Clinical trials: Stromal Vascular Fraction
Crohn Disease
Evaluation of Local Co-administration of Autologous ADIpose Derived Stromal Vascular Fraction With Microfat for Refractory Perianal CROHN's Fistulas.
Autologous ADSVF constitutes an innovative therapeutic strategy that concentrates various types of regenerative stem cells and paracrine factors able to promote angiogenesis and tissue repair.
- Trial name
- ADICROHN2 (NCT04010526)
- Testing
- local co-administration of autologous ADIpose
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Arthritis, Degenerative
Use of Autologous Adipose-Derived Stromal Vascular Fraction to Treat Osteoarthritis of the Knee
Autologous adipose-derived stromal vascular fraction (SVF) was used to treat 10 osteoarthritic knees of grade II or III (K-L scale) under IRB-approved protocol in a feasibility and safety study.
- Trial name
- NCT02276833
- Testing
- intra-articular space injection of SVF
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Renew Center, San Antonio, Texas
Bladder Neck Obstruction, Bladder Outlet Obstruction
Effectiveness and Safety of Adipose-derived Regenerative Cells for Reduction of Risk of Bladder Neck Contracture
Autologous adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion from a portion of the fat harvested from the patient's front abdominal wall.
- Conditions
- Bladder Neck Obstruction, Bladder Outlet Obstruction, Benign Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
- Trial name
- NCT02869061
- Testing
- Liposuction, Transurethral bladder neck resection., ADRC
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Androgenic Alopecia
Autologous Stromal Vascular Fraction in Treatment of Male Androgenic Alopecia
Evaluation of Safety and efficacy of autologous stromal vascular fraction derived from denovo versus platelet rich plasma enhanced donner site in treatment of male androgenic alopecia
- Trial name
- NCT06326359
- Testing
- autologous stromal vascular fraction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Osteoarthritis
The Effects of Stromal Vascular Fraction and Mesenchymal Stem Cells as Intra-articular Injection in Knee Joint Osteoarthritis
Osteoarthritis of the knee is one of the most common causes of disability among elderly. As the disease progresses the cartilage become frustrated, surrounding bone react to become thicker and inflammation occurs in subchondral…
- Trial name
- NCT03164083
- Testing
- Mesenchymal stem cell
- Where
- Iran
- Sponsor
- SCARM Institute, Tabriz, Iran
Abnormally Healing Wounds, Scars
Safety of Adipose-Derived Stem Cell Stromal Vascular Fraction
A single-arm, open-labeled, single-center, descriptive and exploratory safety trial using ADSC-SVF-002. ADSC-SVF-002 is an autologous adipose derived stem cell (ADSC)-containing stromal vascular fraction (SVF) obtained from…
- Conditions
- Abnormally Healing Wounds, Scars, Soft Tissue Defects
- Trial name
- NCT02590042
- Testing
- ADSC-SVF-002
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AdiSave Inc.
Living-relative Kidney Transplantation
Induction With SVF Derived MSC in Living-related Kidney Transplantation
The objective of this trial is to determine if autologous SVF derived MSC can effectively reduce the need for post transplant immunosuppressant in living-relative kidney transplantation.
- Trial name
- NCT02492308
- Testing
- SVF-MSC induction, Basiliximab induction
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Fuzhou General Hospital
Multiple Sclerosis, Autoimmune
Use of Stromal Vascular Fraction in Multiple Sclerosis
Purpose of study is to determine safety and efficacy of use of autologous Adipose-Derived cellular Stromal Vascular Fraction (AD-cSVF) suspended in Normal Saline and delivered via intravascular system of quality of life and…
- Trial name
- GARM-MS (NCT03461419)
- Testing
- Microcannula Harvest Adipose Stroma, Centricyte 1000, Sterile Normal Saline IV Deployment of cSVF
- Where
- 2 sites in United States, Honduras
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Thumb Osteoarthritis
Autologous Stromal Vascular Fraction in the Treatment of Thumb Basal Joint Osteoarthritis
Trial purpose is to research the outcome after thumb carpometacarpal injection with stromal vascular fraction (SVF) derived from adipose tissue. The study compares SVF injection therapy with thumb splinting vs. splinting only.
- Trial name
- REMEDY SVF (NCT04455763)
- Testing
- SVF, Splint
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Töölö Hospital
Androgenetic Alopecia
Efficacy of Stromal Vascular Fraction Versus Platelet Rich Plasma in Treatment of Androgenitic Alopecia
The goal of this randomized controlled clinical trial is to test the efficacy \& safety of stromal vascular fraction in treatment of AGA \& compare it to PRP The main questions it aims to answer are: efficacy \& safety of SVF for…
- Trial name
- NCT06558565
- Testing
- stromal vascular fraction or platelet rich plasma
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kasr El Aini Hospital
Xerostomia Due to Radiotherapy (Disorder)
Stromal Vascular Fraction for Treatment of Xerostomia
Prospective, single center, double armed, randomized treatment with observation only (standard of care) control group. Subjects receiving study treatment will have 6 months of study follow-up.
