Clinical trials: Stroke, Acute, Ischemic
Acute Ischemic Stroke
Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke
The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning for acute ischemic stroke.
- Trial name
- NCT04980651
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 2,210 people
- Sponsor
- Yi Yang
Stroke, Acute Ischemic
Y-3 Injection Through Skull Bone Marrow in the Treatment of Acute Malignant Middle Cerebral Artery Infarction (SOLUTION)
The mortality of malignant middle cerebral artery infarction (mMCAI) is up to 80%, while current available treatment is limited.
- Trial name
- NCT05849805
- Testing
- Intracalvaria bone marrow injection, Conventional treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute Ischemic Stroke
Extended Time Window Intravenous Thrombolysis Registry for Acute Ischemic Stroke
The EXTEND-IVT Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous thrombolysis administered beyond 4.5 hours after last known well in patients with…
- Trial name
- EXTEND-IVT (NCT07536074)
- Testing
- Intravenous Thrombolysis
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Ischemic Stroke, Atrial Fibrillation
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study will determine whether early, comprehensive, rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care.
- Trial name
- EAST-STROKE (NCT05293080)
- Testing
- Medical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version), Usual care for atrial fibrillation
- Where
- Germany
- Volunteers
- 1,746 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ischemic Stroke, Endothelial Dysfunction
The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients
Patients presenting with acute cerebral ischemic events are randomly assigned into aspirin (n=40) or cilostazol (n=40) group in a double-blinded manner. FMD is measured as a primary outcome at baseline (T0) and 90 days (T1).
- Trial name
- PASS (NCT03116269)
- Testing
- Cilostazol 100mg, Aspirin
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Ajou University School of Medicine
Stroke, Cerebrovascular Accident
Intra-arterial Versus Systemic Thrombolysis for Acute Ischemic Stroke
SYNTHESIS is a pragmatic multicenter randomized controlled trial (RCT), open-label, with blinded follow-up aiming to determine whether loco-regional intra-arterial (IA) with recombinant tissue-plasminogen activator (rt-PA) and/or…
- Trial name
- SYNTHESIS EXP (NCT00640367)
- Testing
- Alteplase IA and/or mechanical thrombolysis, Alteplase IV
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Niguarda Hospital
Acute Stroke
Multi-"Omics" Research of Danhong Injection to Treat Acute Ischemic Stroke
The purpose of this study is to explore the pharmacological mechanism of Danhong injection in the treatment of acute ischemic stroke.
- Trial name
- NCT02176395
- Testing
- Danhong injection, Standard medical care
- Where
- 4 sites in China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- China Academy of Chinese Medical Sciences
Ischemia Stroke, TIA (Transient Ischemic Attack)
Upfront Lipid-Lowering Therapy With Statins Combined With Hybutimibe in Patients With Acute Ischemic Stroke or Transient Ischemic Attack.
This study aims to evaluate whether an upfront combination lipid-lowering therapy (statins combined with hybutimibe) can further improve the 8-week LDL-C target achievement rate (<1.8 mmol/L and ≥50% reduction from baseline)…
- Trial name
- NCT07908875
- Testing
- Atorvastatin, Hybutimibe 10mg QD
- Volunteers
- 520 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Ischemic Stroke, Acute, Treatment Outcome
Effect of Early Versus Late Initiation of Edaravone Dexborneol on Neural Function in Patients With Acute Ischemic Stroke
The primary objective of this study was to evaluate the efficacy and safety of initiation of edaravone dextivel therapy compared with placebo in patients with acute ischaemic stroke (early and late) and to explore the optimal…
- Trial name
- EARLYS (NCT05885919)
- Testing
- Edaravone Dexborneol Concentrated Solution for injection
- Where
- 3 sites in China
- Volunteers
- 212 people
- Sponsor
- Xiangya Hospital of Central South University
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours
This study will address the efficacy and safety of Tenecteplase administered in non-endovascular capable center (nECC) in patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (acLVO) who…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Transportation of Patients
- Trial name
- TREASURE (NCT07253181)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- 2 sites in China
- Volunteers
- 572 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemia, Stroke
Edoxaban for TIA and Acute Minor Stroke
Transient ischemic attack (TIA) or minor ischemic stroke has a high risk of early recurrent stroke. As the golden standard, aspirin effect modestly on acute ischemic stroke, and slightly increase the risk of intracerebral…
- Conditions
- Ischemia, Stroke, Cerebral Infarction
- Trial name
- NCT02221102
- Testing
- Aspirin, edoxaban
- Where
- China
- Volunteers
- 3,700 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke
Clinical Study of Desmoteplase in Japanese Patients With Acute Ischemic Stroke
The purpose of the study is to evaluate whether desmoteplase is safe and tolerated when given to Japanese patients with acute ischemic stroke
- Trial name
- DIAS-J (NCT01104467)
- Testing
- Desmoteplase
- Where
- 19 sites in Japan
- Volunteers
- 48 people
- Sponsor
- Lundbeck Japan K. K.
Acute Ischemic Stroke
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Ischemic Stroke
he purpose of this study is to determine the efficacy and safety of remote ischemic conditioning for acute ischemic stroke.
- Trial name
- SERIC-AIS (NCT03669653)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 912 people
- Sponsor
- Yi Yang
Acute Ischemia
Acute Ischemic Apoplexy Syndrome Specificity and Acupuncture Intervention Research
This project optimizes the TCM Symptoms and Symptoms Scale. A curative effect evaluation system of acupuncture in the treatment of acute ischemic stroke is formed to provide clinical evidence by the following indexes…
- Trial name
- AIAI (NCT04528472)
- Testing
- Acupuncture Treatment, Regular Treatment
- Volunteers
- 194 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Acute Ischemic Stroke (AIS), Stroke-Associated Pneumonia (SAP)
Oral Care Strategies for Stroke Patients with Dysphagia
This study aims to evaluate whether combining neuromuscular electrical stimulation (NMES) with oral care can improve swallowing function in patients who have experienced an acute stroke and are dealing with dysphagia (difficulty…
- Conditions
- Acute Ischemic Stroke (AIS), Stroke-Associated Pneumonia (SAP), Dysphagia Following Cerebrovascular Accident
- Trial name
- NCT06692101
- Testing
- oral care, Neuromuscular Electrical Stimulation (NMES)
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Stroke, Visual Field Loss
Fluoxetine for Visual Recovery After Ischemic Stroke
The purpose of this study is to determine whether fluoxetine, a selective serotonin reuptake inhibitor commonly used for depression, enhances visual recovery after an acute ischemic stroke.
- Trial name
- FLUORESCE (NCT02737930)
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Bogachan Sahin
Stroke, Ischemic
Argatroban Combined With Antiplatelet Versus Antiplatelet for Acute Ischemic Stroke
Intravenous thrombolysis is considered as the first choice for ischemic stroke. In the recent years, endovascular therapy is demonstrated to be effective to treat ischemic with big vessel occlusion.
- Trial name
- NCT03552354
- Testing
- Argatroban plus dual antiplatelet
- Where
- China
- Volunteers
- 120 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication
ECMO ABI Detection With Hyperfine
The primary objective is to characterize the prevalence and type of ABI following cannulation for pediatric patients who require ECMO support.
- Conditions
- Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication, Hypoxia-Ischemia, Brain, Stroke, Acute
- Trial name
- NCT06469801
- Testing
- Hyperfine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Ischemic Stroke, Acute
Human Induced Neural Stem Cell-derived Exosomes for Treating Acute Ischemic Stroke
A phase I/IIa clinical trial investigating the safety and preliminary efficacy of intravenous administration of human induced neural stem cell-derived exosomes for acute ischemic stroke
- Trial name
- NSAIS (NCT07143786)
- Testing
- iNSC-EV01
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute
Acute Stroke: Prehospital Versus In-HospitAL Initiation of Recanalization Therapy- ASPHALT
ASPHALT is an academic-driven open-label randomized controlled trial of Mobile Stroke Unit (MSU) deployment versus standard care in France, with blinded assessment of efficacy endpoints.
- Trial name
- ASPHALT (NCT05649670)
- Testing
- Mobile Stroke Unit deployment
- Where
- 11 sites in France
- Volunteers
- 450 people
- Sponsor
- Centre Hospitalier St Anne
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.