Clinical trials: Strokes
Assessment of Intravascular Volume Status in Mechanically Ventilated Critically Ill Patients
Evaluation of Jugular Venous Distensibility Index in Intravascular Fluid Management and Comparison of the Effectiveness of Noninvasive and Minimally Invasive Methods
Assessment of intravascular volume status is an important component of hemodynamic management in critically ill patients. Several noninvasive and minimally invasive parameters, including the pleth variability index (PVI), pulse…
- Trial name
- NCT07807709
- Testing
- Pleth variability index, Pulse pressure variation, Stroke volume variation
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Stroke, Spasticity
Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients
Spasticity, muscle weakness, abnormal gait pattern are co-morbidities commonly seen in stroke patients. They cause disabled condition of patients in activities of daily life and functional performance, and also accidental falls…
- Trial name
- NCT01817816
- Testing
- Botox_A, Botox_B
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Changhua Christian Hospital
Stroke, Ischemic
Trevo Aspiration Proximal Flow Control Registry
This purpose of this retrospective, single-arm, non-randomized, multi-center study is to collect real-world data on the effectiveness of using the TRAP technique in acute ischemic stroke patients undergoing mechanical…
- Trial name
- TRAP (NCT03199404)
- Testing
- TRAP
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Massachusetts, Worcester
Stroke
Transcranial Direct Current Stimulation Combined Sensory Modulation Intervention in Chronic Stroke Patients
Background and purpose: About 30% of people with stroke suffered from severe long-term upper extremity （UE） motor impairment. Severe UE impairment, especially dysfunction of hand, can greatly impact stroke patients' daily living…
- Trial name
- NCT01847157
- Testing
- tDCS, Epidermis anesthesia, Repeated passive movement
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- National Taiwan University Hospital
Acute Ischemic Stroke, Atrial Fibrillation
Early Versus Late Initiation of Anticoagulation in Mild-to-moderate AIS Patients With NVAF
The goal of this clinical trial is to compare the effectiveness between early and late initiation of anticoagulation therapy in acute ischemic stroke (AIS) patients with non-valvular atrial fibrillation (NVAF).
- Trial name
- ASAP (NCT06057467)
- Testing
- Anticoagulation Agents
- Where
- 2 sites in China
- Volunteers
- 2,351 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Research With Clinical Staff in Stroke Rehabilitation
Usability Study of OnTrack Tools
Aims: Assess the usability of OnTrack Tools, a clinician facing interface to manage stroke survivors using the OnTrack rehabilitation system.
- Trial name
- NCT05330234
- Testing
- OnTrack Tools
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Traumatic Brain Injury, CVA (Cerebrovascular Accident)
The Brain Injury Neurorehabilitation Project
The primary objective of The Brain Injury Neurorehabilitation Project is a systematic effort to generate cutting edge research in brain injury and cognitive rehabilitation that will advance neurorehabilitation research.
- Trial name
- NCT06556316
- Testing
- Cognitive Intervention with the Categorization Program, Social Cognitive Communication Program, Non-Invasive Brain Stimulation with tDCS
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Stroke, Hemiparesis
Long Term Split Belt Treadmill Training for Stroke Recovery
The purpose of this study is to determine whether split belt or conventional treadmill training can be used to treat walking pattern deficits from stroke and to determine whether this improves gait asymmetry and metabolic…
- Trial name
- NCT01646216
- Testing
- Split belt treadmill
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Poststroke/CVA Paresis
Efficacy of Hand Exoskeleton Controlled by BCI in Post Stroke Patients
The purpose of this study is to assess the efficacy of non-invasive BCI-exoskeleton technology based on EEG patterns recognition matching to motor imagery in post-stroke patients with hand paresis.
- Trial name
- iMove (NCT02325947)
- Testing
- hand exoskeleton, brain-computer interface (BCI),
- Where
- Russia
- Volunteers
- 75 people
- Sponsor
- Russian Academy of Medical Sciences
Paralytic Stroke, Cough
Diaphragmatic Function in Stroke Patients.
This study attempts to elucidate whether stroke patients with dysphagia have reduced diaphragm movement during voluntary coughing, and also during deep inspiration and expiration than stroke patients without dysphagia.
- Trial name
- NCT01637649
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Stroke
Dynamic-orthosis Programs for Stroke Hand Function
This study aims to investigate the training benefits of modular 3D printed dynamic orthoses on upper limb function in stroke survivors.
