Clinical trials: Sub-fertility
Endocrine Disease, Fertility Decreased Male
Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?
Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants.
- Conditions
- Endocrine Disease, Fertility Decreased Male, DNA Damage
- Trial name
- NCT03014882
- Testing
- L-Carnitine and N-acetyl cysteine
- Where
- 3 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infertility, Subfertility
Ovarian Response Prediction in In Vitro Fertilization (IVF) Patients
The aim of the study is to explore ovarian response in terms of oocyte numbers after ovarian stimulation in a fixed gonadotropin dose GnRH-antagonist protocol by endocrine (AMH, FSH), demographic (age), sonographic (antral…
- Trial name
- NCT01206803
- Testing
- Ovarian stimulation in a GnRH-antagonist protocol
- Where
- 5 sites in Germany, Norway
- Volunteers
- 294 people
- Sponsor
- University Hospital Schleswig-Holstein
Infertility, Sub-fertility
Human Papillomavirus and Rate of Pregnancy Achieved Via Medically Assisted Procreation
The main objective of this study is to investigate the association between the presence of HPV infection in one or both members of infertile/sub-infertile couples and the outcome of pregnancies obtained by assisted reproduction.
- Conditions
- Infertility, Sub-fertility, Papillomavirus Infections
- Trial name
- PAPILLO-PMA (NCT01894425)
- Where
- 4 sites in France
- Volunteers
- 700 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Subfertility, Anovulatory
The Effects of an Intensive Lifestyle Intervention on Reproductive Outcomes
This is a study to determine whether a low calorie diet using meal replacement shakes compared to current counseling about diet, followed by 3 cycles of clomiphene citrate (if needed) will result in: 1) improvements in ability to…
- Conditions
- Subfertility, Anovulatory, Obese
- Trial name
- NCT01894074
- Testing
- Intensive Dietary Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Amy E Rothberg
Subfertility
Is the IVF Outcome Dependent on the Time Interval Between hCG Administration and Oocyte Retrieval?
During controlled ovarian hyperstimulation (COH), human chorionic gonadotrophin (hCG) is administered to trigger the final follicular maturation before oocyte retrieval, in an attempt to mimic the physiologic effects of LH.
- Trial name
- NCT02044445
- Testing
- Oocyte retrieval will be performed 36 h or 38 h after hCG administration
- Where
- Greece
- Volunteers
- 154 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility, Reproductive Sterility
Post Market Surveillance & Post Market Clinical Follow up, International, Medical Registry to Confirm the Safety and the Performance of the Anecova Intra Uterine Culture Device
This study is designed to generate a comprehensive survey of the use on the market of the Anecova device within its intended indications according to the Instructions For Use.
- Trial name
- NCT03191890
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Anecova SA
Infertility
DNA Damage and Subfertility in Males - Impact on ART Outcome
A obvational prospective cohort study of men undergoing IUI, IVF and ICSI treatment in Denmark. The aim is to asses the impact of sperm DNA damage, measured as DNA fragmentation index (DFI), on reproductive outcomes after…
- Trial name
- ReproDNA (NCT04160208)
- Where
- Denmark
- Volunteers
- 1,350 people
- Sponsor
- Regionshospitalet Viborg, Skive
Polycystic Ovary Syndrome, Infertility
Inositol in Letrozol Resistant PCOS Women
Polycystic ovary syndrome (PCOS),is a complex neuro-endocrine disorder affecting approximately 5% to 10% of women in reproductive age.Inositols are considered insulin sensitizers, as they modulate the members of insulin signaling…
- Trial name
- NCT07585396
- Testing
- Myoinositol, Metformin
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Kafrelsheikh University
Polycystic Ovarian Syndrome, Subfertility
A Comparison of Letrozole and Clomifene Citrate
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies, affecting 5% to 10% of women of reproductive age. Women with PCOS suffer from anovulatory infertility.
- Trial name
- NCT02647424
- Testing
- Letrozole, Clomiphene
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Subfertility
Mild Versus Conventional Ovarian Stimulation Treatment for In Vitro Fertilization
In vitro fertilization (IVF) is an assisted reproductive technique to achieve pregnancy in subfertile couples of which the average success rate is only 25%.
