Clinical trials: Stroke/TIA
Stroke, Transient Ischemic Attack
GORE® Septal Occluder Device for Patent Foramen Ovale (PFO) Closure in Stroke Patients
The primary objective is to determine if patent foramen ovale (PFO) closure with the GORE® HELEX® Septal Occluder or GORE® CARDIOFORM Septal Occluder plus antiplatelet medical management is safe and effective and reduces the risk…
- Trial name
- REDUCE (NCT00738894)
- Testing
- Septal Occluder Device, Antiplatelet Medical Therapy
- Where
- 2 sites in United States, Denmark
- Volunteers
- 664 people
- Sponsor
- W.L.Gore & Associates
Transient Ischemic Attack, Carotid Stenosis
EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis
The purpose of this study is to evaluate whether carotid angioplasty with stent (CAS) is as safe and effective as carotid surgery in regards to: 1. the risk of stroke and death within 30 days of the procedure; 2.
- Conditions
- Transient Ischemic Attack, Carotid Stenosis, Atherosclerosis
- Trial name
- NCT00190398
- Testing
- Carotid angioplasty and stenting with cerebral protection
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke, TIA
Stroke Card Long-term Follow-Up
We undertook the STROKE-CARD trial (NCT02156778) between 2014 and 2018 with follow-up until 2019 to evaluate the efficacy of the Post-Stroke disease-management program STROKE-CARD care.
- Trial name
- NCT04205006
- Where
- 2 sites in Austria
- Volunteers
- 1,000 people
- Sponsor
- Medical University Innsbruck
Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction
Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated…
- Conditions
- Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses
- Trial name
- IMPROVE (NCT07556887)
- Testing
- IMPROVE Risk Model
- Where
- 10 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- Maastricht University Medical Center
Stroke, Ischemic Attack, Transient
Carotid Plaque Imaging in Acute Stroke
The purpose of this study is to determine the frequency, characteristics, and consequences of vulnerable carotid artery plaques ipsilateral to an acute ischemic stroke or TIA in the territory of the internal carotid artery.
- Trial name
- CAPIAS (NCT01284933)
- Where
- 4 sites in Germany
- Volunteers
- 234 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Carotid Artery Stenosis, Head and Neck Cancer
Carotid Artery Stenosis and Ischemic Cerebrovascular Events After Radiotherapy in Patients With Head and Neck Cancer
The study had a cross-sectional design and included patients with HNC involving the oral cavity, pharynx, larynx, nasal cavity, or salivary glands who recieve RT.
- Conditions
- Carotid Artery Stenosis, Head and Neck Cancer, Radiation Therapy, Transient Ischemic Attack
- Trial name
- RT-CASinHNC (NCT06556979)
- Testing
- Radiotherapy
- Where
- Thailand
- Volunteers
- 907 people
- Sponsor
- Chulabhorn Royal Academy
Fatigue, Stroke, Acute
Microstructure Imaging in Stroke Patients
The purpose of this study is to establish a methodological framework based on existing advanced neuroimaging technologies as a new clinical neuroimaging tool for assessment of possible affected brain connections in stroke and TIA…
- Conditions
- Fatigue, Stroke, Acute, Transient Ischemic Attack
- Trial name
- NCT04118790
- Testing
- Clinical Assessment, MRI scan
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Stroke (CVA) or TIA
Additional Effects of Vagus Nerve Stimulation on Motor Functions of Upper-limb in Stroke
The study aims to determine the additional effects of vagus nerve stimulation with task-oriented training on motor functions of upper-limb in stroke
- Trial name
- NCT05771805
- Testing
- Vagus nerve stimulation with task oriented training, Task oriented training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Ischemic Stroke, TIA
Determining the MCID for the TOPICS-SF and PROMIS-10 in Older Patients That Suffered an Ischemic Stroke or TIA
Patient-related outcome measures (PROMs) play a crucial role in assessing patient outcomes in healthcare. Two of these PROMs are the The Older Persons and Informal Caregivers Survey Short Form (TOPICS-SF) and Patient-Reported…
- Trial name
- CONSIDER (NCT06495073)
- Testing
- PROMIS-10 and TOPICS-SF
- Where
- 2 sites in Netherlands
- Volunteers
- 125 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Transient Ischemic Attack, Non-disabling Stroke
Prevention of Ischemic Conditions in Non-disabling Stroke/Transient Ischemic Attack With Remote Ischemic Conditioning
This is a single-arm, open-labeled and phase II futility study. Application of Remote ischemic conditioning (RIC) as an adjunctive therapy to medication were involved in the study.
- Trial name
- PICNIC-ONE (NCT03004820)
- Testing
- Remote Ischemic Conditioning
- Where
- 4 sites in China
- Volunteers
- 167 people
- Sponsor
- Capital Medical University
Ischemic Stroke
Combining Aspirin With Ticagrelor or Clopidogrel in Minor Stroke or TIA
Along with the current clinical trial, the efficacy and safety of a 180 mg loading dose of ticagrelor administered within 24 hours of the first-ever minor stroke or TIA compared to 300 mg clopidogrel were assessed through NIHSS…
- Trial name
- NCT06591312
- Testing
- Ticagrelor 90 MG, Clopidogrel
- Where
- Egypt
- Volunteers
- 900 people
- Sponsor
- Kafrelsheikh University
Stroke, Ischemic Attack, Transient
Performing a Low-dose, Whole-body Angiography as the First Element of an Imaging Assessment Following Stroke / TIA
The main objective of this study is to compare two post-stroke/TIA (transient ischemic attack) imaging strategies in terms of the number of clinically important (i.e.
- Trial name
- VASCU (NCT02662751)
- Testing
- Routine Imaging Assessment, LDWBA first (CT scan)
- Where
- 2 sites in France
- Volunteers
- 260 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ischemic Stroke, TIA
Personalized Antiplatelet Secondary Stroke PRevenTion
This is a descriptive study designed to evaluate the safety and feasibility of a precision medicine approach to antiplatelet selection for secondary stroke prevention.
- Trial name
- PASSPoRT (NCT03979781)
- Testing
- tailored antiplatelet selection, standard of care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- State University of New York - Upstate Medical University
Sleep Apnea Syndromes, Sleep Initiation and Maintenance Disorders
Sleep Deficiency and Stroke Outcome
Deficient sleep duration and sleep disturbances - such as insomnia, sleep disordered breathing (SDB) and restless legs syndrome (RLS)- are associated with hypertension and cardio-cerebrovascular morbidity and mortality.
- Conditions
- Sleep Apnea Syndromes, Sleep Initiation and Maintenance Disorders, Insomnia, Restless Legs Syndrome
- Trial name
- NCT02559739
- Where
- 2 sites in Switzerland
- Volunteers
- 447 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebrovascular Accident
Transient Ischemic Attack (TIA) Triage and Evaluation of Stroke Risk
Transient ischemic attack (TIA) is a transient neurological deficit (speech disturbance, weakness…), caused by temporary occlusion of a brain vessel by a blood clot that leaves no lasting effect.
- Trial name
- NCT01423201
- Where
- 3 sites in United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Stanford University
Stroke
Global Impact of the COVID 19 Pandemic on Stroke Care, Cerebral Venous Thrombosis, and Subarachnoid Hemorrhage
A 1-year analysis of global selected stroke metric data will be conducted comparing the results during the Covid-19 pandemic to the pre-pandemic period.
- Trial name
- NCT04934020
- Testing
- Pre-pandemic stroke related metrics, Stroke related metrics during the pandemic
- Where
- 2 sites in United States
- Volunteers
- 345,089 people
- Sponsor
- Boston Medical Center
Cerebrovascular Accident, Transient Ischemic Attack
Safety Study of Atomoxetine and Cerebrovascular Outcomes
Using a proprietary insurance health claims database, Eli Lilly and Company has contracted with an external party to conduct a retrospective cohort study of health claims for the time period from 1 January 2003 through 31…
- Conditions
- Cerebrovascular Accident, Transient Ischemic Attack, ADHD
- Trial name
- NCT00634439
- Testing
- atomoxetine, Stimulants, No intervention (general population)
- Where
- United States
- Volunteers
- 72,000 people
- Sponsor
- Eli Lilly and Company
Stroke, Transient Ischemic Attack (TIA)
PROspective Study to OPTimize thE HEALTH of Patients With TIAs (Transient Ischemic Attacks) and Stroke Admitted to the Hamad General Hospital
This will be a prospective randomized 2 year study of patients admitted to the Hamad General Hospital (HGH) and the Stroke Prevention Clinic with a diagnosis of ischemic stroke (IS) and Transit ischemic attacks (TIAs).
- Trial name
- PROMOTE-HEALTH (NCT02868723)
- Testing
- Aggressive Management
- Where
- Qatar
- Volunteers
- 400 people
- Sponsor
- Hamad Medical Corporation
Stroke, Cerebrovascular Diseases
An EHR-based Platform To Facilitate Outcomes and Research Methods in Cerebrovascular Diseases
In this protocol, the investigators present methods and preliminary results from the PLATFORM-CVD Study, an EHR-based multicenter cohort.
- Conditions
- Stroke, Cerebrovascular Diseases, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- PLATFORM-CVD (NCT04775836)
- Where
- China
- Volunteers
- 300,000 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Stroke (CVA) or TIA, Memory Impairment
Investigating the Efficacy of ApplTree on Prospective Memory in Stroke
After a stroke, people can experience memory problems, including difficulty remembering to do things in the future - termed "prospective memory".
- Trial name
- NCT05658315
- Testing
- ApplTree smartphone application
- Volunteers
- 6 people
- Sponsor
- NHS Greater Glasgow and Clyde