Clinical trials: Stroke, Acute, Ischemic
Stroke
Contribution of a High-resolution Diffusion Sequence at 3T for the Detection of Acute Punctate Ischemic Brain Lesions
Stroke is a public health issue and a priority for our institution. MRI plays an essential role in the management of stroke, its contribution being diagnostic, etiological and prognostic.
- Trial name
- STROKE_HR (NCT05232500)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Acute Ischemic Stroke, Cerebral Edema
The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers
This is a single-center, randomized, double-blind, placebo-controlled Phase I clinical study to evaluate the tolerability, safety, and pharmacokinetic characteristics of SIM1910-09 for injection after single/multiple dosing in…
- Trial name
- NCT05200728
- Testing
- SIM1910-09
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Ischemic Stroke, Acute
Analyzing the Pharmacodynamic Substances and the Effects of Xingnaojing for Mild-to-Severe Acute Ischemic Stroke
The main purposes of this trial are to analyze the pharmacodynamic substances and the effects of Xingnaojing for mild-to-severe acute ischemic stroke.
- Trial name
- PUBLISH (NCT05559307)
- Testing
- Xingnaojing injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ying Gao
Acute Ischemic Stroke
Evaluation of Xueshuantong in Patients With AcutE IschemiC STroke
The aim is to assess the effects and harms of Xueshuantong lyophilized powder versus placebo in patients with acute ischemic stroke when initiated within 72 hours of symptom onset.
- Trial name
- EXPECT (NCT04415164)
- Testing
- Xueshuantong lyophilized powder, Guidelines-based standard care
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Dongzhimen Hospital, Beijing
Stroke, Acute Ischemic Stroke
Safety and Efficacy of Adjunctive GM1 to Mechanical Thrombectomy for Acute Anterior Circulation Large Vessel Occlusion
Stroke is a leading cause of global mortality and morbidity, with acute ischemic stroke (AIS) accounting for approximately 65.3% of cases and resulting in roughly 3.4 million new cases annually in China.
- Trial name
- IAT-GIANT (NCT07519044)
- Testing
- Intravenous GM1 Therapy
- Where
- 2 sites in China
- Volunteers
- 868 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Acute, Neuroprotection
Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion
The goal of this clinical trial is to determine if direct ischemic post-conditioning (IPostC) can alleviate ischemic-reperfusion injury (I/R) in patients who have undergone endovascular thrombectomy (EVT).
- Conditions
- Stroke, Acute, Neuroprotection, Ischemic Conditioning
- Trial name
- NCT06545734
- Testing
- Direct Ischemic Post-conditioning, Endovascular therapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Huanhu Hospital
Sleep-Disordered Breathing, Sleep Architecture
Screening of OSA in Hospitalized Stroke Patients Using BSP
Obstructive sleep apnea (OSA) is prevalent in patients with stroke and has a negative effect on outcomes by predisposing them to recurrent stroke, increasing mortality, and so forth.
- Conditions
- Sleep-Disordered Breathing, Sleep Architecture, Stroke, Acute
- Trial name
- NCT05466864
- Testing
- Belun Sleep platform
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Stroke Acute, Cytoprotection
Ischemic Postconditioning in Acute Stroke Patients Receiving Endovascular Thrombectomy
This clinical trial will evaluate whether on-site ischemic postconditioning (IPostC) improves outcomes in acute stroke patients receiving endovascular thrombectomy (EVT) and explore its mechanisms.
- Conditions
- Stroke Acute, Cytoprotection, Ischemic Conditioning
- Trial name
- NCT06967025
- Testing
- Ischemic Postconditioning, Endovascular Thrombectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Cerebral Edema, Ischemic Stroke, Acute
A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke
The primary objective is to investigate whether treatment with Adacolumn can ameliorate the progression of cerebral edema within 72 hours in patients with anterior circulation ischemic stroke.
- Conditions
- Cerebral Edema, Ischemic Stroke, Acute, Malignant Cerebral Edema, Anterior Circulation Brain Infarction
- Trial name
- NCT07386262
- Testing
- Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Ischemic Stroke
SLGT2i for Neuroprotection in Patients With Acute Ischemic Stroke
Stroke is a leading cause of disability and mortality globally. With population aging, ischemic stroke (80% of cases) has become China's primary cause of adult disability.
- Trial name
- NCT07105917
- Testing
- SGLT-2 inhibitors, Standard medical treatment
- Volunteers
- 1,050 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stroke, Acute Ischemic
Community Health Worker Assisted Task Specific and Cognitive Therapy at Home With Exposure After Stroke
CATCHES is a novel intervention for preliminary testing, integrating Task Specific Therapy at home guided by Community Health Workers (CHW) under supervision of a licensed Physical Therapist (PT) guided by telehealth based…
- Trial name
- CATCHES (NCT06314308)
- Testing
- CATCHES
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Acute Ischemic Stroke AIS
Balloon Guide Versus Conventional Guide Catheter in Stroke Thrombectomy
The purpose of this clinical trial is to study the two main types of approaches used in stroke thrombectomy and to investigate if one approach is more effective than the other, as this is currently not known.
- Trial name
- 2Guide (NCT07085390)
- Testing
- Use of a Balloon Guide Catheter, Use of a Conventional (non-balloon) Guide Catheter
- Where
- 2 sites in United States
- Volunteers
- 186 people
- Sponsor
- University of South Florida
Acute Ischemic Stroke
Physical Activity Immediately After Acute Cerebral Ischemia 3
Stroke is the leading cause of adult disability in Europe and United States and the second leading cause of death worldwide and affects more than 10,000 Danes each year.
- Trial name
- NCT01712282
- Testing
- physical activity, 2 x 30 minutes/day
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hillerod Hospital, Denmark
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Stroke, Acute Ischemic
Mechanical Thrombectomy of Medium Sized Vessels "M2 of MCA".
Mechanical thrombectomy recently has revolutionized the treatment of stroke. Trials have demonstrated the superiority of mechanical thrombectomy in large vessel occlusions, such as in the intracranialinternal carotid artery and…
- Trial name
- NCT05091320
- Testing
- Mechanical thrombectomy, medical treatment
- Volunteers
- 60 people
- Sponsor
- Assiut University
Contrast-Associated Acute Kidney Injury
Contrast-Associated Nephropathy Risk Evaluation in Acute Ischemic Stroke After Endovascular Thrombectomy
The CAN-REST study is a multicenter, observational, and retrospective study aimed at evaluating the incidence and risk factors of contrast-associated acute kidney injury (CA-AKI) in patients with acute ischemic stroke (AIS) who…
- Trial name
- CAN-REST (NCT06596603)
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- Niguarda Hospital
Acute Ischemic Stroke
Clinical Comprehensive Evaluation of Neuroprotective Drugs for Acute Ischemic Stroke
This study conducted a comprehensive evaluation of commonly used neuroprotective agents in acute ischemic stroke, assessing their real-world value across six dimensions: safety, efficacy, cost-effectiveness, innovativeness…
- Trial name
- Ischemic strok (NCT07260760)
- Volunteers
- 600 people
- Sponsor
- Qianfoshan Hospital
Acute Ischemic Stroke
Citicoline in Ischemic Stroke
There is evidence that citicoline is the only neuroprotectant able to improve the functional status of the patients after an acute ischemic stroke.
- Trial name
- NCT05154903
- Testing
- Citicoline 500 MG
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
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