Clinical trials: Stroke, Acute, Ischemic
Stroke
Efficacy, Safety, Tolerability and Pharmacokinetics of SUN13837 to Treat Acute Stroke
The purpose of this study is to evaluate the safety and tolerability of SUN13837 and to determine whether SUN13837 improves the physical performance, relative to placebo, following an acute stroke in adult subjects.
- Trial name
- NCT02258880
- Testing
- SUN13837
- Where
- 53 sites in United States, Canada and 2 more
- Sponsor
- Daiichi Sankyo
Stroke Acute
Fusion Imaging in Endovascular Thrombectomy for Acute Ischemic Stroke
Endovascular thrombectomy (EVT) is the standard of care for acute ischemic stroke (AIS) caused by a large vessel occlusion. Successful recanalization is one of the most important factors for a good patient outcome, especially…
- Trial name
- FUSE-IT (NCT06975696)
- Testing
- Standard endovascular thrombectomy with Fusion, Standard EVT without Fusion
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Ischemic Stroke
A Safety and Effective Study of Ginkgolides Diterpene Lactone Meglumine Injection in the Treatment of Ischemic Stroke.
The aim of this study is to evaluate the safety and effectivity of Ginkgo diterpene lactone meglumine injection tn the treatment of acute ischemic stroke
- Trial name
- NCT02526225
- Testing
- Ginkgo diterpene lactone meglumine injection, Ginkgo diterpene lactone meglumine injection simulation
- Where
- China
- Volunteers
- 3,452 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ichemic Stroke, Anterior Cerebral Artery Stroke
Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial
The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with…
- Conditions
- Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
- Trial name
- NCT07449910
- Testing
- 2mg Baricitinib, 4mg Baricitinib, Guideline-based therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Ischemic Stroke
Efficacy and Safety of Early Combined Therapy With PCSK9 Inhibitors and Statins in Acute Ischemic Stroke
This study is an investigator-initiated, multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial (PROBE design) that includes patients with moderate or severe symptomatic intracranial large vessel…
- Trial name
- CAPTAIN (NCT06696820)
- Testing
- PCSK9 inhibitors combined with atorvastatin/rosuvastatin, Atorvastatin/Rosuvastatin
- Where
- 2 sites in China
- Volunteers
- 429 people
- Sponsor
- Xiang Luo
Acute Ischemic Stroke
Registry of Acute Ischemic Stroke With Large- or Medium-vessel Occlusion
This study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.
- Trial name
- LOMEVO (NCT05779215)
- Testing
- Visit at D90
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute, Stroke Ischemic
Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance
Ischemic stroke is a major health burden globally and in Australia. Treatment for ischemic stroke is time critical and is significantly more effective if administered within the first 90 minutes of symptom onset.
- Trial name
- TASTEa (NCT04071613)
- Testing
- Tenecteplase, Intravenous tissue plasminogen activator (tPA)
- Where
- 5 sites in Australia
- Volunteers
- 104 people
- Sponsor
- Melbourne Health
Acute Ischemic Stroke
Comparing Between CO2 and Phenylephrine Treatment in Patients With Progressive Lacunar Infarction (CARBOGEN Study)
Lacunar infarction is an ischemic stroke occurred by small perforating artery occlusion . Twenty percent of ischemic stroke is lacunar infarction.
- Trial name
- NCT04839224
- Testing
- carbogen, phenylephrine
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- Yonsei University
Mild Stroke
Tirofiban With Sequential Dual Antiplatelet Therapy in Mild Stroke
This study aims to evaluate whether initiating intravenous tirofiban within 48 hours of onset (with a 48-hour infusion), followed by sequential DAPT, can improve the likelihood of excellent functional outcomes (modified Rankin…
- Trial name
- TiMIS (NCT07095790)
- Testing
- Tirofiban+Oral Dual Antiplatelet Therapy, Oral Dual Antiplatelet Therapy
- Where
- 18 sites in China
- Volunteers
- 580 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Acute Stroke
Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke
Background and Rationale: Cerebrovascular disease is always ranked at the top causes of death and most of hospitalized acute stroke patients have ischemic stroke [1].
- Trial name
- NCT03431402
- Testing
- Hyperbaric oxygen
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Stroke, Transient Ischemic Attack
Preventing Recurrent Stroke in Minority Populations
This study focuses on causes of under-use of secondary stroke preventive measures demonstrated in randomized clinical trials to be efficacious, but not appropriately utilized in urban, minority populations.
- Trial name
- NCT00211731
- Testing
- Chronic Disease Self Management Course
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ischemic Stroke
Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
The investigators hypothesize that Acute Thai traditional massage will yield beneficial effects on cerebrovascular reactivity in ischemic stroke patients.
- Trial name
- NCT02270294
- Testing
- Thai traditional massage, No massage
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Chulalongkorn University
Acute Ischemic Stroke, Intracranial Arteriosclerosis
Stroke Imaging Package Study
Our study aims to explore the value of new imaging technique package in predicting early neurological deterioration (END) as well as 90-day unfavorable outcome in patients with acute ischaemic stroke.
- Conditions
- Acute Ischemic Stroke, Intracranial Arteriosclerosis, Cerebral Small Vessel Diseases
- Trial name
- SIPS (NCT02485275)
- Where
- 16 sites in China
- Volunteers
- 949 people
- Sponsor
- Wei-Hai Xu
Ischemic Stroke
Perfusion Computer Tomography: Imaging and Clinical Validation Following Reperfusion Therapy in Acute Ischaemic Stroke
CT perfusion (CTP) of the brain is an innovative technique to identify rapidly regions which are only partially or insufficiently perfused during an acute ischemic event.
- Trial name
- NCT02309970
- Testing
- acetylsalicylic acid, clopidogrel bisulfate and/or warfarin, Apixaban, Rivaroxaban, Dabigatran, alteplase, endovascular
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Rabin Medical Center
Acute Ischemic Stroke
HRS-7450 Injection Phase II Clinical Trial for Acute Ischemic Stroke.
This study plans to enroll a total of 208 patients with Acute Ischemic Stroke (AIS) who present within 4.5 to 24 hours of symptom onset and meet the specified imaging criteria.
- Trial name
- NCT07233070
- Testing
- HRS-7450 Injection
- Where
- 2 sites in China
- Volunteers
- 210 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Stroke, Ischemic
INtravenous TNK for Acute isChemicsTroke in China
Acute ischemic stroke is the most common type of stroke, accounting for about 60%-80% of all stroke, with high incidence, high mortality, high disability rate, has become the first cause of death in China.
- Trial name
- NCT04588337
- Testing
- rhTNK-tPA
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- General Hospital of Shenyang Military Region
Ischaemic Stroke
Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis
The aim of this study is to assess the efficacy and safety of minocycline in improving functional outcome among patients with acute ischaemic stroke receiving intravenous thrombolysis.
- Trial name
- EMPHASIS-2 (NCT07526987)
- Testing
- Minocycline Hydrochloride Capsule (50 mg per capsule)
- Where
- 3 sites in China
- Volunteers
- 934 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute, Stroke, Ischemic
Magnetically Enhanced Diffusion for Acute Ischaemic Stroke (MEDIS) Trial
The objective of the MEDIS study is to determine if subjects experiencing an Acute Ischaemic Stroke due to large vessel occlusion, treated with IV tPA combined with the MED procedure have a greater likelihood of recanalisation…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Infarction, Middle Cerebral Artery, Strokes Thrombotic
- Trial name
- MEDIS (NCT03098732)
- Testing
- Magnetically Enhanced Diffusion (MED)
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Pulse Therapeutics
Acute Ischemic Stroke
An fNIRS Study of Motor Cortical Activation in Stoke Patients
The investigators evaluate the activation and connectivity of patients' motor regions in the acute phase of ischemic stroke by fNIRS.
- Trial name
- NCT05376098
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute Ischemic
Endovascular Treatment for eXtra-Large Ischemic Stroke
The role of endovascular thrombectomy in patients with extra-large ischemic burden is still unclear. The XL STROKE-2 randomized trial is aiming to investigate the efficacy and safety of mechanical thrombectomy in acute…
- Trial name
- XL STROKE-2 (NCT06388148)
- Testing
- Medical management, Endovascular thrombectomy
- Where
- 2 sites in China
- Volunteers
- 286 people
- Sponsor
- Zhongming Qiu
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