- Trial name
- NCT06271187
- Testing
- Dynamic-orthosis, Traditional stroke occupational therapy training
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Cheng-Kung University Hospital
Aphasia, Stroke
Can Listening to Music Improve Attention and Language After Post-Stroke Aphasia?
The goal of this clinical trial is to learn if a music-based intervention can acutely improve three types of attention (alerting, orientating, executive control) in people with aphasia following a stroke.
- Conditions
- Aphasia, Stroke, Stroke and Aphasia, Stroke Hemorrhagic
- Trial name
- NCT07198048
- Testing
- Music-Based Therapy for Post Stroke Aphasia, Audiobook Intervention for Post Stroke Aphasia
- Volunteers
- 45 people
- Sponsor
- Purdue University
Acute Ischemic Stroke
Tenecteplase in Acute Ischemic Stroke Under Different Transfer Models
This prospective, multicenter, observational cohort study aims to evaluate the safety and effectiveness of intravenous tenecteplase (rhTNK-tPA) in patients with acute ischemic stroke managed under different transfer models.
- Trial name
- NCT07897955
- Testing
- tenecteplase
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Fujian Medical University Union Hospital
Stroke, Traumatic Brain Injury
Validation of an Obstacle Course Used in Patients With Muscle Tightness
This study is being conducted to compare healthy patients versus patients with muscle tightness in their leg(s) after an acquired brain injury using walking trials time, a balance test, and foot pressure data.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis, Spasticity
- Trial name
- NCT00776048
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Ischemic Stroke, Transient Ischemic Attack
Platelet Aggregation Function-Guided De-Escalation Antiplatelet Therapy in Patients With Acute Ischemic Stroke
This multicenter, prospective, open-label, randomized controlled trial will evaluate whether platelet aggregation function-guided de-escalation of antiplatelet therapy is non-inferior in efficacy and superior in safety compared…
- Trial name
- PATH STROKE D (NCT07644234)
- Testing
- Clopidogrel, Aspirin
- Where
- China
- Volunteers
- 3,836 people
- Sponsor
- Sichuan Provincial People's Hospital
Minor Ischemic Stroke
Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ
The purpose of this study is to evaluate the efficacy and safety of intravenous tenecteplase (0.25 mg/kg) compared with standard therapy in patients with acute ischemic stroke presenting with mild symptoms-defined as a National…
- Trial name
- TRACE Ⅳ (NCT06414499)
- Testing
- rhTNK-tPA, Control group (Aspirin combined with clopidogrel)
- Where
- China
- Volunteers
- 1,386 people
- Sponsor
- Beijing Tiantan Hospital
Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
The purpose of this study is to determine whether a single treatment with administration of 400 Units NT 201 (botulinum toxin) is superior to placebo (no medicine) for the treatment of lower limb spasticity caused by stroke or…
- Trial name
- PATTERN (NCT03992404)
- Testing
- NT 201
- Where
- 71 sites in United States, Belgium and 13 more
- Volunteers
- 603 people
- Sponsor
- Merz Pharmaceuticals GmbH
Ischemic Stroke
Evaluation of the Safety and Performance of Magneto Microcatheter
A prospective, open label single arm feasibility study to evaluate the safety and performance of the Magneto Microcatheter in patients diagnosed with acute ischemic stroke and planned for thrombectomy procedure.
- Trial name
- NCT04466033
- Testing
- Magneto Microcatheter
- Where
- 3 sites in Hungary, Israel
- Volunteers
- 4 people
- Sponsor
- Magneto Thrombectomy Solutions
Stroke
Is the Rehabilitation Robotic a Safe and Effective Choice for Stroke Patients?
The effectiveness of robotic over conventional therapy is arguable and the best therapy strategy is still not clear. Basing on the existing evidence on motor learning and practice-induced neuroplasticity, the investigators plan…
- Trial name
- NCT03290833
- Testing
- Robotic, Conventional therapy
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Ten-Chen General Hospital
Acute Ischemic Stroke
Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke
The manipulation of blood pressure in acute cerebral ischemia has been a matter of debate until now. The investigators are clearly in need of more detailed data on how antihypertensive treatment affects outcome in acute phase of…
- Trial name
- VENTURE (NCT00874601)
- Testing
- Diovan® (valsartan)
- Where
- South Korea
- Volunteers
- 578 people
- Sponsor
- Hallym University Medical Center
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