- Trial name
- FOLFO (NCT00985062)
- Testing
- Mild Ovarian Stimulation Treatment, Conventional Ovarian Stimulation Treatment
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Erasmus Medical Center
Subfertility, Female
A Cross Sectional Evaluation of Vitamin D Status and Ovarian Reserve Markers
Evaluation of the association between vitamin D (VD) deficiency and ovarian reserve markers in a group of Pakistani sub fertile women was conducted
- Trial name
- NCT05137964
- Testing
- Vitamin D
- Volunteers
- 199 people
- Sponsor
- Australian Concept Medical Center
Subfertility
Effect of a Higher Than Maximum 450IU Gonadotropin Dose in an In-vitro Fertilization Cycle
This goal of this study is to evaluate the outcomes from in vitro fertilization cycles where a 450 IU daily dose of gonadotropins is administered compared to those where a 600 IU daily dose is administered for women who are at…
- Trial name
- NCT00971152
- Testing
- menotropins for injection, urofollitropin for injection
- Where
- Canada
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Clinique Ovo
Fertility Risk
Care Expansion Across Remote Environments - Sub-Study of the SELF-GYN1 Trial
This real-world, interventional sub-study will evaluate the impact of potential payer subsidies for Turtle Health at-home consults on subsequent interactions with the healthcare system within select sub-populations of interest.
- Trial name
- CARE (NCT05509322)
- Testing
- Subsidy for fertility consult, Invitation to purchase fertility consult
- Where
- United States
- Sponsor
- Turtle Health, Inc.
Subfertility
Comparative Effect of Theipoental and Propofol in IVF Outcome
In this study the aim is to compare the effect of the type of anaesthetic drug used during oocyte retrieval on fertilization rates of oocytes retrieved after ovarian stimulation for in-vitro fertilization.
- Trial name
- NCT02377778
- Testing
- Propofol, Thiopental
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- Aristotle University Of Thessaloniki
Sub-Fertility
Influence of FSH/LH Ratio in Controlled Ovarian Stimulation
The aim of this study is to compare different FSH/LH ratios in controlled ovarian stimulation
- Trial name
- NCT02994550
- Testing
- FSH/LH
- Volunteers
- 447 people
- Sponsor
- Hospital de Cruces
Infertility, Female
Immediate Ambulation Versus Short-time Bed Rest in Sub-fertile Women Undergoing Embryo Transfer
Bed rest after embryo transfer (ET) has been clinically advised without robust scientific evidence. In investigators' unit, post ET instructions are given immediately after ET to sub-fertile women while lying in bed.
- Trial name
- NCT05148624
- Testing
- embryo transfer
- Where
- United Arab Emirates
- Volunteers
- 156 people
- Sponsor
- Dubai Fertility Center
Subfertility
Comparison of the Number of Oocytes Obtained Between Chinese and Caucasian Women in IVF Treatment
IVF is a well-established method to treat various causes of infertility. Some studies have suggested that ethnicity affects the success of IVF.
- Trial name
- NCT02748278
- Testing
- Transvaginal ultrasound-guided oocyte retrieval, Embryo transfer
- Where
- China
- Volunteers
- 192 people
- Sponsor
- The University of Hong Kong
Subfertility
Predicting Ovarian Response in Artificial Insemination With Low Stimulation
This large prospective multi-center cohort study aims to identify patient's characteristics that significantly influence ovarian response to mild stimulation with a fixed dose of 75 IU recombinant FSH.
- Trial name
- NCT01662180
- Testing
- Follicle Stimulating Hormone
- Where
- 7 sites in Netherlands
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Isala
Subfertility
Dehydroepiandrosterone Versus Growth Hormone in Women Undergoing ICSI With Expected Poor Ovarian Response
300 women with expected poor ovarian response (POR) undergoing in vitro fertilization or intra-cytoplasmic sperm injection (ICSI) will be randomly divided into 2 equal groups using computer generated random numbers.
- Trial name
- NCT02736591
- Testing
- DHEA, Growth Hormone-Releasing Hormone
- Where
- 2 sites in Egypt
- Volunteers
- 210 people
- Sponsor
- Cairo University
Male Infertility, Male Subfertility
Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters
With declining fertility rates Worldwide, Assisted Reproductive Technology is seen as a viable solution for infertility, however, individual success rates following ART remain relatively low, rarely exceeding ~50%.
- Trial name
- PLCZeta (NCT07684339)
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Fakih IVF Fertility Center