Clinical trials: Stroke, Cerebral
Stroke, Spasticity, Muscle
Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients
This study evaluates the effects of an isokinetic fatigue protocol of the quadriceps on the amount of co-contractions of this last with the hamstrings during a maximal isometric flexion movement in hemiparetic stroke patients.
- Conditions
- Stroke, Spasticity, Muscle, Muscle Fatigue, Gait, Hemiplegic
- Trial name
- COCON (NCT03342820)
- Testing
- Muscle fatigue
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Stroke
Reaching in Stroke 3rd Phase
The project targets stroke survivors to investigate the effect of augmented feedback (using robotic force cues and visual feedback) and rewards (game scores), on their upper limb reaching patterns and trunk compensatory movements
- Trial name
- RISP3 (NCT02912923)
- Testing
- Visual + Force Feedback, Visual + Force + Game Scores Feedback
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- University of British Columbia
Stroke
Stroke Self-Management: Effect on Function and Stroke Specific Quality of Life
The experience of a stroke event may result in a disruption to the survivor's daily life. Patients with stroke have reported fears of permanent disability and major concerns over their ability to recover and be productive and…
- Trial name
- NCT01507688
- Testing
- Stroke Self-Management
- Where
- 2 sites in United States
- Volunteers
- 258 people
- Sponsor
- VA Office of Research and Development
Stroke
Safety of Transcranial Direct Current Stimulation in the Subacute Phase After Stroke
Stroke is the second cause of death worldwide and represented the first cause of death in Brazil between 2006 and 2010. Most patients survive, and there is a need to develop cost-effective rehabilitation strategies to decrease…
- Trial name
- NEUROSTIM (NCT02455427)
- Testing
- Active tDCS, Physical Therapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital Israelita Albert Einstein
Stroke
Validation of a Spasticity Measurement Tool
The objective of this project is to investigate the validity of a handheld spasticity measurement tool against standard clinical measurements of spasticity.
- Trial name
- NCT05374174
- Testing
- Tardieu Scale for Spasticity
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Strokes Thrombotic
Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation
Approximately 50% of patients have persistent motor disability following stroke. Current treatment approaches with conventional physiotherapy have limited efficacy.
- Trial name
- NCT03555474
- Testing
- Theta burst stimulation, Functional Electrical Stimulation, Physiotherapy
- Volunteers
- 60 people
- Sponsor
- Sree Chitra Tirunal Institute for Medical Sciences & Technology
Acute Ischemic Stroke
Safety and Tolerability of Adjunctive TBO-309 in Reperfusion for Stroke
STARS is a prospective, multicentre, open-label, dose escalation, Phase IIa study to assess the safety and tolerability of TBO-309, an adjuvant antiplatelet therapy, in patients with AIS.
- Trial name
- STARS (NCT05363397)
- Testing
- TBO-309
- Where
- 7 sites in Australia
- Volunteers
- 80 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Chronic Stroke
Universal Exercise Unit Therapy With Sling Exercise Therapy on Lower Limb Kinematics in Chronic Stroke Patients
Stroke occurred when blood supply to brain or a part of brain is disturbed due to clot (ischaemic stroke) or due rupture of small vessels (hemorrhagic stroke) in brain and causes bleeding in brain cells.
- Trial name
- NCT05033873
- Testing
- Universal Exercise Unit Therapy (UEU), Sling Exercise Therapt (SET), Routine Physical Therapy / Control Group
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Riphah International University
Stroke, Spasticity
Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients
Spasticity, muscle weakness, abnormal gait pattern are co-morbidities commonly seen in stroke patients. They cause disabled condition of patients in activities of daily life and functional performance, and also accidental falls…
- Trial name
- NCT01817816
- Testing
- Botox_A, Botox_B
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Changhua Christian Hospital
Stroke Sequelae
Virtual Reality Versus Constraint-induced Movement on Hemiparesis in Cerebrovascular Event
The objective of this clinical trial is to measure the effect of Rehabilitation with Virtual Reality or Modified Constraint-Induced Movement Therapy on hemiparesis in patients with Cerebral Vascular Event.
