Clinical trials: Structural Heart Diseases
Complication of Anesthesia, Ischaemia-reperfusion Injury
Dexmedetomidine Effect on Mitochondrial Function
The investigators hypothesize that in addition to a known sympatholytic effect, intraoperative dexmedetomidine reduces adverse changes in mitochondrial function and structure attenuating ischaemia-reperfusion and end-organ injury…
- Trial name
- NCT02299063
- Testing
- Dexmedetomidine, 0.9% NaCl
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- The Hospital for Sick Children
Hypertrophy, Left Ventricular
Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure
This study will assess the efficacy of mirabegron, a new beta3-adrenergic receptor in the prevention of heart failure. This is a two armed, prospective, randomized, placebo-controlled, multi-centric european phase IIb trial with…
- Trial name
- Beta3_LVH (NCT02599480)
- Testing
- mirabegron, Echocardiography, Cardiac MRI
- Where
- 10 sites in Belgium, France and 6 more
- Volunteers
- 296 people
- Sponsor
- Jean-Luc Balligand
Severe Aortic Valve Stenosis
VRAP-Heart - Virtual Reality Assisted Patient Empowerment for Interventions in Structural Heart Disease
This prospective, randomized-controlled multicenter study investigates whether virtual reality-assisted patient education in patients undergoing transfemoral transcatheter aortic valve implantation (TAVI) can improve patient…
- Trial name
- VRAP-Heart (NCT05552352)
- Testing
- Virtual Reality assisted information
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Hypertension
Irbesartan and Atenolol in Hypertensive Heart Disease
The renin-angiotensin-aldosterone system has been implicated in the control of structural changes of the heart and the vasculature, beyond the effects on blood pressure.
- Trial name
- SILVHIA (NCT00389168)
- Testing
- Irbesartan, Atenolol
- Where
- Sweden
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Paroxysmal Atrial Fibrillation
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease
The aim of this study is to study synergistic effect of eplerenone as Selective aldosterone receptor antagonist with amiodarone compared with amiodarone only in reducing recurrence of atrial fibrillation in patient with…
- Trial name
- NCT06168994
- Testing
- Eplerenone
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Failure, Chronic Kidney Diseases
Screen CardRen - A Cross-sectional Observational Cohort Study
In this single-centre, cross-sectional study, the investigators aim to assess the prevalence of asymptomatic echocardiographic structural and functional cardiac abnormalities in adult CKD patients with additional cardiovascular…
- Trial name
- NCT06272578
- Testing
- Echocardiography
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Charite University, Berlin, Germany
Essential Hypertension, Diabetes Mellitus
Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular
The anthypertensive treatment with Losartan may have benefits beyond blood pressure reduction on myocardial structure and function in hypertensive diabetic patients.
- Trial name
- NCT00659451
- Testing
- Losartan, Amlodipine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Pavia
Mitral Regurgitation
A Feasibility Registry of Actigraphy Monitoring in Degenerative Mitral Regurgitation Subjects Receiving the MitraClip® Device
A prospective, open-label, and multi-centered feasibility registry.
- Trial name
- VELOCITY (NCT02858245)
- Testing
- No intervention - registry
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Cardiovascular Diseases
NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial
The goal of this clinical trial is to determine if a machine learning/artificial intelligence (AI)-based electrocardiogram (ECG) algorithm (rECHOmmend and ECG-AF) can identify undiagnosed cardiovascular disease in patients.
- Conditions
- Atrial Fibrillation, Cardiovascular Diseases, Arrhythmia, Valvular Disease
- Trial name
- NOTABLE (NCT06511505)
- Testing
- Risk-Based Assessment for Cardiac Dysfunction
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cancer, Breast, Cardiotoxicity
Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2)
Although great progress has been made in treating breast cancer, long-term health may be impaired by cancer therapy. For example, some chemotherapy drugs (e.g., anthracyclines) are known to cause declines in heart health.
- Conditions
- Cancer, Breast, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- EXACT2 (NCT03748550)
- Testing
- Aerobic exercise
- Where
- 2 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Nova Scotia Health Authority
Anemia
(ACORD Study) - A Study of NeoRecormon (Epoetin Beta) in Patients With Early Diabetic Nephropathy
This study will assess the effect of anemia correction with NeoRecormon on cardiac structure and function in patients with early diabetic nephropathy.
- Trial name
- NCT00354341
- Testing
- Epoetin beta
- Where
- 63 sites in Austria, Brazil and 15 more
- Volunteers
- 170 people
- Sponsor
- Hoffmann-La Roche
Aortic Valve Disease, Artificial Heart Valves
Post-market Clinical Monitoring of the Safety and Efficacy of the Aortic Valve Bioprothesis
The goal of this multicenter prospective cohort study is to evaluate the long-term safety and efficacy of clinical outcomes of aortic valve replacement using the "TiAra" prosthesis with or without concomitant procedures.
- Trial name
- TiAra (NCT05998694)
- Where
- Russia
- Volunteers
- 2,000 people
- Sponsor
- Closed Joint-Stock Company NeoCor
Myocardial Ischemia
Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting
The success of coronary artery bypass grafting is reliant on the quality of the grafts used. A new technique for harvesting veins used as grafts has been introduced.
- Trial name
- IMPROVE-CABG (NCT01834846)
- Testing
- no-touch, conventional
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Congenital Heart Disease
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy
There are many kids born with congenital heart disease. Some of these defects may lead to the formation of a single ventricle (the heart having only one pumping chamber).
- Trial name
- NCT00165984
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Emory University
Cardiovascular Diseases, Heart Diseases
Vascular Disease--Structure/Function
To investigate the relationship of non-invasively measured flow-mediated brachial artery dilation with coronary artery disease (CAD).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005506
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation, Chronic Kidney Disease
The Effects of Renal Function and Atrial Fibrillation on Lipoproteins and Clot Structure/Function
This study is designed to investigate the role of lipids/lipoproteins as a potential cause for the harmful changes seen in fibrin clot properties with renal dysfunction and atrial fibrillation
- Trial name
- RALiC (NCT04043026)
- Testing
- Statin
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Liverpool