Clinical trials: Stroke, Mechanism
Stroke
Study of Neurophysiological Markers of Motor Recovery in Post-stroke Patients.
The aim of the study was to explore potential pathways for recovery and adaptation of neural pathways after stroke by examining electrical activity of the brain cortex and cortico-spinal excitability using transcranial magnetic…
- Trial name
- NCT06386627
- Testing
- Stimulus response task, Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Stroke Patients With Cognitive Decline
Effects and Mechanism of Two Hybrid Exercise-cognitive Trainings in Mild Ischemic Stroke With Cognitive Decline
The purposes are to: (1) examine and compare the effects of two hybrid interventions on brain plasticity, physiological biomarkers and behavioral outcomes, including cognitive and physical functions, from pre- to post-training…
- Trial name
- NCT03230253
- Testing
- Sequential training, Dual training, Control training
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Chang Gung Memorial Hospital
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Central Post-stroke Pain, CPSP
Neuromodulation for Central Post-stroke Pain: Mechanism, Safety and Outcome
Central post-stroke pain (CPSP) is an often pharmacorefractory type of neuropathic pain that develops in 8% of stroke patients. CPSP has been treated with three distinct types of neuromodulation (deep brain stimulation of the…
- Trial name
- NCT05708729
- Testing
- MCS surgery for CPSP, Vc-DBS surgery for CPSP
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke
Investigation of Acceptable Dose of Mobilisation and Tactile Stimulation to Enhance Upper Limb Recovery After Stroke
The purpose of this study is to find which of three doses of mobilisation and tactile stimulation therapy, when given in addition to conventional UK physical therapy, has the most beneficial effect on enhancing motor recovery of…
- Trial name
- NCT00360997
- Testing
- Conventional UK physical therapy, Con UK PT + Mobilisation & tactile stimulation (MTS)
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- St George's, University of London
Aphasia, Anomic
Mechanisms Underlying Spoken Language Production
Most of us take being able to communicate for granted. Anomia (word finding problems) after stroke can cause profound frustration and anxiety for patients and families. Some people recover; many don't.
- Trial name
- NCT04138433
- Testing
- Real tDCS
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University College London Hospitals
Acupuncture, Dysphagia
Efficacy and Mechanism of 'Yanjiu Needle' for Pharyngeal Dysphagia Based on sEMG Features
Dysphagia is one of the most common and serious complications following stroke. It can easily lead to aspiration and aspiration pneumonia, reduce patients' quality of life, increase healthcare costs, and result in high mortality…
- Conditions
- Acupuncture, Dysphagia, Surface EMG
- Trial name
- NCT07656025
- Testing
- Yanjiu Acupuncture, a three-point acupuncture technique, control group
- Volunteers
- 100 people
- Sponsor
- The Third People's Hospital of Huizhou
Cardio-cerebral Vascular Events, Arteriovenous Fistula Dysfunction
Impact and Mechanism of Depression on Cardio-cerebral Vascular Events and Arteriovenous Fistula Dysfunction in MHD Patients
Depression is a common psychiatric disorder in patients on maintenance hemodialysis (MHD). It may contribute to poor prognosis in a number of ways, including its effect on platelet function.
- Trial name
- NCT06070805
- Testing
- depression
- Where
- China
- Volunteers
- 286 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Stroke, Dysphagia
Volitional Swallowing in Stroke Patients With Chronic Dysphagia
This study will compare several techniques designed to improve the ability to swallow in stroke patients with chronic dysphagia (difficulty swallowing).
- Trial name
- NCT00306501
- Testing
- Swallowing Training
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Fast Stepping in Stroke Patients for Fall Prediction and Prevention:Control Mechanisms and Clinical Implications
The purpose of this study was to compare the balance strategy, as well as center of pressure (COP) trajectory and parameters between healthy adults and patients with hemiplegia in response to slow- and fast-speed waist- pulling…
- Trial name
- NCT00167037
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spasticity as Sequela of Stroke
Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System
Spasticity can make regular daily activities difficult or impossible. Cryoneurolysis is a new technique to treat spasticity that is currently being tested.
- Trial name
- NCT06958289
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sue Peters
Stroke, Acute
The Intravascular Cooling in the Treatment of Stroke 2/3 Trial
The purpose of this trial is to determine whether the combination of thrombolysis and hypothermia is superior to thrombolysis alone for the treatment of acute ischemic stroke.
- Trial name
- ICTuS2/3 (NCT01123161)
- Testing
- hypothermia and anti-shivering treatment, Group1: IV t-PA and normothermia
- Where
- 31 sites in United States, Austria and 1 more
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Ischemic Strokes, Traditional Chinese Medicine (TCM)
Spatiotemporal Evolution of Traditional Chinese Medicine Mechanisms in Acute Ischemic Stroke Treated With Dengzhan Xixin and Dengzhan Shengmai
To integrate large-scale RCT data on clinical symptoms, TCM syndromes, prognosis, and multi-omics profiles, construct a spatiotemporal dynamic network for disease-syndrome evolution of acute ischemic stroke (AIS) in the acute and…
- Conditions
- Ischemic Strokes, Traditional Chinese Medicine (TCM), Prognosis
- Trial name
- STEM-DZ (NCT07591883)
- Testing
- Dengzhan Shengmai - Erigeron breviscapus sequential intervention, corresponding control group sequential intervention
- Volunteers
- 358 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Stroke
Study of the Pathogenesis and Molecular Mechanism of "YURE" in Internal Intractable Diseases
The purpose of this study is to determine whether the Chinese herbs formula is effective in the treatment of hemorrhagic stroke and to find out Chinese pathogeny and pathogenesis in the disease.
- Trial name
- NCT00569088
- Testing
- Chinese herbs formula, Mannitol
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Stroke
High-definition Transcranial Electrical Stimulation for Upper Extremity Rehabilitation
Upper limb hemiparesis is the most common sequelae in patients, severely impacting their independence and quality of life. Transcranial electrical stimulation (tCES) is a non-invasive and safe treatment, which uses a low direct…
- Trial name
- NCT06409143
- Testing
- HD-tES, UE rehabilitation, HD-tES (Bilateral)
- Where
- 3 sites in Taiwan
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stroke, Mild Cognitive Impairment
tDCS for Post-Stroke Cognitive Impairment
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in participants with post-stroke cognitive impairment (PSCI).
- Trial name
- NCT06516588
- Testing
- Transcranial Dirrect Current Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Ischemic Stroke
Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2)
Patients presenting to the emergency department with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be assessed for major vessel occlusion to determine their…
- Trial name
- NCT03340493
- Testing
- Tenecteplase
- Where
- 28 sites in Australia, New Zealand
- Volunteers
- 300 people
- Sponsor
- Neuroscience Trials Australia
Stroke
Mechanisms of Neuromuscular Fatigue Post Stroke
While baseline weakness is clearly an important factor that contributes to disability post stroke, neuromuscular fatigue (the acute reduction in force production) of the paretic musculature likely compounds strength deficits and…
- Trial name
- NCT01688570
- Testing
- duloxetine, Cyproheptadine
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Coronary Artery Disease, Cerebral Stroke
Mechanistic Study of Bleeding Risk in Coronary Patients With Cerebrovascular Disease
Background: About 5% of patients with acute coronary syndrome (ACS) have had previously ischemic stroke (IS) or transitory ischemic attack (TIA).
- Conditions
- Coronary Artery Disease, Cerebral Stroke, TIA (Transient Ischemic Attack)
- Trial name
- NCT02316119
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke
Cognitive Training After Stroke : Effects and Mechanisms
Stroke is a major cause of severe cognitive and physical disability. Despite the high and increasing incidence, and large health, economic, social and personal consequences, studies designed to remedy cognitive impairments and…
- Trial name
- NCT04932304
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Oslo University Hospital