Clinical trials: Stroke, Cerebral
Ischemic Stroke
Inflammatory faCtors AfteR acUte Ischemic Stroke
ICARUS is an interventional single-centre hospital-based cohort study in patients admitted to the stroke unit with an acute ischemic stroke.
- Trial name
- ICARUS (NCT04412187)
- Testing
- [18F]-GE-180 PET, 3T MRI, immune cell profiling in blood
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Martin Dichgans
Aquired Brain Injury, Stroke
Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study
Difficulties in understanding and managing emotions may hinder recovery, rehabilitation, and participation in everyday life after acquired brain injury (ABI).
- Conditions
- Aquired Brain Injury, Stroke, MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- NCT07852936
- Testing
- TAU + Group Therapy (EAET), Treatment as Usual (TAU)
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Ischemic Stroke
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis
The principle research question is: in patients with acute ischaemic stroke eligible for intravenous (IV) thrombolysis, is tenecteplase superior in efficacy to alteplase, based on functional outcome as assessed by modified Rankin…
- Trial name
- ATTEST2 (NCT02814409)
- Testing
- Intravenous recombinant tissue plasminogen activator (rtPA) Alteplase, Intravenous Tenecteplase
- Where
- United Kingdom
- Volunteers
- 1,858 people
- Sponsor
- NHS Greater Glasgow and Clyde
Acute Ischemic Stroke
Tenecteplase for Intravenous Stroke Thrombolysis in Recent DOAC Users
An investigator-initiated, multicenter, randomized, placebo-controlled, double-blind trial to determine the efficacy and safety of intravenous tenecteplase thrombolysis in acute ischemic stroke (AIS) patients with recent direct…
- Trial name
- PEARL-DOAC (NCT07092709)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- China
- Volunteers
- 912 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Balance Impairments in Stroke Patients
Can Lumbar Mulligan Mobilization Improve Gait, Balance, and Trunk Position Sense After Stroke?
Stroke is a pathology caused by disturbances in the brain's arterial circulation, leading to high morbidity rates. Individuals who experience a stroke often face neurological impairments such as motor, sensory, and cognitive…
- Trial name
- NCT06887114
- Testing
- Experimental Group (Mulligan Mobilization + Conventional Therapy), (Conventional Therapy Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gulhane School of Medicine
Ischemic Stroke, Alteplase Adverse Reaction
Predictors of AIS Unfavorable Outcomes
The investigators evaluated whether the characteristics of ischemic stroke patients, door-to-needle time, and stroke risk factors were predictive variables for unfavourable outcomes.
- Trial name
- NCT06058884
- Testing
- Alteplase
- Where
- Egypt
- Volunteers
- 592 people
- Sponsor
- Kafrelsheikh University
Stroke
Safety and Efficacy Study in Acute Ischaemic Stroke
A Phase II study to evaluate the safety and efficacy of five dose levels of study drug in acute ischaemic stroke
- Trial name
- VASST (NCT00144014)
- Testing
- V10153
- Where
- 28 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Vernalis (R&D) Ltd
Acute Ischemic Stroke
A Study to Evaluate the Effects of YM872 on Brain Function and Disability When Administered in Combination With Alteplase (Tissue Plasminogen Activator)
The purpose of this study is to determine if YM872 in combination with t-PA can reduce disability and brain damage from stroke. YM872 or placebo will be given as a continuous intravenous (iv) infusion for 24 hours.
- Trial name
- NCT00044057
- Testing
- YM872 (zonampanel), t-PA (alteplase)
- Where
- 118 sites in United States, Austria and 3 more
- Sponsor
- Astellas Pharma Inc
Pregnancy-associated or Puerperium-associated Acute Stroke
Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium
The objectives of this study are: (1) to describe the detailed clinical characteristics and prognosis of ASPP patients in order to explore the risk factors of ASPP, and to compare the short-term and long-term functional recovery…
- Trial name
- ASPP (NCT06527807)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Upper Limb Paresis
Thermal Stimulation for Stroke Patients
Sensory and/or motor deficits in upper limb following stroke often have negative impacts on their daily living. Thermal stimulation with hot and cold pack alternatively incorporated into conventional rehabilitation has been…
- Trial name
- TSSP (NCT01658293)
- Testing
- thermal stimulation, control group ergometer exercises
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Acute Ischemic Stroke
Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study designed to evaluate the efficacy of recombinant human tissue-type plasminogen activator variant (rhTNK-tPA) (0.25 mg/kg, maximum dose…
- Trial name
- TRACE-LATE (NCT07201688)
- Testing
- rhTNK-tPA
- Where
- China
- Volunteers
- 890 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Patent Foramen Ovale, Stroke
Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO)
The primary objective of the study is to determine whether the STARFlex® septal closure system will safely and effectively prevent a recurrent embolic stroke/transient ischemic attack (TIA) and mortality in patients with a PFO…
- Conditions
- Patent Foramen Ovale, Stroke, Ischemic Attack, Transient
- Trial name
- NCT00201461
- Testing
- STARFlex septal closure system, Best medical therapy
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- NMT Medical
Multiple Sclerosis, Stroke
PLasmatic Extracellular Vesicles AS Biomarkers of nEural Tissue Damage
Recently proposed central nervous system damage biomarkers detectable in biofluids, such as neurofilament light chain (NfL) have several limits, including a lack in specificity and a kinetic that does not allow them to be used as…
- Trial name
- PLEASE (NCT07769294)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Roberto Furlan
Stroke, Rehabilitation
Dynamic Individualized rTMS Based on fNIRS
Stroke patients do not respond well to the traditional repetitive transcranial magnetic stimulation (rTMS) strategy based on the competitive model.
- Conditions
- Stroke, Rehabilitation, Repetitive Transcranial Magnetic Stimulation, Functional Near-infrared Spectroscopy
- Trial name
- NCT04617366
- Testing
- Individualized rTMS strategy, Traditional rTMS strategy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diabetes, Cardiovascular Disease
Associations Between Diabetes Care and Haptoglobin Genotype On outComes
The ADHOC Cohort comprised 3044 DM individuals, treated in 47 CHS primary care clinics, that underwent haptoglobin genotyping between 2 march, 2005 and 26 September 2006.
- Conditions
- Diabetes, Cardiovascular Disease, Myocardial Infarction, Stroke
- Trial name
- ADHOC (NCT00872456)
- Volunteers
- 3,054 people
- Sponsor
- Clalit Health Services
Visual Fields Hemianopsia, Stroke, Ischemic
Repetitive Transcranial Magnetic Stimulation for Post-Stroke Visual Field Defects
Visual field defects (VFD) usually do not show improvement beyond 12 weeks from onset. Plasticity occurs in areas of residual vision (ARV) at the visual field which are the functional counterpart of partially damaged brain…
- Conditions
- Visual Fields Hemianopsia, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- NCT04021160
- Testing
- High frequency repetitive transcranial magnetic stimulation (rTMS)
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Ain Shams University
Non-Valvular Atrial Fibrillation
A Study to Collect Information on the Characteristics of Elderly Belgian Patients With NVAF That Are Treated With a NOAC for This Indication With a Special Focus on Their Fear of Bleeding While Using a NOAC vs the Clinical Benefit of a NOAC of Thrombosis/Stroke Prevention.
Atrial fibrillation is a heart condition that causes an abnormal and fast heart rate. For people with non-valvular atrial fibrillation (NVAF), this is caused by problems such as high blood pressure and diabetes.
- Trial name
- BELANCE (NCT04722679)
- Testing
- Non-VKA Oral Anticoagulants (NOAC)
- Where
- Belgium
- Volunteers
- 103 people
- Sponsor
- Bayer
Stroke
Action Observation and Motor Imagery Therapy in Stroke
In recent years, motor imagery (MI) and action observation (AO) therapy strategies have been used in rehabilitation programs to increase motor learning in stroke.
- Trial name
- NCT06166862
- Testing
- Action observation and motor imagery therapy for rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Karamanoğlu Mehmetbey University
Stroke
Investigation of the Use of Acupuncture for the Treatment of Spasticity in Chronic Stroke Participants
The purpose of this study is to investigate if acupuncture is more effective than sham treatment in reducing lower extremity spasticity, and improving gait speed in the chronic phase of stroke recovery.
- Trial name
- HHSCSTROKEAC (NCT02085642)
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Acute Ischemic Stroke
REVascularization In Large VEssel Occlusion for Acute Ischemic Stroke
The objective of this study is to evaluate the safety and effectiveness of the SOFIA Flow 88 Aspiration Catheter for treatment of acute ischemic stroke.
- Trial name
- REVIVE (NCT07216170)
- Testing
- SOFIA Flow 88 Aspiration Catheter
- Volunteers
- 200 people
- Sponsor
- Microvention-Terumo, Inc.
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