Clinical trials: Stroke, Acute
Acute Ischemic Stroke
Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well
SELECT LATE trial aims to evaluate if addition of endovascular thrombectomy to medical management in patients presenting with acute ischemic stroke and a proximal large vessel occlusion in the anterior circulation between 24 and…
- Trial name
- SELECT LATE (NCT07115940)
- Testing
- Endovascular Thrombectomy, Medical Management
- Where
- 6 sites in United States
- Volunteers
- 408 people
- Sponsor
- Amrou Sarraj
Acute Ischemic Stroke
Predictive Study of Serum Endocan for Hemorrhagic Transformation After Reperfusion Therapies in Acute Ischemic Stroke
Stroke is the second largest cause of death globally after ischemic heart disease.Of the total number of prevalent strokes, 84.4% are ischemic.
- Trial name
- NCT05228080
- Testing
- enzyme-linked immunosorbent assay(ELISA)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke
Blood Biomarkers to Predict the Prognosis of a Stroke Patient Undergoing Mechanical Thrombectomy
The goal of this observational study is to evaluate the accuracy of a panel of blood biomarkers and clinical variables in predicting the prognosis of stroke patients treated by mechanical thrombectomy, specifically to predict…
- Trial name
- TROMBOPOCT (NCT06467396)
- Testing
- Large Vessel Occlusion Biomarkers Test
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Acute Stroke
Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke
Ischemic stroke, which is due to the occlusion of a cerebral blood vessel, comprises nearly 80-90% of all strokes. Currently, reperfusion of the salvageable tissue via thrombolytic drug or endovascular treatment is the most…
- Trial name
- REVISE-2 (NCT03045055)
- Testing
- Remote ischemic conditioning., Endovascular treatment.
- Volunteers
- 180 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Combined Use of Contact Aspiration and the Stent Retriever Technique Versus Stent Retriever Alone for Recanalisation in Acute Cerebral Infarction
Mechanical thrombectomy (MT) with a stent retriever (SR) device is now the standard intervention in ischemic stroke with large vessel occlusion. Favorable outcome is strongly associated with the successful reperfusion status.
- Trial name
- ASTER2 (NCT03290885)
- Testing
- Combined contact aspiration/Stent Retriever Technique, Stent retriever technique
- Where
- 11 sites in France
- Volunteers
- 408 people
- Sponsor
- Hopital Foch
Stroke, Acute Cerebral Infarction
Perfusion Imaging Evaluation for Ischemic Stroke on 6-24 Hours Undergoing Endovascular Thrombectomy
This study aims to evaluate the hypothesis that thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days as compared to medical management alone in…
- Trial name
- PESET (NCT03502408)
- Testing
- Endovascular Thrombectomy
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation, Stroke, Acute
Characterization and Prediction of Atrial Fibrillation-caused Adverse Events After Hospital Discharge for Cardiac Surgery
The purpose of the research is to identify the frequency and severity of adverse events related to atrial fibrillation that occur after discharge from hospital where the patient underwent cardiac surgery.
- Conditions
- Atrial Fibrillation, Stroke, Acute, Death
- Trial name
- MATRICeS (NCT03466125)
- Testing
- Cardiac surgery
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Brigham and Women's Hospital
Acute Ischemic Stroke
Intra-arterial Albumin in Acute Ischemic Stroke After Endovascular Treatment for
Stroke is an acute focal injury of the central nervous system caused by cerebral vessels. One in every four people is affected by stroke at different times in life.
- Trial name
- NCT06172387
- Testing
- intra-arterial infusion albumin, mechanical thrombectomy and a standard clinical therapy
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke (AIS)
Study of the Safety and Neuroprotective Capacity of Scp776 in Acute Ischemic Stroke
A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study of the Safety and Neuroprotective Capacity of Scp776 in Subjects Undergoing Endovascular Thrombectomy for Acute Ischemic Stroke
- Trial name
- ARPEGGIO (NCT05585606)
- Testing
- scp776 (1.9 mg/kg), scp776 (3.8 mg/kg), scp776 (4.8 mg/kg)
- Where
- 22 sites in United States
- Volunteers
- 120 people
- Sponsor
- Silver Creek Pharmaceuticals
Acute Ischemic Stroke Due to Intracranial Large Artery Occlusion
First-pass Recanalization With EmboTrap II in Acute Ischemic Stroke (FREE-AIS)
This study is a prospective, open-label, multi-center, registry study, designed to to documents that EmboTrap II usage as a thrombectomy device for emergency large vessel occlusion (ELVO) in terms of the rate of First Pass…
- Trial name
- NCT04310306
- Testing
- Thrombectomy using EmboTrap II
- Where
- South Korea
- Volunteers
- 310 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke AIS
The STem Cell-derived Extracellular Vesicle Therapy In Acute Ischemic Stroke (STEVIA)
This is a multicenter open-label, single-arm, dose escalation phase I clinical trial to evaluate the safety and tolerability of SNE-101 in patients with acute ischemic stroke
- Trial name
- STEVIA (NCT06995625)
- Testing
- SNE-101
- Where
- 3 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- S&Ebio Co. Ltd.
Acute Ischemic Stroke
Bloodletting Puncture in the Treatment of Acute Ischemic Stroke
The bloodletting puncture is an external treatment for acute ischemic stroke by releasing an appropriate amount of blood with a three-edged needle at specific points on the patient's body.
- Trial name
- NCT05266326
- Testing
- Western medicine conventional treatment +Bloodletting puncture, Western medicine conventional treatment
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Chongqing Traditional Chinese Medicine Hospital
Brain Ischemia, Acute Stroke
Heart and Ischemic STrOke Relationship studY
Although cardio-embolic etiology of ischemic stroke (IS) is largely respected, there is still no clear recommendation for routine complex cardiological examination in all IS patients.
- Conditions
- Brain Ischemia, Acute Stroke, Heart Diseases
- Trial name
- HISTORY (NCT01541163)
- Where
- Czechia
- Volunteers
- 500 people
- Sponsor
- University Hospital Olomouc
Stroke, Acute
Evaluation of Direct Transfer to Angiography Suite vs. Computed Tomography Suite in Endovascular Treatment: Randomized Clinical Trial (ANGIOCAT)
To evaluate the hypothesis that an ultra-fast triage with one-stop in angiography suite based on cone-beam CT compared to traditional protocol offers a better outcome in the distribution of the modified Rankin Scale scores at 90…
- Trial name
- ANGIOCAT (NCT04001738)
- Testing
- Direct Transfer to Angio Suite
- Where
- Spain
- Volunteers
- 174 people
- Sponsor
- Hospital Vall d'Hebron
Acute Stroke
Efficacy of Whole Extract of Licorice in Neurological Improvement of Patients After Acute Ischemic Stroke
Stroke is one of the most important causes of mortality and disability both in developed and developing countries. The only food and drug administration (FDA) approved therapy for acute stroke is recombinant tissue plasminogen…
- Trial name
- NCT02473458
- Testing
- Licorice whole extract
- Where
- Iran
- Volunteers
- 75 people
- Sponsor
- Shiraz University of Medical Sciences
Ischemic Stroke
Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy
Endovascular thrombectomy (EVT) is a procedure that improves recovery for people who suffer from a stroke by removing blood clots from large blood vessels in the brain.
- Trial name
- LEAST (NCT07511543)
- Testing
- Semaglutide
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Stroke, Acute, Dysphagia
Impact of Physical Therapy of Dysphagia on Preventing Pneumonia in Acute Stroke Patients
To investigate the impact of physical therapy intervention of dysphagia on preventing pneumonia in acute stroke patients
- Conditions
- Stroke, Acute, Dysphagia, Pneumonia
- Trial name
- NCT06010940
- Testing
- Dietary supplement, Physical therapy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Acute Ischemic Stroke
DAISe 1 Feasibility Study to Evaluate the DAISe Thrombectomy System for Acute Ischemic Stroke
The study is a prospective, multi-center, single arm, feasibility study that will enroll a maximum of 36 subjects. The maximum enrollment is 10 subjects per site. A maximum of 6 investigational centers in Europe will participate.
- Trial name
- NCT05139147
- Testing
- DAISe Thrombectomy System
- Where
- 6 sites in France
- Volunteers
- 16 people
- Sponsor
- MIVI Neuroscience, Inc.
Stroke
Prehospital Transcranial Duplex in Patients With Acute Stroke
The aim of the study is to investigate patients with acute stroke prehospital with transcranial duplex ultrasound to detect an infarct of the middle cerebral artery.
- Trial name
- NCT01069276
- Testing
- No intervention in this study
- Where
- Germany
- Sponsor
- Johannes Gutenberg University Mainz
Stroke, Acute
Exercise and RIC and TCD
The first week after a stroke is a particularly important time, as improving blood flow may limit secondary ischaemic damage to the brain and help reduce the overall burden neurological injury and future disability.
- Trial name
- NCT03968068
- Testing
- Exercise Procedure, Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust