Clinical trials: Structure and Function of MRI
Type 2 Diabetes Mellitus, Cardiovascular Disease
Effects of Liraglutide in Young Adults With Type 2 DIAbetes (LYDIA)
There are recent advances in therapies for the treatment of Type 2 Diabetes Mellitus (T2DM) which include the GLP1 analogues and the DPP IV inhibitors.
- Trial name
- LYDIA (NCT02043054)
- Testing
- Liraglutide, Sitagliptin
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Leicester
Diffuse Diseases
Metabolic and Structural Characterization of Hub's Vulnerability in Neurological Diseases Assessed by Ultra High Field Structural and Functional MRI
the investigators hypothesize that hub alteration occurs both in diffuse diseases (MS, AD) as well as in more 'network specific' diseases (Parkinson, ALS, Epilepsy).
- Trial name
- NCT03039166
- Testing
- MRI 7T, MRI 3 T, blood sample
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Osteoarthritis
Effect of Glucosamine on Joint Structure and Quality of Life (JOG)
The goal of this study is 1) to develop a biomarker of of cartilage synthesis by determining if there is a relationship between changes in the status of knee cartilage and the amount of a biomarker called CTX-II in urine.
- Trial name
- NCT00377286
- Testing
- Glucosamine (a dietary supplement), 16 oz lite lemonade
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- University of Pittsburgh
Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment
Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative…
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment
- Trial name
- NCT07449117
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Patellar Tendinopathy / Jumpers Knee
Comparison of Ultrasound-guided Electrolysis Therapy vs. Sham Electrolysis in Patients With Patellar Tendinopathy: A Prospective Randomized Study Including MRI and Shear-wave Ultrasound Elastography Imaging
Study Background and Purpose Tendinopathies are common and debilitating musculoskeletal disorders that often lead to chronic pain and reduced mobility.
- Trial name
- NCT06939491
- Testing
- Ultrasound guided electrolysis therapy
- Where
- Germany
- Volunteers
- 74 people
- Sponsor
- Gymna Uniphy
Amyotrophic Lateral Sclerosis
Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II)
This study will try to understand the difference in brain structure between ALS patients and healthy people of similar age. ALS is a condition affecting the nervous system with disruption of the brain networks.
- Trial name
- CoALS-II (NCT05404867)
- Testing
- fMRI
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthy Diet, Healthy Aging
Acute Effects of Added Sugar Intake on Cerebrovascular Function and Brain Integrity
This study will focus on acute effects of added sugars on brain health in a specific age group (30-64 years old). We will provide participants two meals (one meal containing 16 g of added sugars and the other containing 61 g of…
- Trial name
- NCT05408338
- Testing
- Low Added Sugar Meal, High Added Sugar Meal
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Delaware
E Cigarette Use
Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with…
- Trial name
- NCT04616313
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFT)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder
Neurologic Injuries in Adults With Urea Cycle Disorders
Urea cycle disorders (UCDs) are a group of rare inherited metabolism disorders. The purpose of this study is to evaluate how UCD-related neurologic injuries affect adults with one of the most common types of UCD.
- Conditions
- Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency
- Trial name
- NCT00472732
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Andrea Gropman
Gastroesophageal Reflux Disease
Structure and Function of the Gastro-esophageal Junction
Aims of research project: To identify key features of the gastro-esophageal junction (structure and function) that protects the esophagus from gastro-esophageal reflux investigated by combined high resolution manometry and…
- Trial name
- NCT01053585
- Testing
- Baclofen
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Depression, Anxiety
Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders
In this study the investigators will seek to improve our understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of mood, substance use, and eating behavior.
- Conditions
- Depression, Anxiety, Eating Disorders, Drug Use Disorders
- Trial name
- NCT02450240
- Testing
- standardized diagnostic assessment, self-report questionnaires, behavioral tasks
- Where
- United States
- Volunteers
- 1,271 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Acromegaly
Cardiac (CMRI) Assessment of Acromegaly
In this study, the investigators will evaluate the cardiac structure and function, focusing on the myocardial water content and interstitial fibrosis, in patients with active acromegaly in comparison with 1) healthy volunteers…
- Trial name
- ACROCOEUR (NCT02948322)
- Testing
- CMRI, Gadolinium, OGTT
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognition, Affect (Mental Function)
ETASCAN Project: ETAS Project 2
This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.
- Conditions
- Cognition, Affect (Mental Function), Sleep, MRI
- Trial name
- ETASCAN (NCT07550140)
- Testing
- ETAS®
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Glioma, Glioma, Malignant
Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality of Life
Background Lower-grade-gliomas affect young patients, thus the longest progression-free-survival (PFS) with a high level quality of life is crucial.
- Trial name
- NCT06381726
- Testing
- Resting State Functional Magnetic Resonance Imaging (rs-fMRI), Up-front Motor Rehabilitation, Up-front Chemotherapy
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Milan
Parkinson Disease
Subthalamic Nucleus Connectivity in Parkinson's Disease With Ultra-high Field Magnetic Resonance Imaging
The purpose of this study is to investigate the segregation of the subthalamic nucleus into its motor and non-motor regions in patients with Parkinson's disease and healthy controls with the aid of ultra-high field magnetic…
- Trial name
- NCT01981577
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Covid19
Lung Structure-Function In Survivors of Mild and Severe COVID-19 Infection
This is a longitudinal study of the long-term impact of COVID-19 on the lungs. Participants will be followed over a period of up to 4 years and impacts of COVID-19 on the lungs will be measured with magnetic resonance imaging…
- Trial name
- LIVECOVIDFREE (NCT04584671)
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFT)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Healthy Subjects, Magnetic Resonance Imaging
Studying Motor Neuron Tests
Background: People with motor neuron disorders have changes in the parts of the brain that control movement. Some tests that are currently used to study these changes are magnetic resonance imaging (MRI) and transcranial magnetic…
- Conditions
- Healthy Subjects, Magnetic Resonance Imaging, Central Nervous System, Volunteer
- Trial name
- NCT01517087
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Irritable Bowel Syndrome, Cyclical Vomiting Syndrome
Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest.
The structural/RSN study involves Structural and Resting State Neuroimaging. The purpose of Structural Neuroimaging is to use MRI technology to identify cortical and white matter morphometric differences between patients with…
- Conditions
- Irritable Bowel Syndrome, Cyclical Vomiting Syndrome, Ulcerative Colitis, Vulvodynia
- Trial name
- MMI (NCT01517516)
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Acute Coronary Syndrome, Myocardial Infarction
Cardiac Structure, Function, and Clinical Manifestations in MINOCA
The purpose of this study is to improve the differential diagnosis and clinical outcomes of acute coronary syndrome with non-obstructive coronary arteries, to investigate the relationship between the structural and functional…
- Trial name
- MINOCA (NCT03572023)
- Testing
- Integrative characterization of MINOCA patients, Characterization of MI patients with coronary obstruction
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
COPD
Functional and Structural Assessment of Endobronchial Valve Recipients Using Dynamic Hyperpolarized Xenon-129 MRI
This study proposes to use hyperpolarized xenon-129 Magnetic Resonance Imaging (MRI) to study lung function of COPD patients who will receive endobronchial valve (EBV) therapy as part of their clinical standard-of-care.
- Trial name
- NCT05433961
- Testing
- MagniXene Hyperpolarized Xenon MRI
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Xemed LLC