- Trial name
- NCT05875116
- Testing
- Virtual reality, Modified constraint-induced movement therapy, Usual Physical and Occupational Therapy
- Where
- Mexico
- Volunteers
- 119 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Ischemic Stroke, Post-stroke Cognitive Impairment
Safety and Efficacy of ALZT-OP1a as Adjuvant Treatment in Subjects With Post-Ischemic Stroke Cognitive Impairment (PSCI)
This is a Phase II, randomized, double-blinded, placebo-controlled study for subjects with evidence of PSCI.
- Trial name
- NCT03202147
- Testing
- Cromolyn
- Sponsor
- AZTherapies, Inc.
Stroke
Gait Training in Post-Stroke Hemiparesis Hemiparesis
The focus of this study is to optimize the delivery of a combined strength and aerobic training regimen to individuals with post stroke hemiparesis and reduce overuse and inefficiencies associated with the nonparetic leg during…
- Trial name
- NCT04877249
- Testing
- Split-belt treadmill training
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Stroke, Gait, Spastic
Effectiveness and Safety of At-home Gait Rehabilitation Using Wearable Exoskeletal Robot
The goal of this clinical trial is to evaluate the effectiveness and safety of a home-based robotic-assisted gait rehabilitation service using a wearable exoskeletal robot for stroke patients.
- Conditions
- Stroke, Gait, Spastic, Gait, Hemiplegic
- Trial name
- NCT06543758
- Testing
- Wearable exoskeletal robot
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yonsei University
Stroke Patients
Application of the Triple Stimulation Technique to Patients With CNS Disorders Including Stroke
TST (Triple stimulation technique) helps to better quantify the proportion of motor units activated by transcranial magnetic stimulation.
- Trial name
- NCT02354248
- Testing
- Triple stimulation technique
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Stroke
The Effects of Elliptical Cross Training Bike for Stroke Patients
To investigate the effects of elliptical cross bike exercises combine conventional physical therapy on gait, postural control, balance, muscle tone, spasticity, quality of life, motor functioning, functional activity, and ADL in…
- Trial name
- NCT03528148
- Testing
- cycling, Physical therapy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- China Medical University Hospital
Ischemic Stroke, Intracerebral Haemorrhage
Head Position in Stroke Trial (HeadPoST)
This study is an investigator-initiated and conducted, international collaborative, regionally organised, multicentre, prospective, cluster randomised, crossover, blinded outcome assessment study to compare the effectiveness of…
- Trial name
- HeadPoST (NCT02162017)
- Testing
- The lying flat (0°) head position for 24 hours, The sitting-up (≥30°) head position for 24 hours
- Where
- Australia
- Volunteers
- 11,096 people
- Sponsor
- The George Institute
Stroke, Stomach Acidity
Gastrointestinal Decompression in Stroke
Acute severe ischemic stroke is a life-threatening subtype of stroke. Due to stress ulcer and gastric reflux in acute stage, patients with severe ischemic stroke are always complicated with stomach bleeding and pulmonary…
- Conditions
- Stroke, Stomach Acidity, Pulmonary Infection, Gastrointestinal Decompression
- Trial name
- EAGER-ASSIST (NCT06214091)
- Testing
- Gastrointestinal decompression, Control
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University General Hospital
Cardiovascular Diseases, Heart Diseases
Predictors of Cardiovascular Disease in the Elderly
To evaluate factors associated with cardiovascular morbidity and mortality in a cohort of 795 men and women aged 75 years or older at the time of a comprehensive examination conducted between 1984 and 1987.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00005460
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Stroke, Acute
Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-5
The trial is a multicentre, prospective, open-label, blinded endpoint (PROBE), phase 3, randomized controlled design. Patients with acute ischemic stroke due to basilar artery occlusion presenting within 24 hours will be…
- Trial name
- TRACE-5 (NCT06196320)
- Testing
- Tenecteplase, Best Practice (which may include intravenous Alteplase)
- Where
- 59 sites in China
- Volunteers
- 452 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Effectiveness of Shock Wave Therapy for Upper Limb Spasticity
Introduction: Shock wave therapy (SWT) has a potential interest to treat spasticity. However, the pathophysiology of this treatment remains unknown.
- Trial name
- NCT04316026
- Testing
- shock wave therapy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
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