Clinical trials: Subarachnoid Hemorrhage, Aneurysmal
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT07614906
- Where
- 2 sites in United States, Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Subarachnoid Hemorrhage
High-dose Simvastatin for Aneurysmal Subarachnoid Haemorrhage
Experimental evidences supported the benefit of Simvastatin in subarachnoid haemorrhage. Moreover, Simvastatin is a potent agent in achieving low-density lipoprotein (LDL) reduction with a proven safety profile.
- Trial name
- HDS-SAH (NCT01077206)
- Testing
- Simvastatin
- Where
- China
- Volunteers
- 255 people
- Sponsor
- Chinese University of Hong Kong
Aneurysmal Subarachnoid Hemorrhage
Multi-Center Registry Cohort Study on Prognostic Factors and Prediction Model Construction in Aneurysmal SAH
PROSAH-MPC, a collaborative research project among neurosurgical centers in China, focuses on aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- PROSAH-MPC (NCT05738083)
- Testing
- Machine Leaning Models
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Neuro-intensive Care Unit Patients, Subarachnoid Hemorrhage, Aneurysmal
Risk Factors and Outcomes in Patients Treated in Neurocritical Care
The overall purpose of this epidemiologic research project is to provide a comprehensive exploration and analysis of critical elements within the neuro-intensive care process in Sweden.
- Conditions
- Neuro-intensive Care Unit Patients, Subarachnoid Hemorrhage, Aneurysmal, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- EpiNIC (NCT07052656)
- Testing
- Observational study, participants are not assigned an intervention as part of the study., Transport modality
- Where
- Sweden
- Volunteers
- 70,000 people
- Sponsor
- Karolinska Institutet
Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:
Subarachnoid hemorrhage (SAH) occurs after rupture of cerebral aneurysms. Treatment of SAH focuses on avoiding medical complications including cerebral vasospasm, which may result in limited circulation to the brain.
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hyponatremia
- Trial name
- HS3 (NCT02432157)
- Testing
- HTS 3%, Standard fluid management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Aneurysmal Subarachnoid Hemorrhage
Effect of Antiplatelet Therapy on Cognition After Aneurysmal Subarachnoid Hemorrhage
Deficits in memory, executive function, and language are common cognitive sequelae of aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- NCT04548401
- Testing
- Antiplatelet Drug
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Aneurysmal Subarachnoid Hemorrhage
Fight INflammation to Improve Outcome After Aneurysmal Subarachnoid HEmorRhage
Aneurysmal subarachnoid hemorrhage (SAH) is a fatal disease with high morbidity and mortality. While the primary injury results from the initial bleeding and cannot be influenced, secondary injury through vasospasms and delayed…
- Trial name
- FINISHER (NCT05132920)
- Testing
- Dexamethasone
- Where
- 13 sites in Germany
- Volunteers
- 334 people
- Sponsor
- University Hospital, Bonn
Cerebral Ischemia, Subarachnoid Hemorrhage
Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage
The objective of this multi-centre, randomized controlled trial is to investigate the outcome after induced hypertension versus no induced hypertension in patients with delayed cerebral ischemia (DCI) after aneurysmal…
- Trial name
- HIMALAIA (NCT01613235)
- Testing
- Induced hypertension
- Where
- 2 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Aneurysmal Subarachnoid Hemorrhage
SpareBrain - Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage
Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about 1000 people in Finland suffer from SAH, their average age being under 50 years.
- Trial name
- NCT02026596
- Testing
- Magnetic resonance imaging, Cerebral microdialysis catheter insertion
- Where
- Finland
- Volunteers
- 61 people
- Sponsor
- Tampere University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm
Magnesium Treating Subarachnoid Hemorrhage Vasospasm
A randomized clinical trial investigating magnesium sulphate ability to reduce risk of cerebral vasospasm after acute subarachnoid hemorrhage hence improving outcome particularly in haptoglobin 2-2 patients who are highly…
- Trial name
- MATSH-SHapE (NCT04613960)
- Testing
- Magnesium sulfate, normal saline
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Cerebral Vasospasm
Safety Study of Nicardipine to Treat Cerebral Vasospasm
The purpose of this study is to determine if intrathecal nicardipine is safe for the treatment of cerebral vasospasm.
- Trial name
- NCT01810302
- Testing
- Nicardipine hydrochloride, Preservative-free normal saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Vasospasm
Safety Study of Cervical Sympathetic Block for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage
To evaluate the feasibility of performing a cervical sympathetic block in patients with severe cerebral vasospasm involving the anterior cerebral circulation following aneurysmal SAH.
- Trial name
- NCT00930072
- Testing
- Cervical Sympathetic Block (bupivicaine, clonidine)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Washington
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit
The goal of this observational study is to investigate DNA methylation changes in adults with bleeding from brain aneurysm, which is called aneurysmal subarachnoid hemorrhage (aSAH), and their association with delayed ischemic…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm After Subarachnoid Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT06881329
- Where
- Poland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Cognitive Dysfunction
Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage
This is a longitudinal, multi-center, prospective study of aneurysmal subarachnoid haemorrhage patients in neurosurgical units in Hong Kong.
- Trial name
- NCT01038193
- Testing
- Cognitive assessment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to test whether treatment with a drug called Simvastatin prevents and improves outcome in patients who have Subarachnoid bleeding.
- Trial name
- NCT00487461
- Testing
- Simvastatin 40 mg, Simvastatin 80 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Illinois Chicago
Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial
Chemical and Mechanical Angioplasty for Vasospasm (SAVEBRAIN)
This is a monocentric randomized prospective trial comparing 2 different endovascular strategies of intracranial arterial angioplasty in case of refractory intracranial arterial vasospastic stenosis : chemical angioplasty…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial, Stenosis, Ruptured Cerebral Aneurysm
- Trial name
- SAVEBRAIN (NCT05268445)
- Testing
- Chemical and Mechanical Angioplasty for Refractory Intracranial Arterial Vasospastic Stenosis
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Erasme University Hospital
Subarachnoid Hemorrhage of Aneurysmal Cause
Observational Study on Mortality and Outcome of Patients Hospitalized for Subarachnoid Hemorrhage of Aneurysmal Origin in Martinique Between 2013 and 2021
The aim of our study is to analyze mortality and sequelae of subarachnoid hemorrhage of aneurysmal origin in hospitalized patients in Martinique. Predictive factors of poor prognosis will also be analyzed.
- Trial name
- HSA Rankin (NCT06525012)
- Testing
- Usual patient care for patients hospitalized for subarachnoid hemorrhage of aneurysmal origin
- Where
- Martinique
- Volunteers
- 122 people
- Sponsor
- University Hospital Center of Martinique
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage
This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
- Trial name
- NCT07577739
- Testing
- Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury
Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage
An investigator-initiated clinical drug study Main Objective: To explore neuroprotective properties of xenon in patients after aneurysmal subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury, Cerebral Ischemia, Cerebral Infarction
- Trial name
- Xe-SAH (NCT04696523)
- Testing
- Xenon, air/oxygen
- Where
- 7 sites in Finland, Sweden
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital