Clinical trials: Stroke, Acute, Ischemic
Stroke, Acute, Neuroprotection
Normobaric Hyperoxia With Extended-Window Endovascular Therapy for Acute Ischemic Stroke (OPENS-EXTEND)
Although endovascular therapy (EVT) has substantially improved recanalization rates and extended the treatment window for acute ischemic stroke, fewer than half of patients achieve functional independence despite successful…
- Conditions
- Stroke, Acute, Neuroprotection, Normobaric Hyperoxia, Endovascular Treatment
- Trial name
- NCT07717216
- Testing
- Oxygen (Normobaric Hyperoxia), Endovascular Therapy
- Volunteers
- 314 people
- Sponsor
- Weifang Medical University
Stroke Ischemic, Stroke Acute
Posterior Circulation ASTRAL Prognostic Score
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke…
- Conditions
- Stroke Ischemic, Stroke Acute, Posterior Circulation Brain Infarction, Risk Score
- Trial name
- NCT05906420
- Testing
- ASTRAL prognostic score
- Where
- 2 sites in Greece, Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University of Thessaly
Acute Ischemic Stroke
Randomized Study of Bailout Intracranial Angioplasty Following Thrombectomy for Acute Large Vessel Occlusion
Unfavorable outcomes were associated with failed thrombectomy of acute large vessel occlusions (LVO). The failed thrombectomy rate was 12-41% reported in multiple randomized controlled trials (RCT).
- Trial name
- ANGEL-REBOOT (NCT05122286)
- Testing
- Bailout angioplasty, Standard therapy
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Acute Stroke Advancing Program Using Telemedicine
The purpose is to evaluate the effectiveness and safety profile of telemedicine consultation system in making decision on IV thrombolysis.
- Trial name
- ASAP-Tel (NCT02088346)
- Testing
- Telemedicine consultation system
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Stroke, Acute, Atrial Fibrillation
RELAXED: Recurrent Embolism Lessened by Rivaroxaban for Acute Ischemic Stroke
Early recurrence of cardioembolic stroke in patients with atrial fibrillation is common, reaching approximately 6% within 30 days after initial stroke.
- Trial name
- RELAXED (NCT02129920)
- Testing
- This is an observational study
- Where
- Japan
- Volunteers
- 2,000 people
- Sponsor
- Japan Cardiovascular Research Foundation
Stroke
An AI-Based CDSS for Integrated Management of Patients With Acute Ischemic Stroke(GOLDEN BRIDGE II)
This study will conduct a cluster randomized controlled trial to evaluate the impact of an artificial intelligence-based clinical decision support system for the integrated management of patients with acute ischemic stroke on the…
- Trial name
- NCT04524624
- Testing
- AI-based CDSS
- Where
- China
- Volunteers
- 21,689 people
- Sponsor
- Beijing Tiantan Hospital
Endovascular Therapy, Acute Ischaemic Stroke
Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke
The RESCUE-BP is a multi-centered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. In patients with acute ischemic stroke who have undergone endovascular treatment and achieved successful…
- Conditions
- Endovascular Therapy, Acute Ischaemic Stroke, Collateral Circulation, Blood Pressure Management
- Trial name
- RESCUE-BP (NCT07527013)
- Testing
- Stratified Blood Pressure Management
- Where
- China
- Volunteers
- 544 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Safety Study of the Rapid System for Acute Ischemic Stroke
This is a safety study of the Rapid System for acute ischemic stroke.
- Trial name
- NCT01404403
- Testing
- Rapid System
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Rapid Medical
Acute Ischemic Stroke
IDEAL Blood Pressure Management During Endovascular Therapy for Acute Ischemic Stroke
The ideal blood pressure management strategy during endovascular therapy (EVT) for acute ischemic stroke has not been defined. The aim of this pilot randomized clinical trial is to determine whether randomization to a standard…
- Trial name
- IDEAL (NCT04749251)
- Testing
- Individualized blood pressure management, Standard blood pressure management
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Stroke
Which Parameters of Short-term Blood Pressure Variability Best Predict Early Outcomes in Acute Ischemic Stroke
Previous studies on the association between blood pressure variation (BPV) in acute ischemic stroke and functional outcomes yield conflicting result.
- Trial name
- BPV (NCT02675972)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Dongguan People's Hospital
Acute Ischaemic Stroke
Efficacy and Security of an Endovascular Treatment as First Choice Procedure Compared With a Standard Intravenous Thrombolytic Therapy Treatment for Patients With Acute Ischemic Stroke Within 4.5 Hours After Onset
This study will compare two ways of treatment for acute ischemic stroke: an endovascular treatment (EVT), defined as intraarterial thrombolysis and/or mechanical thrombectomy as a first choice treatment versus intravenous…
- Trial name
- FUN-TPA (NCT02164357)
- Testing
- EVT (endovascular treatment ), IVT (intravenous thrombolytic therapy)
- Where
- 5 sites in Spain
- Volunteers
- 124 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Large Artery Occlusion Treated in Extended Time With Mechanical Thrombectomy Trial
A multi-center, prospective, randomized, open-label, adaptive group sequential designed, blinded endpoint assessment (PROBE) clinical trial of endovascular treatment among selected AIS
- Trial name
- LATE-MT (NCT05326932)
- Testing
- Mechanical thrombectomy
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Lili SONG
Acute Ischemic Stroke (AIS)
Safety and Pharmacokinetics of MCI-186 in Subjects With Acute Ischemic Stroke
The objectives of this study are to assess the safety, tolerability and local tolerance, and to investigate the plasma levels and terminal elimination half life of MCI-186, and to review the routine clinical and neurological…
- Trial name
- NCT00821821
- Testing
- MCI-186
- Where
- 3 sites in Finland, Netherlands and 1 more
- Volunteers
- 36 people
- Sponsor
- Shionogi
Ischemic Stroke, Acute, Ischemia-reperfusion Injury
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury
The study is a two-center prospective cohort clinical trial. The primary purpose of this trial is to identify the pattern of DKK2 serum levels in ischemic stroke patients after revascularization therapy and determine the…
- Conditions
- Ischemic Stroke, Acute, Ischemia-reperfusion Injury, Cerebral Edema
- Trial name
- NCT05585255
- Testing
- enzyme-linked immunosorbent assay(ELISA)
- Where
- 2 sites in China
- Volunteers
- 108 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Ischemic Stroke
Safety and Effectiveness of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis in Treating Acute Ischemic Stroke
The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning combined with intravenous thrombolysis in treating acute ischemic stroke.
- Trial name
- SERICT-AIS (NCT04027621)
- Testing
- remote ischemic conditioning
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yi Yang
Ischemic Stroke
Sedation Versus General Anesthesia for Endovascular Therapy in Acute Stroke - Impact on Neurological Outcome
The purpose of this study is to evaluate whether general anesthesia or sedation technique is preferable during embolectomy for stroke, measured in terms of three months neurological impairment.
- Trial name
- ANSTROKE (NCT01872884)
- Testing
- Sevorane Remifentanil, Remifentanil
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Sahlgrenska University Hospital
Acute Ischemic Stroke, AIS
A Phase I Trial of Umbilical Cord Mesenchymal Stromal Cells for Acute Ischemic Stroke
Study Methods: The trial consists of two phases, both including a placebo control. Phase Ia (single-dose, dose-escalation): Three dose groups (low, medium, high) are set.
- Trial name
- NCT07628933
- Testing
- Human Umbilical Cord Mesenchymal Stem Cells Injection
- Where
- China
- Volunteers
- 35 people
- Sponsor
- BOE Technology Group Co., Ltd.
Ischemic Stroke, Indobufen
INdobufen Versus aSpirin in acUte Ischemic stRokE,INSURE
China has the largest burden of cerebrovascular disease in the world. About 60% to 80% of which are ischemic stroke. In recent years, stroke has replaced heart disease and tumor diseases as the first cause of death and disability…
- Conditions
- Ischemic Stroke, Indobufen, Aspirin
- Trial name
- NCT03871517
- Testing
- Indobufen, Aspirin
- Where
- China
- Volunteers
- 5,438 people
- Sponsor
- Beijing Tiantan Hospital
Endovascular Thrombectomy, Ischemic Cerebrovascular Accident
A Trial to Assess the Efficacy and Safety of OTR4132-MD in Patients With Acute Ischemic Stroke
The MaTRISS 2 study is a phase 2 randomized, double-blinded and placebo-controlled trial aimed at recruiting 60 subjects (30 placebo and 30 active) from 15 stroke centers in France.
- Trial name
- MATRISS-II (NCT06700824)
- Testing
- OTR4132
- Where
- 15 sites in France
- Volunteers
- 60 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement
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