- Trial name
- NCT03061110
- Testing
- Stromal Vascular Fraction, Usual Care
- Where
- United States
- Sponsor
- Midwestern Regional Medical Center
Vocal Fold Scars
Evaluating Autologous Stromal Vascular Fraction in Subjects with Vocal Fold Scar
The purpose of this research study is to assess if autologous Stromal Vascular Fraction (SVF) taken from the stomach or hips can help heal vocal fold scars.
- Trial name
- NCT05354544
- Testing
- Autologous adipose derived SVF
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Shane A. Shapiro
Penile Induration, Penile Diseases
Stem Cell Treatment of Peyronie´s Disease.
Purpose of the project is to investigate if a single injection of autologous stromal vascular fraction into and around plaque is a safe and suitable treatment.
- Trial name
- NCT04771442
- Testing
- Stromal vascular fraction
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Frail Elderly Syndrome, Aging
Autologous Stem/Stromal Cellular Stromal Vascular Fraction (cSVF) In Frailty-Aging Processes
With increasing age and health issues associated with aging, many systemic cellular and structural changes are known to occur. The intent of this trial is to determine the safety and efficacy of delivery of autologous cellular…
- Conditions
- Frail Elderly Syndrome, Aging, Degenerative Disease
- Trial name
- GARM-W (NCT03514537)
- Testing
- Microcannula harvest adipose stromal tissues, Centricyte 1000, Sterile Normal Saline IV Deployment of cSVF
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Healeon Medical Inc
Osteearthritis
Application of Autologous Stem Cells From Adipose Tissue in the Regeneration of Knee Joint Cartilage
This randomized, controlled clinical trial will evaluate the safety and effectiveness of autologous adipose-derived stromal vascular fraction (SVF) therapy in patients with knee osteoarthritis (OA) grades II-IV, compared with…
- Trial name
- NCT07405840
- Testing
- stromal vascular fraction (SVF), CP
- Where
- Serbia
- Volunteers
- 60 people
- Sponsor
- Clinical Center of Vojvodina
Obesity
Comparison Between Celution Preparation and Manual Preparation of Adipocyte Derived Regenerative Cells, Using Stromal Vascular Fraction Cell Counts (COMPARE)
This scientific study is meant to establish correlation in Stromal Vascular Fraction (SVF) cell counts between our manual method of harvesting and Cytori's Celution automated system.
- Trial name
- COMPARE (NCT01127230)
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Novena Medical Center
Ovarian Failure, Perimenopausal Disorder
Ovarian Rejuvenation Using Platelet Rich Plasma (PRP) & Autologous Tissue Stromal Vascular Fraction (tSVF) and Cell Enriched tSVF
Trial of imaging guided intra-ovarian injection to improve ovarian function in clinical settings of Premature Ovarian Failure, Perimenopausal and /or early postmenopausal symptomatology and related hormonal deficiencies.
- Conditions
- Ovarian Failure, Perimenopausal Disorder, Hormone Disturbance
- Trial name
- OVAR-REJUV (NCT04444245)
- Testing
- lipoaspiration harvest tSVF, Platelet Rich Plasma, Endovaginal Ultrasound
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Black Tie Medical, Inc.
Safety Issues
Safety Analysis of Implantation of Stromal Vascular Fraction
Stromal vascular fraction (SVF) can be isolated from fat (adipose) tissue in an outpatient in-clinic procedure. Platelet rich plasma (PRP) can be isolated from peripheral blood.
- Trial name
- NCT03226093
- Testing
- Stromal Vascular Fraction
- Volunteers
- 676 people
- Sponsor
- Bioheart, Inc.
Diabetic Foot, Diabetic Peripheral Neuropathy
Stromal Vascular Cells for the Treatment of Diabetic Peripheral Neuropathy
This is an interventional open-label study to determine the safety and clinical performance of SVF cells in the treatment of Diabetic Peripheral Neuropathy.
- Trial name
- SVFDPN (NCT07553468)
- Testing
- Adipose-derived Stromal Vascular Fraction Cells
- Where
- Nicaragua
- Volunteers
- 8 people
- Sponsor
- Michael H Carstens
Critical Limb Ischemia
Evaluation of the Tissue Genesis® Icellator Cell Isolation System™ to Treat Critical Limb Ischemia
The purpose of this study is to determine the safety and effectiveness of the Tissue Genesis® Icellator Cell Isolation System™ in Critical Limb Ischemia.
- Trial name
- CLI-DI (NCT02234778)
- Testing
- TGI SVF material via intramuscular injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tissue Genesis