Clinical trials: Stroke, Acute, Ischemic
Middle Cerebral Artery Acute Ischemic Stroke
Predictive Multimodal MRI Factors in Subacute Cerebral Artery Occlusiontreated by Thrombectomy (PIMISUTT)
Our study aims to measure metabolic and functional parameters of the infarcted territory by multimodal cerebral MRI in patients diagnosed with unilateral proximal occlusion of the middle cerebral artery and treated by…
- Trial name
- PIMISUTT (NCT04651010)
- Testing
- Multimodal MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Acute Ischemic Stroke (AIS), Acute Ischemic Stroke From Large Vessel Occlusion
Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke
Since 2015, many randomized trials have shown that endovascular thrombectomy improve functional outcomes in acute ischemic stroke patients with large vessel occlusion.
- Trial name
- XL-STROKE (NCT06210633)
- Testing
- medical management, endovascular thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhongming Qiu
Stroke, Acute, Hypoxia-Ischemia, Brain
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome
The overall incidence of good outcome for AIS following endovascular treatment is only proximately 50%. Whether NBO was safe and effective to improve acute ischemic stroke prognosis is still unclear.
- Conditions
- Stroke, Acute, Hypoxia-Ischemia, Brain, ENDOVASCULAR TREATMENT
- Trial name
- NBOL (NCT05039697)
- Testing
- oxygen
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Capital Medical University
Acute Stroke, Transient Ischemic Attack
3 Tesla (3T) Stroke Medical Radiologic Technology (MRT) for Examining Mismatch in 1000+
The purpose of this study is to compare clinical and economic parameters of stroke patients who have received acute MRI imaging (test group) to patients who have received routine CT imaging (control group) in the clinical setting…
- Trial name
- 1000Plus (NCT00715533)
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Ischemic, Cerebrovascular Accident
Effects of High-intensity Interval Aerobic Training on Balance, Walking Capacity, and Quality of Life in Patients With Sub-acute Stroke
Hemiplegia is one of the most common sequelae of stroke. Stroke is the leading cause of disability in adults all around the world.
- Trial name
- NCT04835740
- Testing
- High intensity Interval Training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Akhtar Saeed Medical and Dental College
TIA, Stroke
Evaluation of the HARM for the Detection of a Cerebral Ischemia in TIA/TNA Patients
The research project investigates the incidence of the hyperintense acute reperfusion marker (HARM) in patients with transient ischemic attack (TIA) or transient neurological attack (TNA).
- Conditions
- TIA, Stroke, Ischemia, Diagnoses Disease
- Trial name
- NCT03555643
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Universitätsmedizin Mannheim
Stroke, Ischemic
Butyphthalide in Combination With Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke
Acute ischemic stroke (AIS) is the most common type of stroke, which has high rate of morbidity, mortality and disability. A large number of studies have confirmed that the thrombolytic therapy can effectively open blood vessels…
- Trial name
- NCT03394950
- Testing
- Butyphthalide combined with rtPA, rtPA
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hui-Sheng Chen
Ischemic Stroke, Acute
MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure
The use of metabolic modulators creates prospects for increasing the efficiency of the rehabilitation treatment of patients with acute cerebral failure
- Trial name
- NCT06221826
- Testing
- Mexidol
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Pharmasoft
Acute Ischemic Stroke
The Screening of Neuroprotective Biomarkers After Acute Ischemic Stroke
Neuroprotection is expected to be an important therapeutic strategy for acute ischemic stroke(AIS), but almost all neuroprotective drugs proved effective in rodent models have failed after entering clinical trials.
- Trial name
- NCT05689528
- Where
- China
- Volunteers
- 453 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Ischemic Stroke
Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL-2)
This phase 2, multicenter, randomized, double-blind, placebo-controlled trial will evaluate the efficacy and safety of anisodine hydrobromide in patients with acute ischemic stroke undergoing endovascular thrombectomy.
- Trial name
- NCT07800572
- Testing
- Anisodine Hydrobromide
- Where
- 13 sites in China
- Volunteers
- 204 people
- Sponsor
- Capital Medical University
Stroke, Ischemic
Sensory Versus Motor Level Neuromuscular Electrical Stimulation
Dysphagia is a serious cause of morbidity and mortality in stroke survivors. Electrical stimulation is often included as part of the treatment plan for dysphagia, and can be applied at a sensory or motor level intensity.
