Clinical trials: Strokes
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Acute Ischemic Stroke
Efficacy and Safety Study of DP-b99 in Treating Acute Ischemic Stroke
The purpose of this trial is to determine if intravenous administration of the metal ion trapping agent DP-b99 up to 9 hours following acute ischemic stroke onset, and then for 3 additional days (4 consecutive days in total) is…
- Trial name
- MACSI (NCT00893867)
- Testing
- DP-b99
- Where
- 154 sites in United States, Austria and 16 more
- Volunteers
- 446 people
- Sponsor
- D-Pharm Ltd.
Stroke, Acute, Cerebral Infarction
Virtual Reality Glove for Hand and Arm Rehabilitation After Stroke
The Virtual Reality Glove for Hand and Arm Rehabilitation (vREHAB) trial is a randomized, controlled, phase 3 trial aiming to evaluate the safety, usability, and efficacy of a virtual reality biofeedback system (Neofect RAPAEL…
- Trial name
- vREHAB (NCT03741400)
- Testing
- Neofect RAPAEL Smart Glove
- Where
- 4 sites in United States, Belgium
- Volunteers
- 60 people
- Sponsor
- Stanford University
Stroke
EMG Controlled Device in Acute Rehabilitation After Acute Stroke
Stroke is a medically relevant problem for the aging population. Individuals with stroke experience a high amount of arm functional deficits despite receiving rehabilitation.
- Trial name
- NCT04599036
- Testing
- MARK
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Non-valvular Atrial Fibrillation
Evaluation of Effectiveness and Safety of Xa Inhibitor for the Prevention of Stroke And Systemic Embolism in a Nationwide Cohort of Japanese Patients Diagnosed as Non-valvular Atrial Fibrillation
The efficacy and safety of a novel oral Xa inhibitor for stroke and systemic embolism, namely rivaroxaban, in non-valvular atrial fibrillation patients are evaluated in Japanese clinical practice.
- Trial name
- EXPAND (NCT02147444)
- Where
- Japan
- Volunteers
- 7,000 people
- Sponsor
- Tohoku University
Acute Ischemic Stroke
Intravenous Thrombolysis and NOAC
New oral anticoagulants (NOACs), including rivaroxaban, apixaban, dabigatran, and edoxaban, have become the first-line therapy for preventing ischemic stroke associated with non-valvular atrial fibrillation (NVAF).
- Trial name
- NCT06749834
- Testing
- Intravenous thrombolysis
- Where
- 2 sites in China
- Volunteers
- 280 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Fabry Disease
Alternative Dosing and Regimen of Replagal to Treat Fabry Disease
The main goal of this study is to assess the pharmacodynamic effects of different or more frequent doses of Replagal compared to the standard dosing regimen.
- Trial name
- NCT00075244
- Testing
- Replagal
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Virtual Reality
The Effects of Balance Trainer
The trunk is reference and key region of body in terms of both mobility and stability. Sufficient stability in the trunk is essential for the execution of intentional extremity movements.
- Trial name
- NCT06166004
- Testing
- Balance Training, Person-Specific Rehabilitation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara Yildirim Beyazıt University
Cerebral Microangiopathy, CADASIL
Impact of tDCS on Cerebral Autoregulation
The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.
- Conditions
- Cerebral Microangiopathy, CADASIL, Migraine With Aura, ICA Stenosis
- Trial name
- NCT01865604
- Testing
- Anodal tDCS, Cathodal tDCS
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Acute Ischemic Stroke (AIS), Acute Ischemic Stroke From Large Vessel Occlusion
Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke
Since 2015, many randomized trials have shown that endovascular thrombectomy improve functional outcomes in acute ischemic stroke patients with large vessel occlusion.
