Clinical trials: Stroke, Acute, Ischemic
Dysphagia Following Cerebrovascular Accident
High Intensity Dysphagia Rehab for Acute Ischemic Stroke Patients
The purpose of this study is to determine a standardized protocol for swallowing therapy and this protocol's effects on recovery after a stroke
- Trial name
- NCT05970406
- Testing
- high intensity dysphagia therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Stroke
Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
The objective of this study is to find out if Chinese Acute Ischaemic Stroke (AIS) patients older than 80 years benefit from intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) treatment within 4.5 hours of symptom…
- Trial name
- NCT05401149
- Testing
- rt-PA
- Where
- China
- Volunteers
- 3,058 people
- Sponsor
- Boehringer Ingelheim
Cardiovascular Disease
Genotype Guided Comparison of Clopidogrel and Prasugrel Outcomes Study
The primary objective of this trial is to demonstrate the non-inferiority of clopidogrel compared to prasugrel over 6 months in cardiovascular disease patients when the clopidogrel cohort is limited to the estimated 70% of the…
- Trial name
- GeCCO (NCT00995514)
- Where
- United States
- Volunteers
- 4,471 people
- Sponsor
- Medco Health Solutions, Inc.
Ischemic Stroke
Targeted Temperature Management in Acute Ischemic Stroke
The goal of this interventional trial is to evaluate whether the CB240_Aurora medical device is effective for targeted temperature management in adult patients with acute ischemic stroke.
- Trial name
- TTM-STROKE (NCT07096687)
- Testing
- Targeted Temperature Management with CB240_Aurora, Standard of care Temperature treatment
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Azienda Usl di Bologna
Acute Ischemic Stroke, Large Infarct Core
Methylprednisolone Adjunctive to Endovascular Thrombectomy for Stroke
The efficacy and safety of methylprednisolone in acute ischemic stroke patients with large infarct cores (ASPECTS score < 6 or infarct volume ≥50 mL) due to anterior circulation large vessel occlusion have not been clearly…
- Trial name
- MIRACLE (NCT06360458)
- Testing
- Methylprednisolone sodium succinate
- Where
- 99 sites in China
- Volunteers
- 928 people
- Sponsor
- Wan-Jin Chen
Hypertension, Ischemic Stroke
Fimasartan Blood Pressure Lowering After Acute Stroke
This study evaluates the effectiveness of fimasartan-based antihypertensive treatment and prognosis in post-acute phase of ischemic stroke or transient ischemic attack patients.
- Conditions
- Hypertension, Ischemic Stroke, Transient Ischemic Attack
- Trial name
- FABULOUS (NCT03231293)
- Where
- 27 sites in South Korea
- Volunteers
- 1,035 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Stroke Acute
NanO2 in Large VessEL Occlusion Stroke (NOVEL)
This is a National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) clinical trial aiming to investigate a possible new treatment to limit damage to the brain caused by a stroke.
- Trial name
- NOVEL (NCT06821347)
- Testing
- NanO2TM, Sodium Chloride 0.9% Intravenous
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Greater Glasgow and Clyde
Stroke, Stroke, Acute
Associative Peripheral Stimulation for Reduction of Motor Impairment During Acute Period of Stroke Recovery
Associative Peripheral Stimulation (APS) is a non-invasive therapy intended for stroke rehabilitation involving transcutaneous electrical muscle stimulation paired with voluntary movement.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke, Hemorrhagic
- Trial name
- APS-PILOT (NCT06575140)
- Testing
- Associative Peripheral Stimulation (APS) 1.0, Peripheral Neuromuscular Stimulation
- Where
- 3 sites in Mexico
- Volunteers
- 20 people
- Sponsor
- Ahmed A. Rahim
Ischemic Stroke, Medium Vessel Occlusion
Intra-arterial Tenecteplase for Acute Medium Vessel Occlusion Stroke
The ANGEL-MeVO-TNK is a multicentered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. A total of 488 AIS patients (age ≥18 years) with acute MeVO-AIS (occlusion of the M2/M3, the A1/A2/A3, the…
- Conditions
- Ischemic Stroke, Medium Vessel Occlusion, Tenecteplase, Endovascular Treatment
- Trial name
- ANGEL-MeVO-TNK (NCT07357987)
- Testing
- Intra-arterial Tenecteplase, standard medical management
- Where
- China
- Volunteers
- 488 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Stroke Acute
Research on the Effectiveness of Neurorehabilitation After Stroke
This clinical trial aims to investigate the effectiveness of a novel neurorehabilitation technology for treating stroke in adults.
- Conditions
- Stroke, Stroke Acute, Stroke with Hemiparesis, Stroke, Acute
- Trial name
- NCT06753006
- Testing
- Neurorehabilitation simulator, Standard course
- Where
- Russia
- Volunteers
- 44 people
- Sponsor
- Neurotechnika
Ischemic Stroke
Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction
The present study is designed to confirm the therapeutic effects of heat-clearing and blood-activating Chinese medicinal components in treatment of Acute Cerebral Infarction (ACI) and to investigate the therapeutic mechanisms of…
- Trial name
- NCT02544087
- Testing
- Ixeris of sonchifolia Hance, Panax notoginseng saponins, Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Yunling Zhang
Acute Ischemic Stroke
Single Arm Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System
The objective of the study is to evaluate the safety and effectiveness of the Route 92 Medical Monopoint Reperfusion System with the Hi Point 88 and HiPoint 70 Reperfusion Catheters when used to aspirate emboli in acute ischemic…
- Trial name
- SUMMITNZ (NCT05429658)
- Testing
- Thrombectomy
- Where
- 2 sites in New Zealand
- Volunteers
- 66 people
- Sponsor
- Route 92 Medical, Inc.
Acute Ischemic Stroke
A Research of Application of the New Model of Standardized Secondary Prevention of Stroke
To promote the application of the standardized secondary prevention of stroke in primary hospitals,and further reduce the recurrence rate, disability rate, and socioeconomic burden in China, the investigators aim to popularize…
- Trial name
- NCT05757635
- Volunteers
- 5,000 people
- Sponsor
- Peking Union Medical College Hospital
Acute Ischemia
REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke patiEnts
The main objective is to evaluate the efficacy of IV administration of the P2Y12 inhibitor (cangrelor) in addition to mecanich thrombectomy and WMD versus mecanich thrombectomy and WMD alone on the functional prognosis at 3…
- Trial name
- REPERFUSE (NCT04667078)
- Testing
- Cangrelor, best medical management
- Where
- 13 sites in France
- Volunteers
- 368 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Ischemic Stroke
Adjunctive Use of Intra-Arterial TNK and Albumin Following Thrombectomy
The purpose of this study is to investigate the feasibility and efficacy of intra-arterial TNK and albumin for patients with acute ischemic stroke after successful thrombectomy and whether there is a synergistic effect between…
- Trial name
- NCT06113848
- Testing
- Intra-Arterial TNK and Albumin, Intra-Arterial TNK, Intra-Arterial Albumin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tianjin Huanhu Hospital
Stroke
Ketamine for Thrombolysis in Acute Ischemic Stroke
KETA trial is a nonprofit, double-blind, randomized, controlled pilot trial with aiming to determine if co-administration of ketamine with recombinant of tissue type plasminogen activator (tPA) for thrombolysis in acute ischemic…
- Trial name
- KETA (NCT02258204)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Stroke
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis- (ATTEST)
A pilot evaluation of tenecteplase compared to alteplase in acute ischaemic stroke patients currently eligible for intravenous alteplase treatment in a prospective, randomised, blinded outcome evaluation clinical trial using…
- Trial name
- ATTEST (NCT01472926)
- Testing
- Tenecteplase, alteplase
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- NHS Greater Glasgow and Clyde
Stroke, Acute
Exercise and RIC and TCD
The first week after a stroke is a particularly important time, as improving blood flow may limit secondary ischaemic damage to the brain and help reduce the overall burden neurological injury and future disability.
- Trial name
- NCT03968068
- Testing
- Exercise Procedure, Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Acute Ischemic Stroke
Urokinase for Thrombolysis in Acute Ischemic Stroke
According to the Chinese Guidelines for the Diagnosis and Treatment of Ischemic Stroke, intravenous thrombolysis with urokinase, administered at doses of 1-1.5 million IU within 6 hours of symptom onset, has been shown to be both…
- Trial name
- NCT07047326
- Testing
- Urokinase thrombolysis
- Where
- 2 sites in China
- Volunteers
- 24 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke, Vessel Occlusion
REal-World Analyses of Stroke - Thrombus Occlusion REtrieval
To collect real-world evidence allowing assessment of functional, imaging, and safety outcomes of MicroVention market-released acute ischemic stroke devices when used at the direction of the treating physician.
- Conditions
- Acute Ischemic Stroke, Vessel Occlusion, Stroke, Ischemic
- Trial name
- "RESTORE" (NCT04451525)
- Testing
- MicroVention Mechanical Thrombectomy Devices as first-line treatment
- Where
- 37 sites in United States
- Volunteers
- 710 people
- Sponsor
- Microvention-Terumo, Inc.
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