Clinical trials: Stroke, suspended
Non-valvular Atrial Fibrillation, Stroke
A Pivotal Investigational Device Exemption Study on Laminar Left Atrial Appendage Elimination
The purpose of this study is to compare the safety and effectiveness of Laminar Left Atrial Appendage Closure (LAAC) device as compared to the commercially available LAAC devices in participants with non-valvular atrial…
- Conditions
- Non-valvular Atrial Fibrillation, Stroke, Systemic Embolism
- Trial name
- NCT06168942
- Testing
- Experimental: Laminar Left Atrial Appendage Closure System, Active Comparator: WATCHMAN / Amulet
- Where
- 36 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Jaguar LAA, Inc.
Atrial Fibrillation, Stroke
The CONFORM Pivotal Trial
The CLAAS® device will be evaluated for safety and efficacy by establishing its performance is non-inferior to the commercially available WATCHMAN® and Amulet™ left atrial appendage closure devices in patients with non-valvular…
- Trial name
- NCT05147792
- Testing
- CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
- Where
- 94 sites in United States, Czechia and 4 more
- Volunteers
- 1,600 people
- Sponsor
- Conformal Medical, Inc
Hemianopia, Homonymous
Comparative Efficacy of Saccadic and Biofeedback Training in Homonymous Hemianopia
This pilot study aims to understand how eye movements change in people with vision loss from stroke after completing one of two types of training.
- Trial name
- NCT06638619
- Testing
- Biofeedback Fixation Training, Saccadic Reading Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Cerebrovascular Disorders
Identification of microRNAs Involved in Cerebral Collateral Regulation
Patients >18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will…
- Trial name
- microRNA (NCT03905434)
- Testing
- miRNA sampling
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Stroke, Spinal Cord Injuries
Human-like Robotic Controllers for Enhanced Motor Learning
The purpose of this study is to develop a new paradigm to understand how humans physically interact with each other at a single and at multiple joints, with multiple contact points, so as to synthesize robot controllers that can…
- Trial name
- HRCEML (NCT04578665)
- Testing
- Behavioral Interaction Conditions, Haptic Impedance Level, Skill Level of Partner
- Where
- United States
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Real-time Neuromuscular Control of Exoskeletons
The purpose of this study is to develop a real-time controller for exoskeletons using neural information embedded in human musculature.
- Trial name
- NCT04661891
- Testing
- Isometric contractions, Isokinetic contractions, Dynamic contractions
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Tracking Neural Synergies After Stroke.
The purpose of this study is to identify neural muscle synergies of patients post-stroke and track them during an inpatient acute rehabilitation.
- Trial name
- NCT04805866
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Muscle Coordination-Based Feedback for Stroke Rehabilitation
The purpose of this study is to compare two interventions currently used to improve gait and lower limb function in individuals with chronic stroke (i.e., high-intensity gait training and high-intensity gait training with…
- Trial name
- NCT06099444
- Testing
- Conventional High Intensity Gait Training, Standard FES to the Tibialis Anterior (TA), Synergy-Based Multichannel FES (MFES)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Evaluation of Sensorimotor Ankle Impairments in Chronic Stroke
The purpose of this study is to capture sensorimotor ankle function in a chronic stroke population through validation of novel, experimental metrics and their comparison with established, clinical measures of function.
- Trial name
- NCT06410989
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
GRAViceptive NEGlect Treatment in Acute Stroke Using Targeted Cranial ELECTrotherapy
We aim to determine if targeted high-definition transcranial direct current stimulation (HD-tDCS) can safely correct errors in visual verticality perception in patients after stroke affecting either hemisphere.
- Trial name
- GravNegElect (NCT06747676)
- Testing
- Active: High-Definition transcranial Direct Current Stimulation (HD-tDCS)
- Where
- 2 sites in Brazil
- Volunteers
- 28 people
- Sponsor
- University of Sao Paulo
Stroke
The Effect of SRS on Hemiplegia in Stroke Survivors
Strokes are one of the leading causes of long term disability and death in the United States. A stroke occurs when the blood supply to the brain is blocked, damaging parts of the brain.