- Trial name
- NMES (NCT05102877)
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Acute Ischemic Stroke, Ischemic Stroke
Clinical Trial to Evaluate the Safety of Continuous IV Tirofiban in Acute Ischemic Stroke
We will recruit men and non-pregnant women of any ethnic background between the age ≥ 18 and ≤ 90 years that have acute ischemic stroke and underwent Mechanical Thrombectomy (MT) with TICI 2b or 2b following MT.
- Trial name
- iTREMT (NCT04818944)
- Testing
- Tirofiban Hydrochloride
- Where
- United States
- Sponsor
- University of Iowa
Ischemic Stroke, TIA
Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute…
- Trial name
- NCT05439356
- Testing
- Colchicine
- Where
- 244 sites in China
- Volunteers
- 8,343 people
- Sponsor
- Beijing Tiantan Hospital
Brain Diseases, Cardiovascular Diseases
pRESET for Occlusive Stroke Treatment
Compare the safety and effectiveness of pRESET to Solitaire in the treatment of stroke related to large vessel occlusion
- Conditions
- Brain Diseases, Cardiovascular Diseases, Central Nervous System Diseases, Cerebrovascular Disorders
- Trial name
- PROST (NCT03994822)
- Testing
- Mechanical Thrombectomy using the pRESET Thrombectomy device, Mechanical Thrombectomy using the Solitaire Revascularization Device
- Where
- 24 sites in United States, Germany
- Volunteers
- 340 people
- Sponsor
- phenox Inc.
Stroke
Validation of an Electroencephalograph Based Algorithm for Detection of Onset and Deterioration of Acute Ischemic Stroke by Comparison to NIHSS
The purpose of this study is the validation of an Electroencephalograph based algorithm for detection of onset and deterioration of Acute Ischemic Stroke by Comparison to NIHSS.
- Trial name
- NCT01738412
- Testing
- Neurokeeper stroke detector
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Neurokeeper Technologies
Stroke, Large Ischemic Core
Assessing Local Hypothermia and Endovascular Recanalization for Acute Stroke With a Large Core Infarction
A multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial to assess the effectiveness and safety of catheter-based focal intracranial hypothermia combined with endovascular reperfusion therapy for…
- Trial name
- RESCUE-LCI (NCT07232082)
- Testing
- intra-arterial local therapeutic hypothermia, Control (Normal saline)
- Volunteers
- 322 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Ischemic Stroke
SITS (Safe Implementation of Treatments in Stroke) Open Artery by Thrombectomy in Acute Occlusive Stroke Study
Ischemic stroke, i.e. irreversible damage of a part of the patient's brain, is caused by the formation of blood clot in the major vessel which gives blood supply to a certain part of the brain.
- Trial name
- SITS Open (NCT02326428)
- Testing
- Stent retriever endovascular device for thrombectomy, Intravenous thrombolysis by alteplase (Actilyse) (optional)
- Where
- Sweden
- Volunteers
- 341 people
- Sponsor
- Karolinska Institutet
Stroke, Vascular Occlusion
REperfusion Therapy for Acute Ischemic STrOke Due to Large aRtEry Occlusion
The aim of the study was to establish a clinical and advanced imaging database of acute ischemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion of anterior circulation within 24 hours from…
- Conditions
- Stroke, Vascular Occlusion, Endovascular Treatment, Mechanical Thrombectomy
- Trial name
- RESTORE (NCT05311605)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Endovascular Treatment
Normobaric Hyperoxia Combined With Endovascular Treatment for Acute Ischemic Stroke
The purpose of this study is to evaluate the safety and efficiency of normobaric hyperoxia combined with endovascular treatment for acute ischemic stroke patients with stroke onset 6-24 hours.
- Conditions
- Stroke, Endovascular Treatment, Neuroprotection
- Trial name
- NCT05128422
- Testing
- Normobaric oxygen therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Navigated Transcranial Magnetic Stimulation in Monitoring Stroke Recovery
The past 10 years of research in persons more than 6 months post stroke have shown certain types of rehabilitation can help "re-wire" the brain.
- Trial name
- NCT01005394
- Testing
- Navigated TMS examination
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nexstim Ltd
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