- Trial name
- XL-STROKE (NCT06210633)
- Testing
- medical management, endovascular thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhongming Qiu
Patients (>=60 Years Old) Suffering From Mild-moderate Stroke (Ischemic or Hemorrhagic, Stroke Severity Assessed by NIHSS <16 Points)
IMAGINE Study Protocol
Background: Rehabilitation pathways are crucial to reduce stroke-related disability. Motivational Interviewing (MI), a centred-person intervention aimed to empower and motivate the patient, could be a resource to improve…
- Trial name
- IMAGINE (NCT03434938)
- Testing
- Motivational interviewing
- Where
- 6 sites in Spain, Sweden
- Volunteers
- 272 people
- Sponsor
- Parc Sanitari Pere Virgili
Ischemic Stroke, Acute, Sleep Disorders, Circadian Rhythm
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
There is a lack of complex studies which could establish the association between genetic circadian factors with the features and short-term outcomes of ischemic stroke, as well as the effects of various auxiliary therapies for…
- Trial name
- NCT05247125
- Testing
- Blue light exposure + Melatonin treatment, Melatonin treatment, Blue light exposure
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Spinal Cord Injuries; Traumatic Brain Injury; Acquired Brain Injury, Stroke
TEleRehabilitation Nepal (TERN) to Improve Quality of Life of People With Spinal Cord Injury and Acquired Brain Injury
Nepal is a low-income country with over 3 million individuals with physical disabilities and currently no government-run specialist rehabilitation services.
- Trial name
- TERN (NCT04914650)
- Testing
- Telerehabilitation
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- University of Leeds
Syncope, Cryptogenic Stroke
BIO|STREAM.ICM France
The main objective of the BIO│STREAM.ICM France submodule is to provide clinical evidence from patients in France on safety and efficacy of the BIOMONITOR system
- Trial name
- NCT04206774
- Where
- 3 sites in France
- Volunteers
- 92 people
- Sponsor
- Biotronik SE & Co. KG
Stroke
Effects of Core Strengthening With Pelvic Proprioceptive Neuromuscular Facilitation on Trunk Control and Balance in Patients With Sub-acute Stroke
Purpose of this study was to investigate the effectiveness of core stabilization with pelvic proprioceptive neuromuscular facilitation on trunk control and balance which will be provided an evidence-based selection of the best…
- Trial name
- NCT07381491
- Testing
- Core stabilization exercises, PNF, Trunk control exercises
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Acute Stroke, Cerebral Ischemia
PMZ-1620 (Sovateltide) in Acute Ischemic Stroke Patients
This was a prospective, multicentric, randomized, double blind, parallel, saline controlled Phase II clinical study to compare the safety and efficacy of PMZ-1620 (INN: Sovateltide) therapy along with standard supportive care in…
- Trial name
- NCT04046484
- Testing
- Normal Saline along with standard treatment, PMZ-1620 along with standard treatment
- Where
- 7 sites in India
- Volunteers
- 40 people
- Sponsor
- Pharmazz, Inc.
Acute Basilar Artery Occlusion, Endovascular Therapy
The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction
This study assesses the efficacy and safety of endovascular therapy in patients with acute basilar artery occlusion with large core infarction within a multicenter, prospective, open-label, blinded endpoint, randomized controlled…
- Conditions
- Acute Basilar Artery Occlusion, Endovascular Therapy, Large Core Infarction
- Trial name
- NCT07333950
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
The Role of Peripheral Afferents in Modulating Post-stroke Central Pain
Central post-stroke pain (CPP) is extremely difficult to relieve and responds very poorly to analgesics targeting neuropathic pain, probably because the mechanisms underlying this pain remain poorly understood.
- Trial name
- APEDOC (NCT06446960)
- Testing
- Lidocaine 20mg/ml, Levobupivacaine Hydrochloride 1.25 MG/ML, Sodium Chloride 0.9% Inj
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hemiparesis as Late Effect of Cerebrovascular Disease
Role of Functional Translation After Immersive Virtual Reality Exposure in Persons With Stroke
This is a single-blinded randomized control trial aiming to explore the use of immersive virtual reality (VR) training in conjunction with real-life tasks therapy in 75 first time stroke patients with upper limb weakness.
- Trial name
- NCT04360460
- Testing
- Immersive virtual reality + related functional translation into real-life, Immersive virtual reality + non-related translation into real-life
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Loma Linda University
Stroke, Cognitive Decline
Efficacy and Safety of Immersive Virtual Reality for Post-stroke Cognitive Impairment
This is a single-blind randomized controlled trial to evaluate the efficacy and safety of immersive virtual reality for post-stroke cognitive impairment.
- Trial name
- EVRPSC (NCT06704360)
- Testing
- immersive VR pathfinding training, Occupational therapy
- Volunteers
- 40 people
- Sponsor
- Dingqun Bai
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