- Trial name
- NCT06357247
- Testing
- Sensory Threshold, Nine Hole Peg Test, Semmes Weinstein Monofilament Assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Hemorrhagic Stroke
Delipid Extracorporeal Lipoprotein Filter From Plasma (DELP) for Acute Hemorrhagic Stroke
Delipid Extracorporeal Lipoprotein filter from Plasma (DELP) has been found to improve neurological function and life ability of AIS patients and approved for the treatment of AIS by China Food and Drug Administration (CFDA).
- Trial name
- NCT05128513
- Testing
- DELP
- Where
- China
- Volunteers
- 356 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Acute, Stroke, Ischemic
Post-Stroke Enhancement of Delirium Outcomes With Reduction in Neuro-checks
There have been limited studies on delirium in patients hospitalized with acute stroke. There have been no studies on the potential impact of overnight neuro-checks and resulting sleep disruption on delirium or other outcomes.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Delirium, Neuro: Cerebrovascular Accident
- Trial name
- SNDOWN (NCT06038136)
- Testing
- Decreased Neuro Checks overnight
- Where
- United States
- Volunteers
- 538 people
- Sponsor
- Medical University of South Carolina
Stroke, Dementia
Nut Supplementation to Mitigate Post-stroke Cognitive Decline
Stroke is a strong risk factor for dementia, with up to 80% of individuals having lower cognitive function 5 years after a stroke event.
- Trial name
- NUT-me (NCT05902767)
- Testing
- Nuts, Control
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Monash University
Stroke, Acute
Endovascular Acute Stroke Intervention Trial - the EASI Trial
Stroke constitutes the primary cause of acquired disability in adults and the second cause of dementia following Alzheimer disease.
- Trial name
- EASI (NCT02157532)
- Testing
- mechanical thrombectomy, Best standard treatment
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Stroke, Spasticity, Muscle
Robotic Interventions for Spasticity Treatment
The researchers have developed games controlled by electromyographic (EMG) and inertial measurement unit (IMU) activity recorded by a sensor.
- Trial name
- NCT05006248
- Testing
- Conventional robotic continuous passive movement training, Visual Feedback, Haptic and Visual Feedback
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
The Effect of Covered Eye Walking on Electroencephalogram in Stroke Patients Compared With Open Eye Walking
Post-stroke walking abnormalities present significant rehabilitation challenges. Visual deprivation training has been shown to be more effective than open-eye training.
- Trial name
- NCT06234618
- Testing
- visual deprivation
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Nanjing Medical University
Acute Ischemic Stroke
Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke
The primary objective of the study is to confirm the efficacy of compound Edaravone Injection via intravenous infusion every 12 hours in the patients with Acute Ischemic Stroke(AIS) in a double-blind, active-controlled manner.
- Trial name
- NCT04984577
- Testing
- Compound Edaravone Injection-Low dose, Compound Edaravone Injection-High dose, Edaravone Injection
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Nanjing Yoko Biomedical Co., Ltd.
Stroke, Hemiplegia
Robot-Assisted Stroke Rehabilitation Based on Patient-Therapist Interactions
Our study goal is to assess natural patient-therapist interactions in order to map such human-human activities to robot-human interactions.
- Conditions
- Stroke, Hemiplegia, Healthy
- Trial name
- Baxter (NCT02806843)
- Testing
- Rehab InterCap system and 3D Kinect
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Stroke
Impact of Non-invasive Brain Stimulation on Motor Recuperation
tDCS (transcranial direct current stimulation) will be used in chronic stroke patients to improve a variety of functions with superior or inferior limb.
- Trial name
- NCT01544699
- Testing
- tDCS (ELDITH)
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne