenicity detected by transcranial sonography and post-stroke depression three months after an acute ischemic stroke.
- Trial name
- PROMoSD (NCT05580198)
- Testing
- Transcranial sonography.
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Acute Ischemic Stroke Patients
Low-Dose Tenecteplase for Acute Ischemic Stroke Treatment in Aging Patients
The DATE-AGING study is a prospective, multicenter, randomized controlled trial investigating low-dose tenecteplase in elderly patients with acute ischemic stroke.
- Trial name
- DATE-AGING (NCT07294209)
- Testing
- low-dose tenecteplase intravenous thrombolysis, standard-dose tenecteplase intravenous thrombolysis
- Where
- 51 sites in China
- Volunteers
- 806 people
- Sponsor
- Southwest Hospital, China
Acute Ischemic Stroke
A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke
The study is a prospective, multicenter, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of tirofiban in combination with intravenous thrombolytic therapy with alteplase in acute ischemic…
- Trial name
- RESET (NCT05188417)
- Testing
- Tirofiban 0.05 MG/ML, 0.9% sodium chloride solution
- Where
- China
- Volunteers
- 266 people
- Sponsor
- GrandPharma (China) Co., Ltd.
Ischemic Stroke, Atrial Fibrillation
TIMING of Oral Anticoagulant Therapy in Acute Ischemic Stroke With Atrial Fibrillation
This study will compare early with late start of treatment with Non-vitamin K oral anticoagulation (NOAC) in adult patients with acute ischemic stroke and atrial fibrillation; it is a registry-based randomized clinical trial…
- Trial name
- NCT02961348
- Testing
- Early start of NOAC, Late start of NOAC
- Where
- 36 sites in Sweden
- Volunteers
- 888 people
- Sponsor
- Uppsala University
Acute Ischemic Stroke
Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke
The purpose of this prospective randomized controlled trial was to compare intensive insulin therapy with a carbohydrate restrictive strategy in patients with acute ischemic stroke evaluating the outcome through the Glasgow…
- Trial name
- NCT00747279
- Testing
- Carbohydrate restrictive strategy, Intensive insulin therapy
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Hospital Sao Domingos
Stroke, Ischemic, Stroke, Acute
Ischemic Strokes While on NOAC - How Compliance Matters
This study is aimed to depict the epidemiological trend, aetiologies, clinical characteristics, treatment options of IS-NOAC in face of the rapidly increasing NOAC usage.
- Conditions
- Stroke, Ischemic, Stroke, Acute, Stroke Syndrome, Stroke, Cardiovascular
- Trial name
- NCT04607070
- Where
- Hong Kong
- Volunteers
- 91 people
- Sponsor
- Chinese University of Hong Kong
Acute Ischemic Stroke
Predictive Role of sTREM in Endovascular Thrombectomy Outcomes
Soluble triggering receptor expressed on myeloid cells (sTREM), which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation.
- Trial name
- NCT06545591
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Arterial Ischemic Stroke
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
The primary study objective is to assess the safety of afamelanotide while the secondary objective is to assess whether the therapy affects the size of the penumbra, by increasing blood flow, restoring oxygen supply to the brain…
- Trial name
- NCT04962503
- Testing
- Afamelanotide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Ischemic Stroke, Hyperglycemia
Procoagulant Effects of Hyperglycemia After Acute Stroke: A Pilot Study
Between twenty and fifty percent of people who have acute stroke have hyperglycemia (high blood sugar) with it. The purpose of this study is to examine the relationships between diabetes mellitus, hyperglycemia,whole blood tissue…
- Trial name
- NCT00373269
- Volunteers
- 21 people
- Sponsor
- Temple University
Acute Ischemic Stroke
Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study designed to evaluate the efficacy of recombinant human tissue-type plasminogen activator variant (rhTNK-tPA) (0.25 mg/kg, maximum dose…
- Trial name
- TRACE-LATE (NCT07201688)
- Testing
- rhTNK-tPA
- Where
- China
- Volunteers
- 890 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Ischemic Stroke, Depression
Dose Milnacipran Prevent Depressive Symptoms in Patients With Acute Stroke?
Depression is one of the important psychiatric sequelae after stroke. The prevalence of post stroke depression (PSD) is approximately 20-40%.
- Trial name
- NCT00606203
- Testing
- milnacipran
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Acute, Acute Ischemic Stroke
Early Rehab With VR for First-time Acute Stroke
The goal of this clinical trial is to confirm the efficacy and feasibility of early rehabilitation combined with virtual reality training in patients following first-time acute stroke.
- Trial name
- NCT05929742
- Testing
- virtual reality training, early rehabilitation
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- National Defense Medical Center, Taiwan
Ischemic Stroke
European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke
Prospective, single-arm, multicenter, observational registry of the ACE Reperfusion Catheters and the Penumbra System in Europe.
- Trial name
- PROMISE (NCT02678169)
- Testing
- Penumbra Aspiration System
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- Penumbra Inc.
Acute Ischemic Stroke AIS
Exploration of the Efficacy and Mechanism of Galantamine (an Extract From Lycoris Aurea) in Treating Ischemic Stroke
Although mechanical thrombectomy or thrombolytic therapy for large vessels can achieve a revascularization rate (TICI ≥2b) of over 90%, 30-50% of patients still exhibit poor functional outcomes.
- Trial name
- NCT07003386
- Testing
- Galantamine, Standard treatment for acute ischemic stroke
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital