Clinical trials: Stroke, Acute, Ischemic
Stroke, Ischemic
Low-Intensity Monitoring Nursing After Thrombolysis for Acute Ischemic Stroke
This cluster-randomized study compares a lower-frequency post-thrombolysis monitoring pathway with a standard pathway in adults with acute ischemic stroke.
- Trial name
- OPTINursing (NCT07865598)
- Testing
- lower frequency of assessment of neurological impairment and vital signs, standard frequency of assessment of neurological impairment and vital signs
- Volunteers
- 864 people
- Sponsor
- Shengjing Hospital
Ischemic Stroke
Tenecteplase Thrombolytic Therapy for Acute Ischemic Stroke in China
The objective of the study is to investigate the effectiveness and safety of rhTNK-tPA in acute ischemic stroke patients within 4.5 hours of symptom onset in a real-world clinical setting.
- Trial name
- TTT-AIS CHINA (NCT06078995)
- Testing
- Tenecteplase, Alteplase
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Huashan Hospital
Stroke
Desmoteplase in Acute Ischemic Stroke (DIAS)
The DIAS study (Part 2) was performed to support the dose finding of desmoteplase treatment in subjects with acute ischemic stroke selected by perfusion/diffusion mismatch on MRI within a time window of 3 to 9 h after…
- Trial name
- NCT00638781
- Testing
- Desmoteplase
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- PAION Deutschland GmbH
Ischemic Stroke
A Study to Evaluate the Efficacy and Safety of Renexin CR in Patients With Acute Non-cardioembolic Ischemic Stroke
A study to Evaluate the Efficacy and Safety of Renexin CR in patients with Acute Non-cardioembolic Ischemic Stroke
- Trial name
- NCT05445895
- Testing
- Renexin CR 200/160mg, Plavix 75mg
- Where
- South Korea
- Volunteers
- 483 people
- Sponsor
- SK Chemicals Co., Ltd.
Acute Ischemic Stroke
Efficacy and Safety of Human Urinary Kallidinogenase Combined With Reteplase Intravenous Thrombolysis in the Treatment of Acute Ischemic Stroke
This study is a multicentre, randomized, blinded-endpoint trial that aims to evaluate the efficacy and safety of human urinary kallidinogenase combined with reteplase intravenous thrombolysis in the treatment of acute ischemic…
- Trial name
- KREATE (NCT07483281)
- Testing
- Human Urinary Kallidinogenase, Clinical Routine Treatment
- Where
- China
- Volunteers
- 220 people
- Sponsor
- China-Japan Union Hospital
Stroke, Acute, Stroke, Ischemic
Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours
This is a multicenter, open-label, evaluator-blinded, investigator-initiated, randomized clinical trial, to evaluate the clinical efficacy and safety of LF-rTMS in reducing infarct size, reducing disability rate and improving…
- Trial name
- RETRACE-I (NCT06064734)
- Testing
- LF-rTMS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Acute Arterial Ischemic Stroke
Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke
Acute ischemic stroke affects roughly 1 in 50,000 children every year and is one of the top ten causes of death in children. Currently, caregivers lay the affected child flat in hopes of increasing blood flow to the brain and…
- Trial name
- NCT01786785
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Stroke, Stroke, Acute
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- VERIFY (NCT05338697)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 45 sites in United States
- Volunteers
- 657 people
- Sponsor
- Yale University
Ischemic Stroke
Efficacy of BNG-1 to Treat Acute Ischemic Stroke
The objective of this study is to investigate the efficacy and safety of BNG-1 in patients with ischemic stroke. The efficacy assessment will be based on the functional outcome while the safety will be reviewed by the adverse…
- Trial name
- BNG-1 (NCT01675115)
- Testing
- BNG-1, Aspirin
- Where
- Taiwan
- Volunteers
- 129 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Ischemic Stroke, Basilar Artery Occlusion
Basilar Artery Occlusion Chinese Endovascular Trial in the Extended Time Window
A prospective, multi-center, randomized, controlled, open-label, blinded-endpoint trial to evaluate the safety and efficacy of endovascular mechanical thrombectomy for acute basilar artery occlusion in the extended time window
- Trial name
- BAOCHE2 (NCT06560203)
- Testing
- Mechanical thrombectomy
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Capital Medical University
Hypothermia, Stroke, Acute
Short-duration Selective Brain Cooling for Patients Undergoing Mechanical Thrombectomy
To determine the efficacy and safety of short-duration intra-artery selective brain cooling in addition to mechanical thrombectomy in patients with acute ischemic stroke.
- Trial name
- NCT03163459
- Testing
- selective brain cooling by cold saline perfusion, mechanical thrombectomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Infarction, Brain, Embolism
Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome
This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF.
- Conditions
- Infarction, Brain, Embolism, Atrial Fibrillation
- Trial name
- NCT06018090
- Testing
- The presence and rate of MES measured by TCD monitoring
- Where
- Portugal
- Volunteers
- 61 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Acute Ischemic Stroke
Normobaric Hyperoxia Stabilizing Ischemic Penumbra
To investigate the safety and efficacy of normobaric hyperoxia (NBO) stabilizing penumbra in acute ischemic stroke patients.
- Trial name
- NCT05781880
- Testing
- Oxygen 100%
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Ji Xunming,MD,PhD
Ischemic Stroke
Multidetector Raw CT as a Single Tool in the Setting of Ischemic Stroke
This is a prospective study including acute ischemic stroke patients aged 18 to 90. Multidetector raw CT is performed in acute ischemic stroke patients.
- Trial name
- COCASE (NCT00708188)
- Testing
- Multidetector raw CT
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Hospices Civils de Lyon
Acute Ischemic Stroke
RIsE Stroke Mobility Study
This study is designed to better understand how patients with severe stroke move during their hospital stay. It will track their activity using a small wearable device (activPAL) along with standard mobility information already…
- Trial name
- RIsE (NCT07638462)
- Testing
- activPAL device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Acute Ischemic Stroke
Safety and Efficacy Evaluation of the Ceretrieve Device in the Treatment of AIS Patients
The main objective of this clinical trial is to evaluate of the safety \& efficacy of the Ceretrieve device within 24 hours post thrombectomy procedure.
- Trial name
- NCT06733246
- Testing
- Aspiration 0
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- Ceretrieve Ltd.
Stroke, Stroke, Acute
Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies
Endovascular thrombectomy (EVT) is a highly effective therapy for acute ischemic stroke with large vessel occlusion (LVO). EVT was proven efficacious in selected patients with symptoms onset or last-known-well time of up to 24…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Brain Diseases
- Trial name
- GALLOP (NCT05920889)
- Testing
- Semaglutide
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Acute Ischemic Stroke
Study Evaluating Single Ascending Doses Of ILS-920
This is a first-in-human study of ILS-920. This study will provide an initial assessment of the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ILS-920 after administration of ascending single…
- Trial name
- NCT00827190
- Testing
- ILS-920
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Stroke, Ischemic, Tomography, X-Ray Computed
DECT for Differentiating Intracerebral Hemorrhage From Contrast Extravasation
The goal of this clinical trial is to investigate the use of DECT (Dual-Energy Computed Tomography) in patients with acute ischemic stroke who receive an intervention (thrombolysis or thrombectomy).
- Trial name
- DECT-ICH (NCT05675774)
- Testing
- Dual Energy CT
- Where
- Canada
- Volunteers
- 189 people
- Sponsor
- University of Manitoba
Ischemic Stroke, Atrial Fibrillation
TIMING of Oral Anticoagulant Therapy in Acute Ischemic Stroke With Atrial Fibrillation
This study will compare early with late start of treatment with Non-vitamin K oral anticoagulation (NOAC) in adult patients with acute ischemic stroke and atrial fibrillation; it is a registry-based randomized clinical trial…
- Trial name
- NCT02961348
- Testing
- Early start of NOAC, Late start of NOAC
- Where
- 36 sites in Sweden
- Volunteers
- 888 people
- Sponsor
- Uppsala University
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