Clinical trials: Stroke, Acute
Stroke, Acute
Protective Effects of Normobaric Hyperoxia on Blood Brain Barrier in Patients With Acute Ischemic Stroke
The purpose of this study is to find out a serum marker for the evaluation of blood brain barrier damage based on animal experiments and investigate the effect of NBO（Normobaric hyperoxia）on blood brain barrier in the acute…
- Trial name
- NCT02974283
- Testing
- Normobaric oxygen therapy
- Volunteers
- 40 people
- Sponsor
- Capital Medical University
Ischemic Stroke
The Norwegian Sonothrombolysis in Acute Stroke Study Part 2
BACKGROUND: Thrombolytic drugs may dissolve blood vessel clots in acute ischemic stroke. The overall benefit of intravenous thrombolysis is substantial, but up to 2/3 of patients with large clots may not achieve re-opening of the…
- Trial name
- NOR-SASS 2 (NCT01949961)
- Testing
- Ultrasound
- Where
- Norway
- Volunteers
- 59 people
- Sponsor
- Haukeland University Hospital
Stroke
Edaravone Dexborneol Combining With Mechanical Thrombectomy in the Treatment of Acute Ischemic Stroke
Edaravone dexborneol, comprised of 2 active ingredients, edaravone and (+)-borneol, has been developed as a novel neuroprotective agent with synergistic effects of antioxidant and anti-inflammatory in animal models.
- Trial name
- NCT05121883
- Testing
- Edaravone Dexborneol
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke, Anticoagulant Adverse Reaction
Evaluataion of NOAC Levels in Acute Stroke
Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended over warfarin in preventing stroke and thromboembolism among patients with atrial fibrillation (AF) in several guidelines.
- Trial name
- NCT06144866
- Testing
- Dabigatran, rivaroxaban, apixaban, edoxaban
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Acute Ischemic Stroke, Artificial Intelligence (AI)
AI-Driven CTA Reconstruction for Intracranial LVO
Acute ischemic stroke (AIS) caused by intracranial large vessel occlusion (LVO) in the anterior circulation significantly contributes to stroke-related disability and mortality.
- Conditions
- Acute Ischemic Stroke, Artificial Intelligence (AI), Endovascular Thrombectomy, CT Angiography
- Trial name
- SMART-AI (NCT06645405)
- Testing
- AI algorithm
- Where
- 2 sites in China
- Volunteers
- 174 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Stroke, Stroke, Acute
Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology
The purpose of this study is to assess the ability of the Fluids Monitor to detect hemispheric bioimpedance asymmetry associated with acute brain pathology in patients presenting with suspected Acute Ischemic Stroke (AIS).
- Conditions
- Stroke, Stroke, Acute, Ischemic Stroke, Hemorrhage
- Trial name
- VITAL (NCT03148340)
- Testing
- VIPS Monitoring
- Where
- 5 sites in United States
- Volunteers
- 287 people
- Sponsor
- Cerebrotech Medical Systems, Inc.
Acute Ischemic Stroke
Qingre Huatan Formula for the Prevention of Early Neurological Deterioration in Acute Ischemic Stroke
The purpose of this study is to assess the effectiveness and safety of Qingre Huatan formula versus placebo on preventing early neurological deterioration in patients with acute ischemic stroke within 48 hours after onset.
- Trial name
- QUIET (NCT06857487)
- Testing
- Qingre Huatan Formula, Guidelines-based standard care
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Dongzhimen Hospital, Beijing
Acute Ischemic Stroke
Registry of Acute Ischemic Stroke With Large- or Medium-vessel Occlusion
This study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.
- Trial name
- LOMEVO (NCT05779215)
- Testing
- Visit at D90
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Optimizing Door-to-reperfusion Times of One-stop Management in Acute Ischemic Stroke
Time is one of the most important in the decision of treatment of acute ischemic stroke. The optimal One-stop management from admission to recanalization associated with reduction of in-hospital times.
- Trial name
- ORETOM (NCT05644938)
- Testing
- Standard workflow, One-stop
- Where
- Vietnam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Stroke
Far Infrared Irradiation for Stroke Rehabilitation
A stroke is a sudden loss of brain function. It is caused by the interruption of flow of blood to the brain (ischemic stroke) or the rupture of blood vessels in the brain (hemorrhagic stroke).
- Trial name
- NCT00675155
- Testing
- Far Infrared Radiation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- GAAD Medical Research Institute Inc.
