Clinical trials: Stroke, Acute, open to volunteers
Acute Ischemic Stroke
Evaluation of Acute Endovascular Treatment in Symptomatic Isolated Cervical Internal Carotid Artery Occlusion (ETICA)
Our main hypothesis is that acute EVT associated with best medical treatment is superior to best medical treatment alone, for improving clinical outcomes at 90 days, in patients with mild or severe acute ischemique stroke and…
- Trial name
- ETICA (NCT05832762)
- Testing
- Endovascular treatment (EVT) + Best medical treatment (BMT), Best medical treatment (BMT)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Acute Ischemic Stroke
Phase III Clinical Trial of SHPL-49 Injection in the Treatment of Acute Ischemic Stroke
This study is designed to determine the efficacy and safety of SHPL-49 intravenous infusion in acute ischemic stroke patients.
- Trial name
- SAIL (NCT07241520)
- Testing
- SHPL-49 Injection
- Where
- China
- Volunteers
- 1,096 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Acute Ischemic Stroke
Effectiveness of Ginkgo Diterpene Lactone Meglumine in Acute Ischemic Stroke
The primary purpose of this study is to investigate the effectiveness of Ginkgo Diterpene Lactone Meglumine (GDLM) for patients with acute ischemic stroke (AIS) in real-world settings.
- Trial name
- PIONEER (NCT06861426)
- Testing
- Ginkgo Diterpene Lactone Meglumine
- Where
- 10 sites in China
- Volunteers
- 4,460 people
- Sponsor
- Ying Gao
Stroke, Acute, Stroke, Ischemic
HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN)
This study aims to address the existing clinical challenges by introducing high-resolution magnetic resonance vessel wall imaging (HR-MRI), an advanced imaging technology, to achieve precise etiological classification in patients…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Cerebral Infarction
- Trial name
- NCT07379190
- Testing
- Tirofiban, dual antiplatelet therapy
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Weifang Medical University
Intracerebral Hemorrhage, Nontraumatic Intracerebral Hemorrhage
Detection of an Endovascular Treatment Target in Patients With an Acute, Spontaneous Intracerebral Hemorrhage
This study is to determine if a treatment target for a potential endovascular therapy exists in patients with an acute, spontaneous (non-traumatic) ICH.
- Trial name
- HemEXPLO (NCT05504941)
- Testing
- Diagnostic, cerebral Digital Subtraction Angiography (DSA)
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University Hospital, Basel, Switzerland
Brain Ischemia
Informative of Surface Electromyography and Prognostic Factors in Assessing the Recovery of Balance and Gait After Stroke
The aim of the biomedical research is to determine the informativeness and prognostic factors of surface electromyography by assessing the probability of recovery of balance and gait parameters in the second stage of…
- Trial name
- NCT04981184
- Testing
- Gait and balance measurement
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Lithuanian University of Health Sciences
Acute Hemorrhagic Stroke
Multimodal Computed Tomography in Patients With Acute Hemorrhagic Stroke
Acute hemorrhagic stroke is a series of neurosurgical diseases characterized by bleeding with high morbidity and mortality. It accounts for about 20% of all strokes worldwide and mainly includes subtypes such as intracerebral…
- Trial name
- MCTAHS (NCT06061185)
- Testing
- Multimodal CT
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Xiaolin Chen, MD
Dysphagia, Stroke
Investigation of the Effect of Neuromuscular Electrical Stimulation Techniques on Suprahyoid Muscles and Swallowing Function in Acute Hemiparetic Stroke Patients
This randomized controlled trial aims to investigate the effects of sensory, motor, and modified combined neuromuscular electrical stimulation (NMES) protocols on swallowing function in patients with acute stroke-related…
- Conditions
- Dysphagia, Stroke, Hemiparesis
- Trial name
- NMESWAL (NCT07445204)
- Testing
- Conventional Swallowing Therapy, Vitalstim-Sensory NMES, Vitalstim-Motor NMES
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Arel University
Carotid Artery Stenosis, Acute Ischemic Stroke
Acute Stroke of CArotid Artery Bifurcation Origin Treated With Use oF the MicronEt-covered CGUARD (SAFEGUARD-STROKE)
Prospective, single-center, clinical registry of patients with acute stroke of carotid artery bifurcation origin undergoing endovascular treatment using the Micronet-covered CGUARD Stent to seal the culprit lesion under proximal…
- Trial name
- NCT05195658
- Testing
- Thrombectomy and Stenting under neuroprotection
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- John Paul II Hospital, Krakow
Acute Ischemic Stroke
Urokinase for Thrombolysis in Acute Ischemic Stroke
According to the Chinese Guidelines for the Diagnosis and Treatment of Ischemic Stroke, intravenous thrombolysis with urokinase, administered at doses of 1-1.5 million IU within 6 hours of symptom onset, has been shown to be both…
- Trial name
- NCT07047326
- Testing
- Urokinase thrombolysis
- Where
- 2 sites in China
- Volunteers
- 24 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke
The DOWN-SUITE study is multicenter, randomised, controlled, open-label clinical trial with blinded outcome assessment comparing collateral status in patients with acute ischemic stroke treated with an in-hospital application of…
- Trial name
- DOWN-SUITE (NCT06297863)
- Testing
- HEAD DOWN TILT -10° to -15°
- Where
- 6 sites in Italy
- Volunteers
- 118 people
- Sponsor
- University of Milano Bicocca
Acute Basilar Artery Occlusion, Posterior Circulation Large Infarct
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute basilar artery occlusion with…
- Trial name
- NCT06924996
- Testing
- Endovascular Thrombectomy (EVT)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Feng Gao
Stroke, Acute Ischemic
Endovascular Treatment for eXtra-Large Ischemic Stroke
The role of endovascular thrombectomy in patients with extra-large ischemic burden is still unclear. The XL STROKE-2 randomized trial is aiming to investigate the efficacy and safety of mechanical thrombectomy in acute…
- Trial name
- XL STROKE-2 (NCT06388148)
- Testing
- Medical management, Endovascular thrombectomy
- Where
- 2 sites in China
- Volunteers
- 286 people
- Sponsor
- Zhongming Qiu
Ischemic Stroke, CYP2C19 Polymorphism
Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke
The goal of this observational study is to use a genetic test to help doctors prescribe the most effective medications after a patient has a stroke. One type of stroke is caused by a blood clot in brain vessels.
- Trial name
- ORCA-AIS (NCT06292117)
- Testing
- CYP2C19 Genotype
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Virginia
Stroke, Acute Ischemic Stroke
Study on Anti-Thrombotic Regimens for Secondary Prevention in Ischemic Stroke Patients With Possible Benefit From Anticoagulation Therapy
To screen ischemic stroke patients likely to benefit from anticoagulation and compare the effectiveness and safety of anticoagulation versus antiplatelet therapy in preventing recurrent ischemic stroke within 3 months.
- Trial name
- NCT07746882
- Testing
- Rivaroxaban, or Edoxaban , or Apixaban , or Dabigatran, Aspirin
- Volunteers
- 680 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dysphagia
Non-standardized vs. Standardized Screening for Dysphagia
The purpose of this study is to compare two different screening tests for detecting dysphagia (difficulty swallowing) as well as the risk for aspiration (silent swallowing of liquids/solids into the lungs) in patients after an…
- Trial name
- NCT05603897
- Testing
- Mann Assessment of Swallowing Ability (MASA) (dysphagia screening tool), Non-standardized clinical swallow evaluation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Stroke, Acute Ischemic Stroke
Intravenous Thrombosis and Patients with Prior Ischemic Stroke Within 3 Months
The primary hypothesis being tested in this trial is that ischemic stroke patients with prior ischemic stroke within 3 months will have improved clinical outcomes when given intravenous thrombolysis compared to standard care.
- Trial name
- NCT06841978
- Testing
- Intravenous Thrombolysis
- Volunteers
- 306 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Brain-computer Interface (BCI)-Guided Upper Limb Neurorehabilitation for Acute Stroke With the recoveriX System
Stroke is a leading cause of neurological disability and upper limb impairment. While conventional rehabilitation options exist, brain-computer interface (BCI)-based neurorehabilitation has emerged as a promising approach that…
- Trial name
- NCT07858006
- Testing
- BCI-Based Neurorehabilitation with Functional Electrical Stimulation (recoveriX)
- Volunteers
- 12 people
- Sponsor
- Tan Tock Seng Hospital
Stroke, Acute Ischemic
Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke
Stroke is a leading cause of disability and mortality worldwide. Despite the clinical benefit of mechanical thrombectomy, 1 out of 2 patients treated are functionally independent at 90 days.
- Trial name
- IA-SUCCESS (NCT06768138)
- Testing
- Intra-arterial infusion of Alteplase
- Where
- France
- Volunteers
- 626 people
- Sponsor
- Central Hospital, Nancy, France
Acute Ischemic Stroke From Large Vessel Occlusion, Endovascular Thrombectomy
Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO
The purpose of this study is to determine the efficacy and safety of plasma adsorption for patients of acute ischemic stroke who underwent endovascular thrombectomy due to large vessel occlusion of anterior circulation.
- Trial name
- PROMOTE-EVT (NCT07042490)
- Testing
- Plasma adsorption, Endovascular Thrombectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Yang