Acute Stroke, Ischemic Stroke, Acute
Rescue Carotid Stenting in Tandem Occlusions: 4-year Experience From a Comprehensive Stroke Centre
The rescue carotid stenting has recently been an additional treatment followed by mechanical thrombectomy in tandem occlusions of the anterior circulation.
- Trial name
- NCT06397638
- Testing
- Rescue carotid stenting
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- Can Tho Stroke International Services Hospital
Acute Stroke Patients Requiring Invasive Mechanical Ventilation
Stroke Prognosis in Intensive CarE
The S.P.I.C.E registry is an investigator-initiated prospective multicenter cohort study which will be conducted in 35 ICUS in the Paris area.The aim of the study is to determine the trajectory of acute stroke patients requiring…
- Trial name
- SPICE (NCT03335995)
- Where
- France
- Volunteers
- 364 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute Stroke
Evaluation of Neurosteer System in Stroke Patients
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through a series of EEG recordings during their…
- Trial name
- NCT05524415
- Testing
- Neurosteer EEG recorder
- Where
- Israel
- Sponsor
- Neurosteer Ltd.
Acute Ischemic Stroke, Cerebral Edema
The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers
This is a single-center, randomized, double-blind, placebo-controlled Phase I clinical study to evaluate the tolerability, safety, and pharmacokinetic characteristics of SIM1910-09 for injection after single/multiple dosing in…
- Trial name
- NCT05200728
- Testing
- SIM1910-09
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Acute Ischemic Stroke
An Application Provides Temperature-related Health Risk Warnings and Protective Recommendations on Stroke
This study applied an application to provide early warnings and advice for stroke patients and explored the impact of this intervention on reducing the risk of stroke recurrence
- Trial name
- NCT07097428
- Testing
- Temperature health risk early warning
- Volunteers
- 5,092 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Malnutrition
Nutritional Therapy for Stroke Patients
Prospective, short-term studies in patients admitted for acute stroke have shown an increased risk of infections, bedsores, impaired functional outcome, slower rate of recovery, poorer rehabilitation potential and higher…
- Conditions
- Stroke, Malnutrition, Weight Loss, Dysphagia
- Trial name
- NCT00163007
- Testing
- Nutritional support
- Where
- Norway
- Volunteers
- 125 people
- Sponsor
- Ostfold Hospital Trust
Stroke, Acute, Gait, Spastic
Rhythmic Auditory Stimulation as Pre-Gait Training for Improving Balance and Weight Shifting in Rehabilitation Patients
The purpose of this study is to explore whether Rhythmic Auditory Stimulation (RAS) as pre-gait training can help improve balance, weight-shifting abilities, and overall gait performance in stroke patients undergoing…
- Conditions
- Stroke, Acute, Gait, Spastic, Attention Impaired
- Trial name
- NCT06995092
- Testing
- Music therapy, Standard physiotherapy program
- Where
- Malaysia
- Volunteers
- 27 people
- Sponsor
- University of Malaya
Acute Coronary Syndrome, Stroke
Florbetaben for Imaging of Vascular Amyloid
The Primary Objective is to determine if a new nuclear tracer (named 18F-Florbetaben) used with nuclear imaging (PET imaging) can detect inflamed plaque in patients with recent ACS or stroke/TIA.
- Conditions
- Acute Coronary Syndrome, Stroke, Transient Ischemic Attack, Atherosclerosis of Artery
- Trial name
- FERMATA (NCT06091319)
- Testing
- [18F]-Florbetaben PET and CT imaging
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Stroke, Stroke, Acute
Achieving Meaningful Clinical Benchmarks With Ekso Gait Training During Acute Stroke Inpatient Rehabilitation.
The Ekso (Ekso Bionics) is a wearable exoskeleton that provides robotic support and walking assistance for patients with lower extremity paralysis.
- Conditions
- Stroke, Stroke, Acute, Cerebrovascular Accident, Cerebrovascular Accident, Acute
- Trial name
- NCT05241457
- Testing
- Ekso gait training, Standard physical therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sunnyview Rehabilitation Hospital
Multiple Sclerosis
The Effectiveness of Locomotor Therapy Using Robot-Driven Gait Orthosis System in Multiple Sclerosis Patients
Objective: To evaluate the efficacy of robot-assisted gait training (RAGT) in MS patients with severe walking disabilities (Expanded Disability Status Scale [EDSS] 5.5-7) as compared to regular physiotherapy.
- Trial name
- NCT00843128
- Testing
- robot-assisted gait training (RAGT), conventional walking training (CWT)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization